Nx Gen Sequencing Alexander Disease Test sale cost 4680 AED
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Nx Gen Sequencing Alexander Disease Test Cost

Original price was: 5,200 د.إ.Current price is: 4,680 د.إ.

-10%

The “Nx Gen Sequencing Alexander Disease Test” is a sophisticated genetic test offered by DNA Labs UAE, designed to diagnose Alexander Disease, a rare neurological disorder. This state-of-the-art testing method employs Next Generation Sequencing (NGS) technology to accurately identify mutations in the GFAP gene, which are responsible for causing this condition. Alexander Disease is characterized by the destruction of white matter in the brain and a progressive decline in motor skills and intellectual function. Early and accurate diagnosis through the Nx Gen Sequencing Test can be crucial for managing symptoms and planning appropriate treatments. The test is priced at 4680 AED, reflecting the advanced technology and expertise required to conduct this specialized genetic analysis. DNA Labs UAE provides this service, ensuring high-quality testing and reliable results for patients and healthcare providers seeking insights into this rare genetic disorder.

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Nx GEN SEQUENCING ALEXANDER DISEASE Test

Welcome to DNA Labs UAE, a leading genetic lab offering advanced testing services. In this blog, we will discuss the Nx GEN SEQUENCING ALEXANDER DISEASE Test, including its cost, symptoms, diagnosis process, and more.

Test Details

Alexander Disease is a rare genetic disorder that affects the nervous system. It is caused by mutations in the GFAP gene, which encodes the glial fibrillary acidic protein. This protein is essential for the normal functioning of astrocytes, a type of brain cell.

To test for Alexander Disease, a next-generation sequencing (NGS) approach can be used. NGS allows for the simultaneous sequencing of multiple genes, making it a powerful tool for genetic testing.

Here is a general overview of the steps involved in the NGS testing process for Alexander Disease:

  1. Sample collection: A small sample of DNA is collected from the patient, typically through a blood sample or a cheek swab.
  2. DNA extraction: The DNA is extracted from the collected sample using standard laboratory techniques.
  3. Library preparation: The extracted DNA is then fragmented and prepared for sequencing. This involves attaching specific DNA adapters to the fragments, which will allow for the amplification and sequencing of the target genes.
  4. Targeted sequencing: The prepared DNA library is loaded onto a sequencing instrument, such as an Illumina sequencer. The instrument will sequence the DNA fragments and generate millions of short reads.
  5. Data analysis: The generated sequencing data is then analyzed using bioinformatics tools. This involves aligning the reads to a reference genome and identifying any genetic variations or mutations in the GFAP gene.
  6. Variant interpretation: The identified genetic variations are then compared to known disease-causing mutations in the GFAP gene. Clinicians and geneticists will assess the significance of these variants and determine whether they are likely to be causing Alexander Disease.

It’s important to note that NGS testing can also include other genes associated with similar neurological disorders to rule out other potential causes of symptoms. Additionally, genetic testing for Alexander Disease can also be done using other techniques, such as Sanger sequencing or targeted gene panel testing. The specific details of the NGS test, including the sequencing platform used and the bioinformatics analysis pipeline, may vary depending on the laboratory performing the test.

For the Nx GEN SEQUENCING ALEXANDER DISEASE Test, the cost is 4680.0 AED. The test can be ordered by a neurologist or pediatrician and is performed in the Molecular Diagnostics department of DNA Labs UAE.

Symptoms and Diagnosis

The symptoms of Alexander Disease can vary widely depending on the age of onset and the specific mutations involved. Common symptoms include spasticity and seizures.

To diagnose Alexander Disease, a sample of 10 mL (5 mL minimum) whole blood from 2 Lavender Top (EDTA) tubes is required. The sample should be submitted refrigerated, without freezing. Additionally, a duly filled Whole Exome Sequencing Consent Form (Form 37) is mandatory.

The report for the Nx GEN SEQUENCING ALEXANDER DISEASE Test is delivered daily by 9 am, and the turnaround time is approximately 40 working days.

Conclusion

If you suspect Alexander Disease or want to explore genetic testing options for neurological disorders, the Nx GEN SEQUENCING ALEXANDER DISEASE Test offered by DNA Labs UAE is a reliable and comprehensive option. With advanced NGS technology and expert analysis, this test can provide valuable insights into the genetic basis of the disease. Consult with a healthcare professional or a genetic counselor for more specific information about the test and the testing process.

Test Name Nx GEN SEQUENCING ALEXANDER DISEASE Test
Components *GFAP
Price 4680.0 AED
Sample Condition Submit 10 mL (5 mL min.) whole blood from 2 Lavender Top (EDTA) tubes. Ship refrigerated. DO NOT FREEZE. Duly filled Whole Exome Sequencing Consent Form (Form 37) is mandatory.
Report Delivery Sample Daily by 9 am; Report 40 Working days
Method NGS, Sanger sequencing
Test type Genetic Disorders-Spasticity with seizures
Doctor Neurologist, Pediatrician
Test Department: MOLECULAR DIAGNOSTICS
Pre Test Information Duly filled Whole Exome Sequencing Consent Form (Form 37) is mandatory.
Test Details

Alexander Disease is a rare genetic disorder that affects the nervous system. It is caused by mutations in the GFAP gene, which encodes the glial fibrillary acidic protein. This protein is essential for the normal functioning of astrocytes, a type of brain cell.

To test for Alexander Disease, a next-generation sequencing (NGS) approach can be used. NGS allows for the simultaneous sequencing of multiple genes, making it a powerful tool for genetic testing. Here is a general overview of the steps involved in the NGS testing process for Alexander Disease:

1. Sample collection: A small sample of DNA is collected from the patient, typically through a blood sample or a cheek swab.

2. DNA extraction: The DNA is extracted from the collected sample using standard laboratory techniques.

3. Library preparation: The extracted DNA is then fragmented and prepared for sequencing. This involves attaching specific DNA adapters to the fragments, which will allow for the amplification and sequencing of the target genes.

4. Targeted sequencing: The prepared DNA library is loaded onto a sequencing instrument, such as an Illumina sequencer. The instrument will sequence the DNA fragments and generate millions of short reads.

5. Data analysis: The generated sequencing data is then analyzed using bioinformatics tools. This involves aligning the reads to a reference genome and identifying any genetic variations or mutations in the GFAP gene.

6. Variant interpretation: The identified genetic variations are then compared to known disease-causing mutations in the GFAP gene. Clinicians and geneticists will assess the significance of these variants and determine whether they are likely to be causing Alexander Disease.

It’s important to note that NGS testing can also include other genes associated with similar neurological disorders to rule out other potential causes of symptoms. Additionally, genetic testing for Alexander Disease can also be done using other techniques, such as Sanger sequencing or targeted gene panel testing.

The specific details of the NGS test, including the sequencing platform used and the bioinformatics analysis pipeline, may vary depending on the laboratory performing the test. It is recommended to consult with a healthcare professional or a genetic counselor for more specific information about the Alexander Disease test and the testing process.

SKU: TEST-4616 Category:

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