Test Price
2,800 AED✅ Home Collection Available
MSH6 Gene Colorectal Cancer, Hereditary Nonpolyposis Type 5 Genetic Test in UAE – 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity – every sample analysed in our ISO-accredited laboratory, verified by orthogonal Sanger sequencing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM). Sample viability maintained from vein to sequencer.
- Clinical Guidance: Mandatory pre- and post-test genetic counselling with our Consultant Medical Genetics to interpret your MSH6 result and plan risk‑reducing strategies.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731. We handle prior approvals for you.
Test Overview & Methodology
The MSH6 Gene Colorectal Cancer, Hereditary Nonpolyposis Type 5 Genetic Test interrogates all exons of the MSH6 mismatch repair gene for germline mutations driving Lynch syndrome. In the UAE, this definitive Next‑Generation Sequencing assay delivers a comprehensive risk assessment for colorectal, endometrial, and other Lynch‑associated cancers, enabling precision surveillance from the age of 20‑25.
| Feature | Our Test (NGS + Sanger) | Closest Alternative (Targeted SNP Array) |
|---|---|---|
| Methodology | Next‑Generation Sequencing (100x depth) + Sanger validation | SNP array – only known founder mutations |
| Analytical Sensitivity | >99.9% for single nucleotide variants & small indels | ~90% – misses rare or novel variants |
| Turnaround Time | 3–4 weeks | 1–2 weeks (but limited clinical utility) |
| Guideline Alignment | ACMG, NCCN, DHA Genetic Testing Standard | Partial – not recommended for full gene analysis |
Physician Insight & Safety Protocols
Every MSH6 result is a piece of a larger family story. A pathogenic variant elevates the lifetime risk of colorectal cancer to 15‑25% in women and 10‑20% in men, and uterine cancer risk to over 40%; therefore, early colonoscopy and prophylactic discussions are lifesaving. If you receive a negative report, remember it does not erase a strong family history – clinical correlation remains paramount.
— Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Advisory Notice
⚠️ Do Not Discontinue Prescribed Medications
Always consult your physician before making any medication changes. This genetic test is not a substitute for ongoing clinical management.
Exclusion Criteria & Red Flags
🚨 Exclusion & Emergency Red Flags
- Exclusion: Active haematologic malignancy or recent bone marrow transplant (donor DNA may confound germline analysis).
- Exclusion: Known chromosomal rearrangements disrupting the MSH6 locus that cannot be resolved by short‑read NGS.
- Red Flag: Sudden, severe abdominal pain, rectal bleeding, or unexplained weight loss – proceed to emergency department immediately; these symptoms require urgent evaluation irrespective of genetic test status.
- Red Flag: Post‑menopausal vaginal bleeding (in women with MSH6 mutation) demands urgent hysteroscopy and endometrial biopsy.
Patient FAQ & Clinical Guidance
1. What does the MSH6 NGS test actually detect, and how accurate is it?
MSH6 gene testing identifies inherited mutations causing Lynch syndrome, increasing colorectal cancer risk — this NGS test provides definitive 99.9% diagnostic accuracy. The assay reads all coding regions of the MSH6 gene with deep coverage, and every pathological variant is confirmed by Sanger sequencing, eliminating false positives. It can detect single nucleotide variants, small insertions/deletions, and copy number changes that older methods miss.
2. Who should consider the MSH6 genetic test?
Individuals with a family history of colorectal or endometrial cancer at a young age should undergo MSH6 testing. It is recommended for anyone diagnosed with colorectal cancer before age 50 or who has first‑degree relatives with Lynch‑associated cancers. Pre‑ and post‑test genetic counselling is mandatory to interpret results and plan surveillance.
3. How soon will I receive my results, and what happens after?
Results are delivered on the secure patient portal 3 to 4 weeks after sample arrival — a telephonic genetic counselling session is automatically included. Your report will classify the variant as pathogenic, likely pathogenic, uncertain significance, or benign and recommend imaging/surveillance intervals. If positive, our insurance coordinator helps activate coverage for annual colonoscopy, endometrial biopsy, and when appropriate, prophylactic surgery.
UAE Regulatory & Data Privacy Adherence
Data Protection: This test fully complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All health data is encrypted and stored in accordance with UAE law.
Medical Liability: Clinical staff adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Genetic counselling is mandatory prior to sample collection.
Clinical & Logistical Metadata
| Test Name | MSH6 Gene Colorectal Cancer, Hereditary Nonpolyposis Type 5 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or buccal swab VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM) |
| Methodology Used | Next-Generation Sequencing (100x depth) + Sanger confirmation |
| ICD-10-CM Code | Z15.09 |
| LOINC Code | 38071-4 |
| DHA Facility License & Laboratory Address | License No. 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab: DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians