Test Price
2,800 AED✅ Home Collection Available
KRT14 Gene Dermatopathia Pigmentosa Reticularis Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Genetic Counseling by a DHA-licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The KRT14 gene NGS test detects pathogenic variants responsible for Dermatopathia pigmentosa reticularis, a rare autosomal dominant ectodermal dysplasia. Using next-generation sequencing, we deliver a complete coding region analysis with unmatched precision, aiding dermatologists, clinical geneticists, and molecular pathologists in confirming the diagnosis and guiding patient management.
| Feature | Our NGS Test (KRT14 Full Gene) | Closest Alternative (Sanger Sequencing of Hotspots) |
|---|---|---|
| Methodology | NGS – full coding region & splice sites | Sanger sequencing – limited to predefined exons |
| Diagnostic Sensitivity | 99.9% for all KRT14 mutations | ~85% (misses rare or deep intronic variants) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Sample Types | Whole blood, extracted DNA, or one drop blood on FTA Card | Whole blood only (EDTA) |
Physician Insight & Safety Protocols
Advisory Notice on Medication
Do not discontinue prescribed medication without consulting your doctor. Some dermatologic therapies (e.g., retinoids, immunosuppressants) may influence test outcomes or require adjustment only under supervision. Our phlebotomy and consent processes are fully compliant with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent; active systemic infection requiring urgent intervention; recent whole blood transfusion (within 4 weeks) that may obscure germline DNA.
- ER Red Flags: Sudden blistering, high fever, or signs of skin infection at the collection site. These require immediate medical attention and do not affect test eligibility.
Patient FAQ & Clinical Guidance
1. What is the KRT14 gene and why is it linked to Dermatopathia pigmentosa reticularis?
The KRT14 gene provides instructions for making keratin 14 protein, essential for skin strength and integrity. A mutation disrupts the intermediate filaments in basal keratinocytes, leading to the characteristic reticulate hyperpigmentation, nail dystrophy, and palmoplantar keratoderma of this rare ectodermal dysplasia.
2. How is the genetic test performed and what sample do I need to provide?
A trained phlebotomist collects your sample painlessly—whole blood or a single drop on an FTA card—during a home visit using cold-chain transport. The extracted DNA is analyzed via NGS to sequence all exons of the KRT14 gene, with results reported in 3–4 weeks.
3. What do positive or negative results mean for my health and family planning?
A positive result confirms the clinical diagnosis and enables targeted surveillance for associated complications (e.g., ocular involvement). A negative result does not rule out other genodermatoses, and genetic counseling is advised for recurrence risk estimation in future pregnancies.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: This laboratory strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted and accessed only as required for clinical care.
Corporate Oversight: Operated by DNA Labs UAE, DHA Facility License No. 1143. The clinical content is reviewed by Lina Osama Zaki Quteineh (DHA 9294403).
Clinical & Logistical Metadata
| Test Name | KRT14 Gene (Dermatopathia Pigmentosa Reticularis) Full Gene Sequencing |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | Q82.8 |
| LOINC Code | 89989-4 |
| DHA Facility License & Laboratory Address | DHA License No. 1143, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE. Operated by DNA Labs UAE. |
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