PICALM Gene Immunological Disorder
At DNA Labs UAE, we offer the PICALM Gene Immunological Disorder genetic test for individuals who suspect they may have an immunological disorder related to the PICALM gene. This test can help in the diagnosis and risk assessment of various immunological disorders.
Test Details
The PICALM (Phosphatidylinositol binding clathrin assembly protein) gene is responsible for the formation of clathrin-coated vesicles, which are crucial for endocytosis and intracellular trafficking. Mutations in the PICALM gene have been associated with several immunological disorders.
One example of an immunological disorder related to the PICALM gene is Alzheimer’s disease. Studies have shown that PICALM gene variants increase the risk of developing Alzheimer’s disease. These variants can affect the normal function of clathrin-mediated endocytosis, leading to impaired clearance of amyloid-beta plaques, a hallmark of Alzheimer’s disease.
Additionally, PICALM gene variants have also been associated with autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. These variants may contribute to dysregulation of immune responses and abnormal antigen presentation, leading to the development of autoimmune disorders.
To identify mutations or variants in the PICALM gene, we utilize Next-Generation Sequencing (NGS) technology. NGS genetic testing allows for the simultaneous analysis of multiple genes, providing a comprehensive assessment of an individual’s genetic makeup.
Test Components and Price
The PICALM Gene Immunological Disorder genetic test is priced at 4400.0 AED. The test requires a blood sample, extracted DNA, or one drop of blood on an FTA card. The report delivery time is approximately 3 to 4 weeks.
Doctor and Test Department
The PICALM Gene Immunological Disorder genetic test is conducted under the supervision of a dermatologist. The test falls under the Genetics department at DNA Labs UAE.
Pre-Test Information
Prior to undergoing the PICALM Gene Immunological Disorder genetic test, it is important to provide the clinical history of the patient. A genetic counseling session will be conducted to draw a pedigree chart of family members affected by the PICALM Gene Immunological Disorder. This will help in assessing the inheritance pattern and risk assessment.
Interpreting Test Results
It is crucial to note that while PICALM gene variants may increase the risk of developing certain immunological disorders, they do not guarantee the development of the disease. Genetic testing results should be interpreted in conjunction with clinical symptoms and other relevant factors to provide a comprehensive assessment of an individual’s health.
At DNA Labs UAE, we strive to provide accurate and reliable genetic testing services. Our PICALM Gene Immunological Disorder genetic test can help individuals gain insights into their genetic makeup and potential risk for immunological disorders associated with PICALM gene mutations.
| Test Name | PICALM Gene Immunological disorder PICALM related Genetic Test |
|---|---|
| Components | |
| Price | 4400.0 AED |
| Sample Condition | Blood or Extracted DNA or One drop Blood on FTA Card |
| Report Delivery | 3 to 4 Weeks |
| Method | NGS Technology |
| Test type | Osteology Dermatology Immunology Disorders |
| Doctor | Dermatologist |
| Test Department: | Genetics |
| Pre Test Information | Clinical History of Patient who is going for PICALM Gene Immunological disorder, PICALM related NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with PICALM Gene Immunological disorder, PICALM related NGS Genetic DNA Test gene PICALM |
| Test Details |
The PICALM (Phosphatidylinositol binding clathrin assembly protein) gene is involved in the formation of clathrin-coated vesicles, which play a crucial role in endocytosis and intracellular trafficking. Mutations in the PICALM gene have been associated with various immunological disorders. One example of an immunological disorder related to the PICALM gene is Alzheimer’s disease. Studies have shown that PICALM gene variants are associated with an increased risk of developing Alzheimer’s disease. These variants may affect the normal function of clathrin-mediated endocytosis, leading to impaired clearance of amyloid-beta plaques, a hallmark of Alzheimer’s disease. Another example is the association between PICALM gene variants and susceptibility to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. These variants may contribute to dysregulation of immune responses and abnormal antigen presentation, leading to the development of autoimmune disorders. NGS (Next-Generation Sequencing) genetic testing can be used to identify mutations or variants in the PICALM gene. This type of genetic testing allows for the simultaneous analysis of multiple genes, providing a comprehensive assessment of an individual’s genetic makeup. By identifying PICALM gene variants, NGS genetic testing can help in the diagnosis and risk assessment of immunological disorders associated with PICALM gene mutations. It’s important to note that while PICALM gene variants may increase the risk of developing certain immunological disorders, they do not guarantee the development of the disease. Genetic testing results should be interpreted in conjunction with clinical symptoms and other relevant factors to provide a comprehensive assessment of an individual’s health. |
