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PNH Comprehensive Work-Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GLY-A Test Cost

Original price was: 3,200 د.إ.Current price is: 2,400 د.إ.

-25%

The “PNH Comprehensive Work-Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GLY-A Test” is an advanced diagnostic assessment offered by DNA Labs UAE, designed to identify and evaluate Paroxysmal Nocturnal Hemoglobinuria (PNH), a rare and life-threatening blood disorder. This test employs flow cytometry technology combined with specific markers—FLAER (Fluorescent Aerolysin), CD14, CD15, CD24, CD45, CD59, CD64, and Glycosylphosphatidylinositol (GPI) anchor (GLY-A)—to detect the absence or reduction of GPI-anchored proteins on the surface of blood cells, which is characteristic of PNH.

The inclusion of FLAER and a comprehensive panel of markers enhances the sensitivity and specificity of the test, allowing for a detailed analysis of different cell populations, including red blood cells, white blood cells, and platelets. This thorough approach aids in the accurate diagnosis of PNH, facilitating appropriate treatment planning and management for affected individuals.

The test is priced at 2400 AED and is performed in the state-of-the-art facilities of DNA Labs UAE, ensuring high-quality diagnostic services. By leveraging advanced flow cytometry techniques and expert analysis, DNA Labs UAE provides critical insights into PNH, supporting healthcare providers in delivering targeted care to patients with this complex condition.

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PNH Comprehensive Work Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GlY-A Test

At DNA Labs UAE, we offer the PNH Comprehensive Work Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GlY-A Test. This test is an important diagnostic tool for identifying and monitoring paroxysmal nocturnal hemoglobinuria (PNH), a rare acquired hematopoietic stem cell disorder.

Test Components

The PNH Comprehensive Work Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GlY-A Test includes:

  • EDTA Vacutainer (2ml) or Sodium heparin Vacutainer (2ml)

Price

The cost of the PNH Comprehensive Work Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GlY-A Test is 2400.0 AED.

Sample Condition

The test requires a peripheral blood sample.

Report Delivery

You can expect to receive your test report within 1-2 days.

Method

The PNH Comprehensive Work Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GlY-A Test is conducted using flow cytometry, a widely used technique for diagnosing PNH.

Test Type

The PNH Comprehensive Work Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GlY-A Test falls under the category of genetics tests.

Doctor

The test can be ordered by a General Surgeon.

Pre Test Information

It is important to note that the PNH Comprehensive Work Up(Flowcytometry)-Flaer, CD14, CD15, CD24, CD45, CD59, CD64, GlY-A Test requires a doctor’s prescription. However, prescriptions are not applicable for surgery and pregnancy cases, as well as individuals planning to travel abroad.

Test Details

PNH (paroxysmal nocturnal hemoglobinuria) is a rare acquired hematopoietic stem cell disorder characterized by the abnormal expansion of a clone of cells that lack certain proteins on their surface. This results in the destruction of red blood cells (hemolysis), leading to symptoms such as hemoglobinuria (dark urine), anemia, fatigue, and thrombosis.

Flow cytometry is a technique commonly used to diagnose PNH and assess the size of the PNH clone. It involves the use of fluorescently-labeled antibodies that bind to specific cell surface markers. By analyzing the fluorescence pattern of individual cells, flow cytometry can identify abnormal populations of cells in the blood.

The comprehensive work-up for PNH using flow cytometry typically includes the following markers:

