IMMUNOSUPPRESSANT DRUG PROFILE 2 Test
Test Name: IMMUNOSUPPRESSANT DRUG PROFILE 2 Test
Test Components: Cyclosporine, Sirolimus
Price: 1610.0 AED
Sample Condition: 3 mL (2 mL min.) whole blood in 1 Lavender Top (EDTA) tube. Ship refrigerated. Ideal sampling time: Just before the next dose (Trough levels). Provide date & time of sampling, dose taken & time of dosing.
Report Delivery: Sample Daily by 5 pm; Report Same day
Method: LC-MS/MS
Test type: Therapeutic Drug Monitoring
Doctor: Gastroenterologist, Nephrologist
Test Department: GENETIC
Pre Test Information: Provide date & time of sampling, dose taken & time of dosing.
Test Details
Immunosuppressant drugs are medications that suppress or weaken the immune system. They are commonly used in the treatment of autoimmune diseases, organ transplantation, and certain types of cancer. Here is a profile of a specific immunosuppressant drug:
Drug Name: Tacrolimus (Prograf)
Mechanism of Action: Tacrolimus inhibits the activity of T-lymphocytes, a type of white blood cell involved in the immune response. It works by binding to a protein called FK-binding protein-12 (FKBP-12), which inhibits the activation of calcineurin. This prevents the production of interleukin-2 (IL-2), a cytokine that stimulates T-cell proliferation and activation.
Indications: Tacrolimus is primarily used as an immunosuppressant in organ transplantation, particularly for kidney, liver, and heart transplants. It is also used in the treatment of certain autoimmune diseases, such as rheumatoid arthritis and psoriasis.
Dosage Forms: Tacrolimus is available as oral capsules, tablets, and an oral suspension. It is also available as an ointment for topical use in the treatment of eczema.
Dosage and Administration: The dosage of tacrolimus varies depending on the indication, patient’s age, weight, and kidney function. It is usually administered twice daily, with or without food. The dose may need to be adjusted based on therapeutic drug monitoring to maintain a target blood concentration.
Adverse Effects: Common side effects of tacrolimus include tremor, headache, diarrhea, nausea, vomiting, high blood pressure, and increased susceptibility to infections. Long-term use of tacrolimus may increase the risk of developing certain types of cancer, such as skin cancer and lymphoma. It may also cause kidney damage and impair glucose metabolism.
Drug Interactions: Tacrolimus can interact with several medications, including certain antibiotics, antifungals, antivirals, and drugs that affect liver enzymes. These interactions can alter the blood concentration of tacrolimus, leading to toxicity or reduced efficacy. It is important to inform the healthcare provider about all medications being taken.
Monitoring: Regular monitoring of blood levels of tacrolimus is necessary to ensure therapeutic efficacy and prevent toxicity. The target blood concentration may vary depending on the indication and time since transplantation. Other parameters, such as kidney function and blood pressure, should also be monitored regularly.
Contraindications: Tacrolimus is contraindicated in individuals with a hypersensitivity to the drug or any of its components. It should not be used in patients with uncontrolled infections or a history of malignancy, except under careful consideration and close monitoring.
Warnings and Precautions: Tacrolimus should be used with caution in patients with liver or kidney impairment, as well as in those with a history of diabetes or high blood pressure. It may increase the risk of developing opportunistic infections, such as fungal or viral infections. Patients should be advised to avoid prolonged exposure to sunlight and use appropriate sun protection due to an increased risk of skin cancer.
Overall, tacrolimus is an effective immunosuppressant drug used in organ transplantation and autoimmune diseases. However, its use requires careful monitoring and consideration of potential adverse effects and drug interactions.
| Test Name | IMMUNOSUPPRESSANT DRUG PROFILE 2 Test |
|---|---|
| Components | *Cyclosporine*Sirolimus |
| Price | 1610.0 AED |
| Sample Condition | 3 mL (2 mL min.) whole blood in 1 Lavender Top (EDTA) tube. Ship refrigerated. Ideal sampling time: Just before the next dose (Trough levels). Provide date & time of sampling, dose taken & time of dosing. |
| Report Delivery | Sample Daily by 5 pm; Report Same day |
| Method | LC-MS/MS |
| Test type | Therapeutic Drug Monitoring |
| Doctor | Gastroenterologist, Nephrologist |
| Test Department: | GENETIC |
| Pre Test Information | Provide date & time of sampling, dose taken & time of dosing. |
| Test Details |
Immunosuppressant drugs are medications that suppress or weaken the immune system. They are commonly used in the treatment of autoimmune diseases, organ transplantation, and certain types of cancer. Here is a profile of a specific immunosuppressant drug: Drug Name: Tacrolimus (Prograf) Mechanism of Action: Tacrolimus inhibits the activity of T-lymphocytes, a type of white blood cell involved in the immune response. It works by binding to a protein called FK-binding protein-12 (FKBP-12), which inhibits the activation of calcineurin. This prevents the production of interleukin-2 (IL-2), a cytokine that stimulates T-cell proliferation and activation. Indications: Tacrolimus is primarily used as an immunosuppressant in organ transplantation, particularly for kidney, liver, and heart transplants. It is also used in the treatment of certain autoimmune diseases, such as rheumatoid arthritis and psoriasis. Dosage Forms: Tacrolimus is available as oral capsules, tablets, and an oral suspension. It is also available as an ointment for topical use in the treatment of eczema. Dosage and Administration: The dosage of tacrolimus varies depending on the indication, patient’s age, weight, and kidney function. It is usually administered twice daily, with or without food. The dose may need to be adjusted based on therapeutic drug monitoring to maintain a target blood concentration. Adverse Effects: Common side effects of tacrolimus include tremor, headache, diarrhea, nausea, vomiting, high blood pressure, and increased susceptibility to infections. Long-term use of tacrolimus may increase the risk of developing certain types of cancer, such as skin cancer and lymphoma. It may also cause kidney damage and impair glucose metabolism. Drug Interactions: Tacrolimus can interact with several medications, including certain antibiotics, antifungals, antivirals, and drugs that affect liver enzymes. These interactions can alter the blood concentration of tacrolimus, leading to toxicity or reduced efficacy. It is important to inform the healthcare provider about all medications being taken. Monitoring: Regular monitoring of blood levels of tacrolimus is necessary to ensure therapeutic efficacy and prevent toxicity. The target blood concentration may vary depending on the indication and time since transplantation. Other parameters, such as kidney function and blood pressure, should also be monitored regularly. Contraindications: Tacrolimus is contraindicated in individuals with a hypersensitivity to the drug or any of its components. It should not be used in patients with uncontrolled infections or a history of malignancy, except under careful consideration and close monitoring. Warnings and Precautions: Tacrolimus should be used with caution in patients with liver or kidney impairment, as well as in those with a history of diabetes or high blood pressure. It may increase the risk of developing opportunistic infections, such as fungal or viral infections. Patients should be advised to avoid prolonged exposure to sunlight and use appropriate sun protection due to an increased risk of skin cancer. Overall, tacrolimus is an effective immunosuppressant drug used in organ transplantation and autoimmune diseases. However, its use requires careful monitoring and consideration of potential adverse effects and drug interactions. |
