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JAK 2 V617F Reflex to JAK 2 Exon 12 Mutation Detection Test

Original price was: 1,920 د.إ.Current price is: 1,730 د.إ.

-10%

The “JAK2 V617F Reflex to JAK2 Exon 12 Mutation Detection Test” is a specialized genetic test offered by DNA Labs UAE, designed to identify mutations associated with certain blood disorders, including myeloproliferative neoplasms (MPNs). This test first screens for the JAK2 V617F mutation, a common genetic alteration found in various types of MPNs. If the V617F mutation is not detected, the test then reflexes to search for mutations in exon 12 of the JAK2 gene, which could indicate other forms of MPNs.

This two-step approach ensures a comprehensive analysis for patients suspected of having MPNs, aiding in accurate diagnosis and treatment planning. The test cost is 1730 AED, reflecting the intricate technology and expertise required to perform this genetic analysis. By offering this test, DNA Labs UAE provides essential support in the diagnosis and management of blood disorders, contributing to improved patient outcomes.

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JAK 2 V617F REFLEX TO JAK 2 EXON 12 MUTATION DETECTION Test

Are you experiencing symptoms that may be related to myeloproliferative neoplasms (MPNs)? DNA Labs UAE offers the JAK 2 V617F REFLEX TO JAK 2 EXON 12 MUTATION DETECTION Test, a comprehensive laboratory test that can help diagnose and guide treatment decisions for MPNs.

Test Components and Price

The test costs AED 1730.0 and requires a sample condition of 3 mL (2 mL min.) whole blood from 1 Lavender Top (EDTA) tube. It is important to ship the sample refrigerated and not freeze it. Additionally, a duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.

Report Delivery

Sample collection should be done by Monday before 11 am, and the report will be delivered on Saturday.

Method and Test Type

The JAK 2 V617F REFLEX TO JAK 2 EXON 12 MUTATION DETECTION Test utilizes Real Time PCR and Fragment Analysis methods. It falls under the category of Cancer tests and is typically ordered by Oncologists.

Test Department

This test is conducted in the Molecular Diagnostics department of DNA Labs UAE.

Pre-Test Information

Prior to taking the test, it is mandatory to fill out the Genomics Clinical Information Requisition Form (Form 20).

Test Details

The JAK2 V617F mutation is a common genetic mutation found in patients with MPNs such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis. This mutation occurs in exon 14 of the JAK2 gene, resulting in the substitution of valine (V) with phenylalanine (F) at position 617.

Another genetic mutation that can occur in MPNs, particularly in patients with polycythemia vera, is the JAK2 exon 12 mutation. This mutation occurs in exon 12 of the JAK2 gene and activates the JAK-STAT signaling pathway, which regulates blood cell production.

The JAK2 V617F reflex to JAK2 exon 12 mutation detection test is designed to detect both the JAK2 V617F mutation and the JAK2 exon 12 mutation in patients suspected of having an MPN. This test is typically performed in patients who have a negative result for the JAK2 V617F mutation but still exhibit signs and symptoms of an MPN.

The test involves analyzing a blood or bone marrow sample to detect the presence of the JAK2 V617F mutation. If the initial test is negative for the V617F mutation, a reflex test is performed to specifically look for the JAK2 exon 12 mutation.

Detecting these mutations can confirm the diagnosis of an MPN and help guide treatment decisions. Patients with these mutations may be eligible for targeted therapies that inhibit the abnormal JAK-STAT signaling pathway, leading to improved outcomes and symptom control.

Test Name JAK 2 V617F REFLEX TO JAK 2 EXON 12 MUTATION DETECTION Test
Components
Price 1730.0 AED
Sample Condition 3 mL (2 mL min.) whole blood from 1 Lavender Top (EDTA) tube. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Report Delivery SampleMon by 11 am; Report Sat
Method Real Time PCR, Fragment Analysis
Test type Cancer
Doctor Oncologist
Test Department: MOLECULAR DIAGNOSTICS
Pre Test Information Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Test Details

The JAK2 V617F mutation is a genetic mutation that is commonly found in patients with myeloproliferative neoplasms (MPNs) such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis. This mutation occurs in exon 14 of the JAK2 gene and results in the substitution of valine (V) with phenylalanine (F) at position 617.

The JAK2 exon 12 mutation is another genetic mutation that can occur in MPNs, particularly in patients with polycythemia vera. This mutation occurs in exon 12 of the JAK2 gene and leads to the activation of the JAK-STAT signaling pathway, which is involved in the regulation of blood cell production.

The JAK2 V617F reflex to JAK2 exon 12 mutation detection test is a laboratory test that is used to detect both the JAK2 V617F mutation and the JAK2 exon 12 mutation in patients suspected of having an MPN. This test is typically performed in patients who have a negative result for the JAK2 V617F mutation but still show signs and symptoms of an MPN.

The test involves analyzing a blood or bone marrow sample from the patient to detect the presence of the JAK2 V617F mutation. If the initial test is negative for the V617F mutation, a reflex test is performed to specifically look for the JAK2 exon 12 mutation.

The detection of these mutations can help confirm the diagnosis of an MPN and guide treatment decisions. Patients with these mutations may be eligible for targeted therapies that specifically inhibit the abnormal JAK-STAT signaling pathway, leading to improved outcomes and symptom control.

SKU: TEST-5191 Category:

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