METHYLGUANINE METHYLTRANSFERASE MGMT Test
At DNA Labs UAE, we offer the METHYLGUANINE METHYLTRANSFERASE (MGMT) Test to provide valuable information for oncologists in determining the most appropriate treatment plan for cancer patients.
Test Details
The MGMT test is a laboratory test that measures the activity or levels of the enzyme methylguanine methyltransferase (MGMT) in a person’s body. MGMT is an important DNA repair enzyme that helps to remove alkyl groups from the DNA molecule. Alkylating agents, such as certain chemotherapy drugs or environmental toxins, can damage the DNA by adding alkyl groups to the DNA molecule. This can lead to DNA mutations and potentially cancer.
The MGMT test is primarily used in the field of oncology to predict the response of certain cancers to alkylating chemotherapy drugs. The test can determine the level of MGMT activity in tumor cells, which can help in determining the effectiveness of alkylating agents as a treatment option. High levels of MGMT activity in tumor cells indicate resistance to alkylating agents, while low levels suggest sensitivity to these drugs.
The MGMT test can be performed using different techniques, such as immunohistochemistry or polymerase chain reaction (PCR). Immunohistochemistry involves staining tumor tissue samples with specific antibodies to detect the presence and levels of MGMT protein. PCR, on the other hand, amplifies the DNA from tumor cells and measures the expression of the MGMT gene.
Test Cost and Components
The cost of the METHYLGUANINE METHYLTRANSFERASE MGMT Test at DNA Labs UAE is 1970.0 AED. To perform the test, please submit fresh tissue in normal saline in a sterile screw capped container. Ship the sample refrigerated and do not freeze it. Additionally, a duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Report Delivery and Test Department
The sample is required to be submitted by Monday at 11 am, and the report will be delivered within 13 working days. The MGMT test falls under the MOLECULAR DIAGNOSTICS department at DNA Labs UAE.
Pre Test Information
A duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory before performing the MGMT test.
Doctor and Test Type
The MGMT test is recommended by Oncologists and is categorized as a Cancer test.
Symptoms and Diagnosis
The MGMT test is not a diagnostic test for cancer. It is primarily used as a predictive marker to guide treatment decisions in cancer patients. The test is typically performed on tumor tissue samples obtained through biopsy or surgery.
Conclusion
The METHYLGUANINE METHYLTRANSFERASE MGMT Test plays a crucial role in personalized medicine, helping oncologists tailor treatment plans based on the individual characteristics of a patient’s tumor. By determining the level of MGMT activity in tumor cells, the test provides valuable information on the response to alkylating chemotherapy drugs. This allows for more effective treatment options and improved patient outcomes.
| Test Name | METHYLGUANINE METHYLTRANSFERASE MGMT Test |
|---|---|
| Components | |
| Price | 1970.0 AED |
| Sample Condition | Submit fresh tissue in normal saline ina sterile screw capped container. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
| Report Delivery | Sample Mon by 11 am; Report 13 Working days |
| Method | PCR |
| Test type | Cancer |
| Doctor | Oncologist |
| Test Department: | MOLECULAR DIAGNOSTICS |
| Pre Test Information | Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
| Test Details | The MGMT test is a laboratory test that measures the activity or levels of the enzyme methylguanine methyltransferase (MGMT) in a person’s body. MGMT is an important DNA repair enzyme that helps to remove alkyl groups from the DNA molecule. Alkylating agents, such as certain chemotherapy drugs or environmental toxins, can damage the DNA by adding alkyl groups to the DNA molecule. This can lead to DNA mutations and potentially cancer. The MGMT test is primarily used in the field of oncology to predict the response of certain cancers to alkylating chemotherapy drugs. The test can determine the level of MGMT activity in tumor cells, which can help in determining the effectiveness of alkylating agents as a treatment option. High levels of MGMT activity in tumor cells indicate resistance to alkylating agents, while low levels suggest sensitivity to these drugs. The MGMT test can be performed using different techniques, such as immunohistochemistry or polymerase chain reaction (PCR). Immunohistochemistry involves staining tumor tissue samples with specific antibodies to detect the presence and levels of MGMT protein. PCR, on the other hand, amplifies the DNA from tumor cells and measures the expression of the MGMT gene. The results of the MGMT test can provide valuable information to oncologists in determining the most appropriate treatment plan for cancer patients. If the test shows high MGMT activity, alternative treatment options may be considered, such as non-alkylating chemotherapy drugs or targeted therapies. Conversely, if the test shows low MGMT activity, alkylating agents may be a suitable treatment option. It is important to note that the MGMT test is not a diagnostic test for cancer. It is primarily used as a predictive marker to guide treatment decisions in cancer patients. The test is typically performed on tumor tissue samples obtained through biopsy or surgery. Overall, the MGMT test plays a crucial role in personalized medicine, helping oncologists tailor treatment plans based on the individual characteristics of a patient’s tumor. |