  1. FLAER (fluorescent aerolysin): FLAER is a toxin derived from the bacteria Aeromonas hydrophila that specifically binds to glycosylphosphatidylinositol (GPI) anchors. In PNH, the absence of GPI-anchored proteins on the cell surface can be detected using FLAER, which binds to the residual GPI anchors on PNH cells.
  2. CD14: CD14 is a marker expressed on monocytes and macrophages. In PNH, the absence of CD14 on the cell surface can indicate the presence of PNH clones.
  3. CD15: CD15 is a marker expressed on neutrophils and some monocytes. The absence of CD15 on the cell surface can be indicative of PNH clones.
  4. CD24: CD24 is a marker expressed on lymphocytes, monocytes, and granulocytes. The absence of CD24 on the cell surface can suggest the presence of PNH clones.
  5. CD45: CD45 is a marker expressed on all nucleated hematopoietic cells. PNH clones often have decreased expression of CD45, which can be detected using flow cytometry.
  6. CD59: CD59 is a GPI-anchored protein that inhibits the formation of the membrane attack complex (MAC), which is responsible for the destruction of red blood cells. The absence of CD59 on the cell surface is a hallmark of PNH.
  7. CD64: CD64 is a marker expressed on monocytes and macrophages. Its absence on the cell surface can indicate the presence of PNH clones.
  8. Gly-A: Gly-A is a marker expressed on red blood cells. The absence of Gly-A on the cell surface can suggest the presence of PNH clones.

By analyzing the expression levels of these markers on different cell populations, flow cytometry can provide valuable information about the presence and size of PNH clones. This information is crucial for diagnosing PNH and monitoring disease progression.

Test Name PNH Comprehensive Work Up Flowcytometry-Flaer CD14 CD15 CD24 CD45CD59 CD64 GlY-A Test
Components EDTA Vacutainer (2ml)/Sodium heparin Vacutainer (2ml)
Price 2400.0 AED
Sample Condition Peripheral blood
Report Delivery 1-2 days
Method Flowcytometry
Test type Genetics
Doctor General Surgeon
Test Department:
Pre Test Information PNH Comprehensive Work Up(Flowcytometry)-Flaer, CD14, CD15, CD24, CD45,CD59, CD64, GlY-A can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

PNH (paroxysmal nocturnal hemoglobinuria) is a rare acquired hematopoietic stem cell disorder characterized by the abnormal expansion of a clone of cells that lack certain proteins on their surface. This results in the destruction of red blood cells (hemolysis), leading to symptoms such as hemoglobinuria (dark urine), anemia, fatigue, and thrombosis.

Flow cytometry is a technique commonly used to diagnose PNH and assess the size of the PNH clone. It involves the use of fluorescently-labeled antibodies that bind to specific cell surface markers. By analyzing the fluorescence pattern of individual cells, flow cytometry can identify abnormal populations of cells in the blood.

The comprehensive work-up for PNH using flow cytometry typically includes the following markers:

1. FLAER (fluorescent aerolysin): FLAER is a toxin derived from the bacteria Aeromonas hydrophila that specifically binds to glycosylphosphatidylinositol (GPI) anchors. In PNH, the absence of GPI-anchored proteins on the cell surface can be detected using FLAER, which binds to the residual GPI anchors on PNH cells.

2. CD14: CD14 is a marker expressed on monocytes and macrophages. In PNH, the absence of CD14 on the cell surface can indicate the presence of PNH clones.

3. CD15: CD15 is a marker expressed on neutrophils and some monocytes. The absence of CD15 on the cell surface can be indicative of PNH clones.

4. CD24: CD24 is a marker expressed on lymphocytes, monocytes, and granulocytes. The absence of CD24 on the cell surface can suggest the presence of PNH clones.

5. CD45: CD45 is a marker expressed on all nucleated hematopoietic cells. PNH clones often have decreased expression of CD45, which can be detected using flow cytometry.

6. CD59: CD59 is a GPI-anchored protein that inhibits the formation of the membrane attack complex (MAC), which is responsible for the destruction of red blood cells. The absence of CD59 on the cell surface is a hallmark of PNH.

7. CD64: CD64 is a marker expressed on monocytes and macrophages. Its absence on the cell surface can indicate the presence of PNH clones.

8. Gly-A: Gly-A is a marker expressed on red blood cells. The absence of Gly-A on the cell surface can suggest the presence of PNH clones.

By analyzing the expression levels of these markers on different cell populations, flow cytometry can provide valuable information about the presence and size of PNH clones. This information is crucial for diagnosing PNH and monitoring disease progression.

SKU: TEST-4806 Category:

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