MGMT Methylation Assay Test Price 2100 AED In Dubai Abu Dhabi UAE
Glioblastoma, a severe type of brain cancer, can be an intimidating diagnosis. Thankfully, medical advancements provide tools for individualized treatment strategies. The MGMT Methylation Assay Test is one such instrument, examining a specific gene to steer treatment choices for patients in the UAE. This article delves into the role of MGMT methylation testing in managing glioblastoma.
Deciphering MGMT Methylation:
MGMT Gene: O6-methylguanine-DNA methyltransferase (MGMT) is a gene responsible for DNA repair. In normal cells, it aids in repairing particular DNA damage. Methylation: Methylation is a natural cellular process that can deactivate genes. In glioblastoma, methylation of the MGMT gene can occur, rendering the gene inactive. Symptoms of Glioblastoma:
Seizures Headaches Challenges with speech or balance Vision issues Weakness or numbness on one side of the body Changes in personality or memory It’s crucial to remember: These symptoms can also be attributed to other conditions. It’s essential to consult a doctor for an accurate diagnosis.
Elements of the MGMT Methylation Assay Test:
The MGMT Methylation Assay Test typically examines:
MGMT Promoter Methylation: This is the main component, evaluating whether methylation has silenced the MGMT gene.
Pre-Test Details:
Who can benefit: This test is primarily utilized for patients already diagnosed with glioblastoma. Benefits: Understanding the MGMT methylation status enables doctors to customize treatment plans. For example, patients with MGMT methylation often have a better response to certain chemotherapy drugs.
Test Specifications:
Sample: A tissue sample from the tumor is typically employed. Procedure: The sample undergoes a laboratory examination to detect MGMT gene methylation. Turnaround Time: Outcomes are generally accessible within 10 business days.
Significance of the MGMT Methylation Assay Test:
Personalized Approach: Test results can assist doctors in personalizing treatment plans, maximizing effectiveness and potentially reducing side effects. Patients with MGMT methylation may benefit from specific treatment options. Informed Decisions: Comprehending your MGMT methylation status enables you to actively participate in discussions about your treatment strategy.
Accessing the MGMT Methylation Assay Test in the UAE:
The MGMT Methylation Assay Test is progressively becoming accessible at esteemed diagnostic laboratories across the UAE. It’s crucial to consult with your doctor to ascertain if this test is suitable for you. They can provide a recommendation to a reliable facility offering the test.
Steering Your Health Journey:
The MGMT Methylation Assay Test provides valuable insights for glioblastoma treatment. Discussing this option with your doctor can empower you to actively participate in your healthcare journey.
Welcome to DNA Labs UAE, where we offer the MGMT Methylation Assay Test. This laboratory test is used to detect the methylation status of the MGMT gene, which plays a crucial role in DNA repair and prevention of mutations. Read on to learn more about the test details and its applications.
Test Details
The MGMT methylation assay is a laboratory test that involves detecting the methylation status of the MGMT gene. MGMT, or O-6-methylguanine-DNA methyltransferase, is a DNA repair enzyme that removes alkyl groups from the O6 position of guanine, protecting DNA from damage and mutations.
The MGMT methylation assay typically involves bisulfite conversion of DNA, which converts unmethylated cytosines to uracils while leaving methylated cytosines unchanged. This conversion allows for the detection of methylation-specific PCR or methylation-specific qPCR to determine the methylation status of the MGMT gene.
This assay is primarily used in cancer research and clinical practice, particularly in the field of oncology. Methylation of the MGMT gene promoter region has been found to be associated with increased sensitivity to alkylating agents, such as temozolomide, which is commonly used in the treatment of glioblastoma. Therefore, the MGMT methylation assay is often used to predict the response to alkylating agents and guide treatment decisions in cancer patients.
In addition to cancer research, the MGMT methylation assay can also be used in other fields, such as neuroscience. Methylation of the MGMT gene has been implicated in neurodegenerative diseases like Parkinson’s disease and Alzheimer’s disease. Therefore, this assay has potential applications in studying the role of MGMT methylation in disease development and treatment response.
Test Components
The MGMT Methylation Assay Test requires paraffin embedded tissue blocks as the sample condition. These tissue blocks contain the necessary DNA for the test.
Price
The MGMT Methylation Assay Test is priced at 2100.0 AED.
Report Delivery
Once the test is conducted, the report will be delivered within 10-12 days.
Method
The MGMT Methylation Assay Test uses the MLPA (Multiplex Ligation-dependent Probe Amplification) method to detect the methylation status of the MGMT gene.
Test Type
The MGMT Methylation Assay Test falls under the category of Genetics tests.
Doctor
The MGMT Methylation Assay Test is conducted under the supervision of an Oncology doctor.
Test Department
The MGMT Methylation Assay Test is conducted in the Test Department of DNA Labs UAE.
Pre Test Information
The MGMT Methylation Assay Test requires a doctor’s prescription. However, the prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Thank you for choosing DNA Labs UAE for your MGMT Methylation Assay Test. Our dedicated team is committed to providing accurate and reliable results to assist in your healthcare journey.
| Test Name | MGMT Methylation Assay Test |
|---|---|
| Components | Paraffin embedded tissue blocks |
| Price | 2100.0 AED |
| Sample Condition | Tumor tissue |
| Report Delivery | 10-12 days |
| Method | MLPA |
| Test type | Genetics |
| Doctor | Oncology |
| Test Department: | |
| Pre Test Information | MGMT Methylation Assay can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
| Test Details | MGMT methylation assay is a laboratory test used to detect methylation status of the MGMT gene. MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that removes alkyl groups from the O6 position of guanine, preventing DNA damage and mutations. Methylation of the MGMT gene promoter region leads to silencing of the gene and reduced expression of the MGMT protein.
The MGMT methylation assay typically involves bisulfite conversion of DNA, which converts unmethylated cytosines to uracils while leaving methylated cytosines unchanged. This conversion allows for the detection of methylation-specific PCR or methylation-specific qPCR to determine the methylation status of the MGMT gene. The assay is primarily used in cancer research and clinical practice, particularly in the field of oncology. Methylation of the MGMT gene promoter has been found to be associated with increased sensitivity to alkylating agents, such as temozolomide, which is commonly used in the treatment of glioblastoma. Therefore, the MGMT methylation assay is often used to predict the response to alkylating agents and guide treatment decisions in cancer patients. In addition to cancer research, the MGMT methylation assay can also be used in other fields, such as neuroscience, where MGMT methylation has been implicated in neurodegenerative diseases like Parkinson’s disease and Alzheimer’s disease. Overall, the MGMT methylation assay is a valuable tool in molecular biology and clinical research for studying the epigenetic regulation of the MGMT gene and its implications in disease development and treatment response. |
