PML RARA t1517q22q12 GENE REARRANGEMENT QUALITATIVE PCR Test
Test Cost: AED 1220.0
Symptoms, Diagnosis, and Test Details
The PML-RARA t(15;17)(q22;q12) gene rearrangement qualitative PCR test is a diagnostic test used to detect the presence of a specific genetic rearrangement in the PML and RARA genes. This rearrangement is commonly found in patients with acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML).
The test involves using PCR (polymerase chain reaction) technology to amplify and detect the specific DNA sequence associated with the PML-RARA gene rearrangement. The qualitative aspect of the test indicates whether the rearrangement is present or not, rather than providing quantitative information about the level of rearrangement.
The test is typically performed on a bone marrow or blood sample from the patient. If the PML-RARA gene rearrangement is detected, it confirms the diagnosis of APL and can help guide treatment decisions, as APL often requires specific targeted therapy with drugs such as all-trans retinoic acid (ATRA) or arsenic trioxide.
It is important to note that the PML-RARA gene rearrangement is specific to APL and is not found in other types of leukemia or normal cells. Therefore, this test is highly specific for the diagnosis of APL and can help differentiate it from other types of leukemia.
Test Components and Price
Components: PML RARA t1517q22q12 GENE REARRANGEMENT QUALITATIVE PCR Test
Price: 1220.0 AED
Sample Condition and Report Delivery
Sample Condition: 5 mL (3 mL min.) whole blood from 2 Lavender Top (EDTA) tubes. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Report Delivery: Sample Mon/Wed/Fri by 9am; Report Tue/Thu/Sat
Method and Test Type
Method: Real Time PCR
Test Type: Leukemia
Referring Doctor and Test Department
Doctor: Oncologist
Test Department: MOLECULAR DIAGNOSTICS
Pre Test Information
Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
| Test Name | PML RARA t1517q22q12 GENE REARRANGEMENT QUALITATIVE PCR Test |
|---|---|
| Components | |
| Price | 1220.0 AED |
| Sample Condition | 5 mL (3 mL min.)wholebloodfrom2 LavenderTop(EDTA)tubes.Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
| Report Delivery | SampleMon/Wed / Fri by 9am;Report Tue / Thu / Sat |
| Method | Real Time PCR |
| Test type | Leukemia |
| Doctor | Oncologist |
| Test Department: | MOLECULAR DIAGNOSTICS |
| Pre Test Information | Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
| Test Details |
The PML-RARA t(15;17)(q22;q12) gene rearrangement qualitative PCR test is a diagnostic test used to detect the presence of a specific genetic rearrangement in the PML and RARA genes. This rearrangement is commonly found in patients with acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML). The test involves using PCR (polymerase chain reaction) technology to amplify and detect the specific DNA sequence associated with the PML-RARA gene rearrangement. The qualitative aspect of the test indicates whether the rearrangement is present or not, rather than providing quantitative information about the level of rearrangement. The test is typically performed on a bone marrow or blood sample from the patient. If the PML-RARA gene rearrangement is detected, it confirms the diagnosis of APL and can help guide treatment decisions, as APL often requires specific targeted therapy with drugs such as all-trans retinoic acid (ATRA) or arsenic trioxide. It is important to note that the PML-RARA gene rearrangement is specific to APL and is not found in other types of leukemia or normal cells. Therefore, this test is highly specific for the diagnosis of APL and can help differentiate it from other types of leukemia. |
