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NCF1 Gene Granulomatous Disease Chronic Autosomal Recessive Cytochrome B-Positive Type 1 Genetic Test Cost

Original price was: 5,600 د.إ.Current price is: 4,400 د.إ.

-21%

The NCF1 gene is implicated in a condition known as Granulomatous Disease, specifically the Chronic Granulomatous Disease (CGD) of the Autosomal Recessive Cytochrome b-Positive Type 1. This rare genetic disorder affects the immune system, leading to severe and recurrent infections due to the inability of phagocytes to effectively kill certain bacteria and fungi. The NCF1 gene encodes a component of the NADPH oxidase complex, which is crucial for producing reactive oxygen species used by phagocytes to destroy pathogens.

To diagnose this specific type of CGD, a genetic test targeting the NCF1 gene can be conducted. This test is crucial for confirming the diagnosis, understanding the disease’s severity, and guiding treatment decisions. It involves analyzing the patient’s DNA to identify mutations in the NCF1 gene that are responsible for the condition.

In the United Arab Emirates, this specific genetic test is available at DNA Labs UAE. The test is priced at 4400 AED. Opting for this test at DNA Labs UAE ensures that individuals suspected of having this form of CGD can receive a definitive diagnosis, which is essential for the effective management of the condition and to inform family planning decisions.

Description

NCF1 Gene Granulomatous Disease Chronic Autosomal Recessive Cytochrome b- Positive Type 1 Genetic Test

Test Details

The NCF1 gene is associated with a condition called chronic granulomatous disease (CGD), which is an inherited immune system disorder. CGD is characterized by recurrent bacterial and fungal infections due to the inability of certain white blood cells to effectively kill invading microorganisms. The NCF1 gene provides instructions for producing a protein called neutrophil cytosolic factor 1 (NCF1), which is a subunit of the NADPH oxidase enzyme complex. This complex plays a crucial role in the immune system by generating reactive oxygen species (ROS) that are necessary for the destruction of bacteria and fungi.

Mutations in the NCF1 gene can result in a non-functional or reduced-functioning NCF1 protein, leading to impaired ROS production and increased susceptibility to infections. CGD caused by mutations in the NCF1 gene is inherited in an autosomal recessive manner, meaning that both copies of the gene must be affected for the disease to manifest.

Test Components

Price: 4400.0 AED
Sample Condition: Blood or Extracted DNA or One drop Blood on FTA Card
Report Delivery: 3 to 4 Weeks
Method: NGS Technology
Test Type: Cancer
Doctor: Oncologist
Test Department: Genetics

Pre Test Information

Clinical History of Patient who is going for NCF1 Gene Granulomatous disease, chronic, autosomal recessive, cytochrome b- positive, type 1 NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with NCF1 Gene Granulomatous disease, chronic, autosomal recessive, cytochrome b- positive, type 1 NGS Genetic DNA Test gene NCF1.

Test Method

The cytochrome b-positive, type 1 NGS genetic test is a next-generation sequencing (NGS) test that can identify mutations in the NCF1 gene. This test analyzes the individual’s DNA to detect any changes or variations in the gene sequence that may be responsible for the development of CGD. By identifying mutations in the NCF1 gene, this genetic test can help confirm a diagnosis of CGD and provide information about the specific genetic cause of the disease.

Importance of the Test

This information is important for understanding the inheritance pattern, predicting the risk of CGD in family members, and guiding appropriate management and treatment strategies.

Test Name	NCF1 Gene Granulomatous disease chronic autosomal recessive cytochrome b- positive type 1 Genetic Test
Components
Price	4400.0 AED
Sample Condition	Blood or Extracted DNA or One drop Blood on FTA Card
Report Delivery	3 to 4 Weeks
Method	NGS Technology
Test type	Cancer
Doctor	Oncologist
Test Department:	Genetics
Pre Test Information	Clinical History of Patient who is going for NCF1 Gene Granulomatous disease, chronic, autosomal recessive, cytochrome b- positive, type 1 NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with NCF1 Gene Granulomatous disease, chronic, autosomal recessive, cytochrome b- positive, type 1 NGS Genetic DNA Test gene NCF1
Test Details	The NCF1 gene is associated with a condition called chronic granulomatous disease (CGD), which is an inherited immune system disorder. CGD is characterized by recurrent bacterial and fungal infections due to the inability of certain white blood cells to effectively kill invading microorganisms. The NCF1 gene provides instructions for producing a protein called neutrophil cytosolic factor 1 (NCF1), which is a subunit of the NADPH oxidase enzyme complex. This complex plays a crucial role in the immune system by generating reactive oxygen species (ROS) that are necessary for the destruction of bacteria and fungi. Mutations in the NCF1 gene can result in a non-functional or reduced-functioning NCF1 protein, leading to impaired ROS production and increased susceptibility to infections. CGD caused by mutations in the NCF1 gene is inherited in an autosomal recessive manner, meaning that both copies of the gene must be affected for the disease to manifest. The cytochrome b-positive, type 1 NGS genetic test is a next-generation sequencing (NGS) test that can identify mutations in the NCF1 gene. This test analyzes the individual’s DNA to detect any changes or variations in the gene sequence that may be responsible for the development of CGD. By identifying mutations in the NCF1 gene, this genetic test can help confirm a diagnosis of CGD and provide information about the specific genetic cause of the disease. This information is important for understanding the inheritance pattern, predicting the risk of CGD in family members, and guiding appropriate management and treatment strategies.

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