Microsatellite Instability Lynch Syndrome/Colorectal Cancer Test
Cost: AED 3000.0
Symptoms, Diagnosis, and Test Details
Microsatellite instability (MSI) is a genetic condition characterized by the accumulation of errors, or mutations, in certain sections of DNA called microsatellites. These microsatellites are short repeated sequences of DNA that are prone to errors during DNA replication and repair processes.
In normal cells, DNA replication and repair mechanisms ensure that microsatellites are faithfully copied and maintained. However, in cells with MSI, these mechanisms are impaired, leading to the accumulation of errors in the microsatellite regions. This results in the instability of these DNA regions, hence the term microsatellite instability.
MSI is commonly associated with Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). Lynch syndrome is an inherited condition that predisposes individuals to various types of cancer, particularly colorectal cancer. It is caused by mutations in genes involved in DNA mismatch repair, which normally correct errors that occur during DNA replication.
When the DNA mismatch repair system is impaired due to mutations in these genes, microsatellite instability can occur. MSI is a hallmark of Lynch syndrome and is detected through laboratory testing of tumor tissue samples. Testing for MSI is an important diagnostic tool for identifying individuals at risk of Lynch syndrome and guiding appropriate cancer screening and surveillance.
Microsatellite instability is not limited to Lynch syndrome and colorectal cancer. It can also occur sporadically in certain types of tumors, including colorectal, endometrial, gastric, and ovarian cancers. In these cases, MSI may be caused by acquired mutations in DNA mismatch repair genes or other mechanisms that disrupt the normal functioning of the DNA replication and repair processes.
Understanding the presence of microsatellite instability in tumors is important for determining treatment options and predicting prognosis. Tumors with high levels of MSI tend to have a better response to immunotherapy, as the increased mutation rate can lead to the production of neoantigens that can be recognized by the immune system. Therefore, MSI testing is also used to guide treatment decisions in certain cancer types.
Test Information
- Components: Paraffin embedded tissue blocks & EDTA Vacutainer (2ml)
- Price: 3000.0 AED
- Sample Condition: Tumor tissue & Peripheral Blood
- Report Delivery: 7-8 days
- Method: Fragment Analysis
- Test Type: Genetics
- Doctor: Gynecologist
- Test Department:
Pre Test Information
Microsatellite Instability (Lynch Syndrome/Colorectal Cancer) can be done with a doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
| Test Name | Microsatellite Instability Lynch SyndromeColorectal Cancer Test |
|---|---|
| Components | Paraffin embedded tissue blocks & EDTA Vacutainer (2ml) |
| Price | 3000.0 AED |
| Sample Condition | Tumor tissue & Peripheral Blood |
| Report Delivery | 7-8 days |
| Method | Fragment Analysis |
| Test type | Genetics |
| Doctor | Gynecologist |
| Test Department: | |
| Pre Test Information | Microsatellite Instability (Lynch Syndrome/Colorectal Cancer) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
| Test Details | Microsatellite instability (MSI) is a genetic condition characterized by the accumulation of errors, or mutations, in certain sections of DNA called microsatellites. Microsatellites are short repeated sequences of DNA that are prone to errors during DNA replication and repair processes. In normal cells, DNA replication and repair mechanisms ensure that microsatellites are faithfully copied and maintained. However, in cells with MSI, these mechanisms are impaired, leading to the accumulation of errors in the microsatellite regions. This results in the instability of these DNA regions, hence the term microsatellite instability. MSI is commonly associated with Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC). Lynch syndrome is an inherited condition that predisposes individuals to various types of cancer, particularly colorectal cancer. It is caused by mutations in genes involved in DNA mismatch repair, which normally correct errors that occur during DNA replication. When the DNA mismatch repair system is impaired due to mutations in these genes, microsatellite instability can occur. MSI is a hallmark of Lynch syndrome and is detected through laboratory testing of tumor tissue samples. Testing for MSI is an important diagnostic tool for identifying individuals at risk of Lynch syndrome and guiding appropriate cancer screening and surveillance. Microsatellite instability is not limited to Lynch syndrome and colorectal cancer. It can also occur sporadically in certain types of tumors, including colorectal, endometrial, gastric, and ovarian cancers. In these cases, MSI may be caused by acquired mutations in DNA mismatch repair genes or other mechanisms that disrupt the normal functioning of the DNA replication and repair processes. Understanding the presence of microsatellite instability in tumors is important for determining treatment options and predicting prognosis. Tumors with high levels of MSI tend to have a better response to immunotherapy, as the increased mutation rate can lead to the production of neoantigens that can be recognized by the immune system. Therefore, MSI testing is also used to guide treatment decisions in certain cancer types. |
