PROTEIN S FUNCTIONAL ACTIVITY Test – DNA Labs UAE

Are you concerned about your blood coagulation? At DNA Labs UAE, we offer the PROTEIN S FUNCTIONAL ACTIVITY Test to evaluate the functionality of protein S in regulating blood coagulation. Read on to learn more about this test, its cost, symptoms, diagnosis, and more.

Test Details

Protein S is a glycoprotein that plays a crucial role in the regulation of blood coagulation. Its main function is to enhance the activity of protein C, a natural anticoagulant. Protein S acts as a cofactor for protein C, assisting in inactivating clotting factors Va and VIIIa, which are involved in the coagulation cascade.

To test the functional activity of protein S, several laboratory tests can be performed:

1. Protein S Antigen Assay: This test measures the total amount of protein S in the blood. It determines the concentration of protein S and can help identify deficiencies or abnormalities in its production.
2. Protein S Activity Assay: This test evaluates the functional activity of protein S. It measures the ability of protein S to enhance the activity of protein C in inhibiting clotting factors Va and VIIIa.
3. Protein S Free Antigen Assay: Protein S circulates in two forms in the blood, free and bound to another protein called C4b-binding protein. This test measures the concentration of free protein S, which is the active form responsible for enhancing protein C activity.
4. Protein S Functional Assay: This test directly measures the ability of protein S to enhance protein C activity. It assesses the ability of protein S to inactivate clotting factors Va and VIIIa in a laboratory setting.

These tests are typically performed in combination to provide a comprehensive evaluation of protein S functionality and activity. They are useful in diagnosing protein S deficiency, which can lead to an increased risk of blood clotting disorders.

Test Cost

The cost of the PROTEIN S FUNCTIONAL ACTIVITY Test at DNA Labs UAE is AED 770.0.

Symptoms and Diagnosis

If you are experiencing symptoms related to blood coagulation disorders, such as unexplained blood clots or excessive bleeding, it is recommended to consult a hematologist for further evaluation. The hematologist may recommend the PROTEIN S FUNCTIONAL ACTIVITY Test to assess the functionality of protein S and determine if any deficiencies or abnormalities are present.

Sample Collection

To perform the PROTEIN S FUNCTIONAL ACTIVITY Test, a 3mL whole blood sample is required. The sample should be collected in a Blue Top (Sodium Citrate) tube and mixed thoroughly by inversion. It is important to transport the sample to the lab within 4 hours. If immediate transportation is not possible, the sample can be processed to obtain Platelet Poor Plasma (PPP) within 1 hour of collection. The PPP should be frozen immediately and shipped frozen to the lab without thawing.

Pre-Test Information

It is recommended to fast overnight before undergoing the PROTEIN S FUNCTIONAL ACTIVITY Test. Patients should discontinue Heparin for 1 day and Oral Anticoagulants for 7 days prior to sampling, as these drugs may affect the test results. However, discontinuation of these medications should be done with prior consent from the treating physician. Additionally, a duly filled Coagulation Requisition Form (Form 15) is mandatory for the test.

Report Delivery

The sample should be submitted to the lab by Thursday 9 am. The report will be delivered on the next day.

Conclusion

At DNA Labs UAE, we understand the importance of evaluating the functionality of protein S in blood coagulation. Our PROTEIN S FUNCTIONAL ACTIVITY Test provides a comprehensive assessment of protein S activity, helping diagnose deficiencies and abnormalities. If you are experiencing symptoms related to blood clotting disorders, consult a hematologist and consider undergoing this test for a thorough evaluation. Contact DNA Labs UAE today to schedule your PROTEIN S FUNCTIONAL ACTIVITY Test.