Test Price
2,800 AED✅ Home Collection Available
XIAP Gene Lymphoproliferative Syndrome, X-Linked Type 2, Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
This Next Generation Sequencing (NGS) test analyzes the XIAP gene for pathogenic mutations causing X-linked lymphoproliferative syndrome type 2 (XLP-2), a rare primary immunodeficiency disorder predisposing to hemophagocytic lymphohistiocytosis (HLH), hypogammaglobulinemia, and lymphoma. The assay delivers 99.9% diagnostic sensitivity across the full XIAP coding region and splice sites, enabling rapid clinical decision-making for hematologists, immunologists, and transplant physicians in the UAE.
- Turnaround Time: 3–4 Weeks from sample receipt to secure digital report distribution.
- Clinical Guidance: Complimentary 15-minute telephonic post-test guidance session with a Consultant Medical Geneticist.
- Insurance: Direct billing verification available via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The XIAP gene (X-linked Inhibitor of Apoptosis) encodes a protein critical for regulating immune cell survival and inflammatory signaling. Loss-of-function mutations in XIAP cause XLP-2, characterized by recurrent HLH episodes, splenomegaly, and increased lymphoma risk. This NGS-based test provides comprehensive variant detection across the entire XIAP coding region, intron-exon boundaries, and selected regulatory elements, with confirmation by Sanger sequencing for variants exceeding 10% allelic frequency.
| Feature | Our Test (NGS) | Closest Alternative (Conventional Sequencing) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity with full XIAP coding region coverage, including deep intronic variants | Lower sensitivity; misses deep intronic, regulatory, and mosaic variants |
| Methodology | NGS (Illumina platform) with ACMG variant classification, Sanger confirmation | Sanger sequencing; limited to one exon at a time |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Variant Classification | ACMG-AMP 2015 guidelines with ClinVar cross-referencing | Manual interpretation; limited database integration |
Physician Insight & Safety Protocols
“As a Consultant Medical Geneticist, I understand the anxiety that accompanies the possibility of an inherited immune disorder in a family. This NGS-based XIAP test provides definitive molecular clarity, but results must always be interpreted alongside a detailed three-generation pedigree, clinical phenotype, and immunological workup. Never adjust or discontinue a prescribed treatment regimen based solely on a genetic report without direct consultation with the managing specialist.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice: Medication Continuity
⚠ Do not discontinue or modify any prescribed immunosuppressive therapy, immunoglobulin replacement, or prophylactic antimicrobial regimen without explicit instruction from your hematologist or immunologist. Genetic testing results complement, not replace, clinical management decisions.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Pregnant women requiring urgent prenatal diagnosis must first undergo pre-test genetic counselling with a certified genetic counsellor. Post-test counselling for minors is mandatory per UAE Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Emergency Red Flag: Sudden onset of high fever (≥39°C), jaundice, hepatosplenomegaly, generalized lymphadenopathy, or neurological deterioration (seizures, altered consciousness) may indicate acute hemophagocytic lymphohistiocytosis (HLH). Seek immediate emergency department evaluation at the nearest tertiary care centre in Dubai or across the UAE.
Patient FAQ & Clinical Guidance
1. What is the XIAP gene test and who should consider it?
This molecular test identifies pathogenic mutations in the XIAP gene, confirming a diagnosis of X-linked lymphoproliferative syndrome type 2 (XLP-2). It is indicated for males presenting with recurrent or familial HLH, hypogammaglobulinemia, splenomegaly, or a maternal family history suggestive of XLP. Confirming the genetic diagnosis guides critical treatment decisions including hematopoietic stem cell transplantation (HSCT) and lifelong surveillance for lymphoma.
2. How is the test performed and what sample is required?
The test requires a peripheral whole blood sample (3–5 mL in EDTA tube), extracted genomic DNA, or a dried blood spot on an FTA card. A certified phlebotomist performs VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection from 8 AM to 11 PM daily, seven days a week. No fasting or medication adjustment is needed prior to collection. The sample is transported under ISO-certified cold chain conditions to our CAP-accredited laboratory for DNA extraction and NGS library preparation.
3. What will the results tell me and how will I receive them?
Results indicate one of three outcomes: (a) a pathogenic or likely pathogenic variant confirming XLP-2 diagnosis, (b) no pathogenic variant identified (negative result), or (c) a variant of uncertain significance (VUS) requiring further familial segregation analysis. A pathogenic result necessitates referral to a hematologist specializing in HSCT and immunoglobulin replacement therapy. You will receive a secure digital PDF report via encrypted email within 3–4 weeks, along with a complimentary 15-minute telephonic guidance session with our Consultant Medical Geneticist, Lina Osama Zaki Quteineh.
4. Does insurance cover this genetic test in the UAE?
Coverage varies by insurer and plan. Many Dubai Health Authority (DHA)-regulated and Abu Dhabi Department of Health (DoH)-regulated insurance policies provide partial or full coverage for genetic testing when ordered by a specialist and deemed medically necessary. Our team facilitates direct billing verification via WhatsApp at +971 54 548 8731. Please contact us before scheduling your test to confirm your specific policy benefits.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates in full compliance with the following UAE federal frameworks governing genetic data, patient privacy, and clinical laboratory practice:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic sequence data, clinical records, and personally identifiable information are encrypted at rest and in transit, with access restricted on a least-privilege basis.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Electronic health records and telemedicine platforms used for result delivery and post-test counselling comply with UAE health data interoperability and security standards.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Clinical safety protocols, pre-test informed consent, and post-test counselling procedures adhere to the medical liability framework, ensuring patient rights and professional accountability.
DNA Labs UAE is a DHA-licensed facility (License No. 1143) and maintains ISO 15189 accreditation for molecular genetic testing, with rigorous internal quality control and external proficiency testing programs.
Clinical & Logistical Metadata
| Test Name | XIAP Gene Sequencing (X-Linked Lymphoproliferative Syndrome Type 2) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA), extracted genomic DNA, or dried blood spot (FTA card). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next Generation Sequencing (NGS) on Illumina platform with Sanger confirmation; ACMG-AMP variant classification |
| ICD-10-CM Code | D82.3 |
| LOINC Code | 101373-6 |
| DHA Facility License & Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians