TPMT THIOPURINE METHYL TRANSFERASE GENOTYPING Test
At DNA Labs UAE, we offer the TPMT (thiopurine methyl transferase) genotyping test to determine an individual’s TPMT genotype. This genetic test is crucial in understanding how an individual metabolizes thiopurine drugs, such as azathioprine, mercaptopurine, and thioguanine.
Test Details
The TPMT genotyping test identifies specific genetic variations in the TPMT gene that can affect an individual’s ability to metabolize thiopurine drugs. By analyzing these genetic variations, healthcare providers can determine the appropriate dosage of thiopurine drugs for an individual.
Components and Price
The TPMT THIOPURINE METHYL TRANSFERASE GENOTYPING Test is priced at AED 1220.0. The test requires a sample condition of 4mL (2mL minimum) whole blood in 1 Lavender Top (EDTA) tube. It is important to ship the sample refrigerated and avoid freezing it. Additionally, a duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Report Delivery
The sample should be provided on Mondays or Thursdays by 11am, and the report will be delivered on Wednesdays or Saturdays.
Method
The TPMT genotyping test utilizes Real Time PCR as the method of analysis.
Test Type
The TPMT genotyping test falls under the category of Therapeutic Drug Monitoring.
Doctor and Test Department
This test is typically ordered by Oncologists and falls under the Molecular Diagnostics department.
Pre Test Information
A duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory before undergoing the TPMT genotyping test.
Understanding the TPMT Genotyping Test
Thiopurine drugs are commonly used to treat various medical conditions, including autoimmune diseases, inflammatory bowel disease, and certain types of cancer. The TPMT genotyping test helps identify specific genetic variations in the TPMT gene that can affect an individual’s ability to metabolize these drugs.
By analyzing an individual’s TPMT genotype, healthcare providers can determine the appropriate dosage of thiopurine drugs. This personalized approach ensures optimal therapeutic effect while minimizing the risk of adverse drug reactions.
The TPMT genotyping test involves collecting a sample of blood or saliva from the individual, which is then sent to our laboratory for analysis. Using techniques such as polymerase chain reaction (PCR) and DNA sequencing, we identify specific TPMT gene variants.
Individuals with TPMT gene variants associated with reduced enzyme activity may require lower doses of thiopurine drugs to avoid potential toxicity. On the other hand, individuals with TPMT gene variants associated with increased enzyme activity may require higher doses for optimal therapeutic effect.
Conclusion
The TPMT genotyping test is a valuable tool in personalized medicine. By understanding an individual’s genetic profile, healthcare providers can tailor drug therapy to maximize treatment outcomes and minimize the risk of adverse drug reactions.
At DNA Labs UAE, we are committed to providing accurate and reliable genetic testing services. Contact us today to learn more about the TPMT THIOPURINE METHYL TRANSFERASE GENOTYPING Test and how it can benefit you.
| Test Name | TPMT THIOPURINE METHYL TRANSFERASE GENOTYPING Test |
|---|---|
| Components | |
| Price | 1220.0 AED |
| Sample Condition | 4mL(2mLmin.)wholebloodin1 LavenderTop(EDTA)tube.Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
| Report Delivery | Sample Mon / Thu by 11am;Report Wed /Sat |
| Method | Real Time PCR |
| Test type | Therapeutic Drug Monitoring |
| Doctor | Oncologist |
| Test Department: | MOLECULAR DIAGNOSTICS |
| Pre Test Information | Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
| Test Details |
The TPMT (thiopurine methyl transferase) genotyping test is a genetic test that determines an individual’s TPMT genotype. TPMT is an enzyme that plays a crucial role in the metabolism of thiopurine drugs, such as azathioprine, mercaptopurine, and thioguanine. These drugs are commonly used to treat various medical conditions, including autoimmune diseases, inflammatory bowel disease, and certain types of cancer. The TPMT genotyping test identifies specific genetic variations in the TPMT gene that can affect an individual’s ability to metabolize thiopurine drugs. These genetic variations can lead to altered enzyme activity, resulting in either increased or decreased drug metabolism. This can have significant implications for drug efficacy and safety. The test involves collecting a sample of blood or saliva from the individual, which is then sent to a laboratory for analysis. The laboratory uses various techniques, such as polymerase chain reaction (PCR) and DNA sequencing, to identify specific TPMT gene variants. The results of the TPMT genotyping test can help healthcare providers determine the appropriate dosage of thiopurine drugs for an individual. Individuals with certain TPMT gene variants associated with reduced enzyme activity may require lower doses of these drugs to avoid potential toxicity. On the other hand, individuals with TPMT gene variants associated with increased enzyme activity may require higher doses for optimal therapeutic effect. Overall, the TPMT genotyping test is a valuable tool in personalized medicine, allowing healthcare providers to tailor drug therapy based on an individual’s genetic profile. This can help optimize treatment outcomes and minimize the risk of adverse drug reactions. |
