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PML RARA t1517q22q12 Gene Rearrangement Quantitative PCR Test Cost

Original price was: 1,350 د.إ.Current price is: 1,220 د.إ.

-10%

The PML RARA t(15;17)(q22;q12) Gene Rearrangement Quantitative PCR Test is a sophisticated diagnostic assay performed at DNA Labs UAE, designed to detect the specific chromosomal abnormality t(15;17)(q22;q12). This rearrangement results in the fusion of the PML gene on chromosome 15 with the RARA gene on chromosome 17, a hallmark of Acute Promyelocytic Leukemia (APL), a subtype of acute myeloid leukemia. The test employs quantitative Polymerase Chain Reaction (PCR) techniques to precisely measure the levels of the PML-RARA fusion gene, which is critical for diagnosing APL, monitoring treatment response, and detecting minimal residual disease (MRD) in patients.

With a cost of 1220 AED, the test is an essential tool in the personalized management of patients with APL, offering rapid and sensitive detection of the PML-RARA rearrangement. This information is invaluable for clinicians in guiding treatment decisions, including the use of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), which specifically target cells expressing the PML-RARA fusion protein. By quantifying the presence of the fusion gene, the test not only confirms the diagnosis but also helps in predicting patient prognosis and in the early detection of relapse, making it a cornerstone in the management of Acute Promyelocytic Leukemia.

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PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test

At DNA Labs UAE, we offer the PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test for the diagnosis and management of acute promyelocytic leukemia (APL). This test detects the presence and quantifies the level of a specific gene rearrangement called PML-RARA.

Test Details

The PML-RARA t(15;17)(q22;q12) gene rearrangement quantitative PCR (polymerase chain reaction) test is a diagnostic test used to detect the presence and quantify the level of a specific gene rearrangement called PML-RARA. This rearrangement is characteristic of a specific type of leukemia called acute promyelocytic leukemia (APL). APL is a subtype of acute myeloid leukemia (AML) that is characterized by the fusion of two genes: the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor alpha (RARA) gene on chromosome 17. This fusion gene, PML-RARA, plays a crucial role in the development of APL.

The quantitative PCR test is performed on a blood or bone marrow sample from a patient suspected to have APL. It measures the amount of PML-RARA fusion gene in the sample, which can provide information about the disease burden and response to treatment. The test is highly sensitive and can detect even very low levels of PML-RARA. The results of the quantitative PCR test are reported as a numerical value, indicating the level of PML-RARA gene expression.

Test Cost

The cost of the PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test is 1220.0 AED.

Symptoms and Diagnosis

Common symptoms of APL include fatigue, shortness of breath, frequent infections, bleeding, and bruising. If you are experiencing these symptoms or if your doctor suspects APL based on your medical history and physical examination, they may recommend the PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test to confirm the diagnosis.

Referring Details

To perform the test, we require a 5 mL (3 mL min.) whole blood sample from 2 Lavender Top (EDTA) tubes. The sample should be shipped refrigerated and should not be frozen. Additionally, a duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.

Report Delivery

The sample for the PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test should be submitted on Monday, Wednesday, or Friday by 9 am. The test report will be delivered on Tuesday, Thursday, or Saturday.

Test Type

The PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test falls under the category of Leukemia tests.

Doctor and Test Department

This test is typically ordered by an Oncologist and is performed in our Molecular Diagnostics department.

Pre Test Information

A duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory before performing the PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test.

Conclusion

The PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test is an important tool in the diagnosis, monitoring, and management of APL patients. It provides valuable information about the disease status and guides treatment decisions. If you suspect APL or have been diagnosed with APL, consult with your doctor about the possibility of undergoing this test.

Test Name PML RARA t1517q22q12 GENE REARRANGEMENT QUANTITATIVE PCR Test
Components
Price 1220.0 AED
Sample Condition 5 mL (3 mL min.)wholebloodfrom2 LavenderTop(EDTA)tubes. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Report Delivery SampleMon/Wed / Fri by 9 am;Report Tue / Thu / Sat
Method Real Time PCR
Test type Leukemia
Doctor Oncologist
Test Department: MOLECULAR DIAGNOSTICS
Pre Test Information Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Test Details

The PML-RARA t(15;17)(q22;q12) gene rearrangement quantitative PCR (polymerase chain reaction) test is a diagnostic test used to detect the presence and quantify the level of a specific gene rearrangement called PML-RARA. This rearrangement is characteristic of a specific type of leukemia called acute promyelocytic leukemia (APL).

APL is a subtype of acute myeloid leukemia (AML) that is characterized by the fusion of two genes: the promyelocytic leukemia (PML) gene on chromosome 15 and the retinoic acid receptor alpha (RARA) gene on chromosome 17. This fusion gene, PML-RARA, plays a crucial role in the development of APL.

The quantitative PCR test is performed on a blood or bone marrow sample from a patient suspected to have APL. It measures the amount of PML-RARA fusion gene in the sample, which can provide information about the disease burden and response to treatment. The test is highly sensitive and can detect even very low levels of PML-RARA.

The results of the quantitative PCR test are reported as a numerical value, indicating the level of PML-RARA gene expression. Monitoring the levels of PML-RARA during and after treatment can help assess the effectiveness of therapy and detect any relapse or residual disease.

This test is an important tool in the diagnosis, monitoring, and management of APL patients, as it provides valuable information about the disease status and guides treatment decisions.

SKU: TEST-5641 Category:

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