Fragile X Syndrome FMR1 Detection by PCR Test sale cost 1500 AED
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Fragile X Syndrome FMR1 Detection by PCR Test Cost

Original price was: 2,000 د.إ.Current price is: 1,500 د.إ.

-25%

Fragile X Syndrome (FXS) is a genetic disorder that causes intellectual disability, behavioral challenges, and various physical characteristics. It is the most common form of inherited intellectual disability in males and a significant cause of intellectual disability in females. The disorder is linked to mutations in the FMR1 gene located on the X chromosome. These mutations lead to the production of an abnormal form of the protein needed for brain development.

The Polymerase Chain Reaction (PCR) test for Fragile X Syndrome is a specialized diagnostic tool used to detect the presence of mutations in the FMR1 gene. This test amplifies a small segment of the FMR1 gene’s DNA, allowing for the examination of its structure and the identification of any abnormalities that indicate Fragile X Syndrome. The PCR test is known for its high sensitivity and specificity in detecting various types of mutations, including the number of CGG repeats in the FMR1 gene, which is crucial for diagnosing Fragile X Syndrome.

In the United Arab Emirates, DNA Labs UAE offers this sophisticated testing service. The cost of the Fragile X Syndrome FMR1 detection by PCR test at DNA Labs UAE is 1500 AED. This facility is equipped with state-of-the-art technology and staffed by experienced professionals who ensure accurate and reliable test results. Opting for this test at DNA Labs UAE can provide families with crucial information regarding Fragile X Syndrome, facilitating early diagnosis and the opportunity for timely intervention and support.

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Fragile X Syndrome FMR1 Detection by PCR Test

Cost: 1500.0 AED

Symptoms and Diagnosis

Fragile X Syndrome (FXS) is a genetic disorder caused by a mutation in the FMR1 gene. This mutation leads to a reduced production of a protein called FMRP, which is crucial for normal brain development.

PCR (Polymerase Chain Reaction) is a technique used to amplify specific regions of DNA. In the case of Fragile X Syndrome, PCR can be used to detect the presence of the mutation in the FMR1 gene. The PCR-based method used for Fragile X Syndrome detection is called the Fragile X PCR test.

The Fragile X PCR test involves the following steps:

  1. DNA Extraction: DNA is extracted from a sample, usually blood or saliva, collected from the individual being tested.
  2. PCR Amplification: Specific primers are designed to target the region of the FMR1 gene that contains the mutation. The PCR reaction mixture is prepared, which includes the extracted DNA, the primers, and DNA polymerase enzyme. The reaction mixture is subjected to a series of temperature cycles that allow the DNA to denature, anneal with the primers, and then be amplified by the DNA polymerase enzyme.
  3. Gel Electrophoresis: After PCR amplification, the products are separated by gel electrophoresis. Gel electrophoresis is a technique that uses an electric field to separate DNA fragments based on their size. The gel is stained with a dye that binds to DNA, allowing the visualization of the amplified fragments.
  4. Analysis: The gel is examined under UV light, and the presence or absence of the Fragile X mutation is determined by comparing the size of the amplified fragments with known controls. Individuals with the mutation will show an abnormal pattern of DNA bands, indicating the presence of the mutation.

Test Details

The Fragile X PCR test is a reliable and widely used method for detecting Fragile X Syndrome. It allows for the identification of individuals with the mutation, enabling early diagnosis and appropriate management of the disorder.

Pre Test Information

Fragile X Syndrome (FMR1) detection by PCR can be done with a doctor’s prescription. However, the prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.

Test Department

Genetics

Doctor

General Physician

Sample Condition

Peripheral blood

Report Delivery

3-4 days

Components

EDTA Vacutainer (2ml)

Price

1500.0 AED

Test Name Fragile X Syndrome FMR1 detection by PCR Test
Components EDTA Vacutainer (2ml)
Price 1500.0 AED
Sample Condition Peripheral blood
Report Delivery 3-4 days
Method End Point PCR
Test type Genetics
Doctor General Physician
Test Department:
Pre Test Information Fragile X Syndrome (FMR1) detection by PCR can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

Fragile X Syndrome (FXS) is a genetic disorder caused by a mutation in the FMR1 gene. The mutation leads to a reduced production of a protein called FMRP, which is important for normal brain development.

PCR (Polymerase Chain Reaction) is a technique used to amplify specific regions of DNA. In the case of Fragile X Syndrome, PCR can be used to detect the presence of the mutation in the FMR1 gene.

The PCR-based method used for Fragile X Syndrome detection is called the Fragile X PCR test. It involves the following steps:

1. DNA Extraction: DNA is extracted from a sample, usually blood or saliva, collected from the individual being tested.

2. PCR Amplification: Specific primers are designed to target the region of the FMR1 gene that contains the mutation. These primers flank the mutation site. The PCR reaction mixture is prepared, which includes the extracted DNA, the primers, and DNA polymerase enzyme. The reaction mixture is subjected to a series of temperature cycles that allow the DNA to denature, anneal with the primers, and then be amplified by the DNA polymerase enzyme.

3. Gel Electrophoresis: After PCR amplification, the products are separated by gel electrophoresis. Gel electrophoresis is a technique that uses an electric field to separate DNA fragments based on their size. The gel is stained with a dye that binds to DNA, allowing the visualization of the amplified fragments.

4. Analysis: The gel is examined under UV light, and the presence or absence of the Fragile X mutation is determined by comparing the size of the amplified fragments with known controls. Individuals with the mutation will show an abnormal pattern of DNA bands, indicating the presence of the mutation.

PCR-based detection of Fragile X Syndrome is a reliable and widely used method. It allows for the identification of individuals with the mutation, enabling early diagnosis and appropriate management of the disorder.

SKU: TEST-5144 Category:

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