Immunohistochemistry Neurofilament Polypeptide Test sale cost 410 AED
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Immunohistochemistry Neurofilament Polypeptide Test Cost

Original price was: 460 د.إ.Current price is: 410 د.إ.

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The Immunohistochemistry Neurofilament Polypeptide Test is a specialized diagnostic procedure used to detect and visualize neurofilament proteins in tissue samples. Neurofilaments are integral components of the cytoskeleton in neurons and play a critical role in maintaining the structure and function of nerve cells. This test is particularly useful in the study and diagnosis of neurological diseases and conditions, as abnormalities in neurofilament distribution or expression can be indicative of neural damage or degeneration.

Performed at DNA Labs UAE, the test utilizes immunohistochemistry techniques, which involve the application of specific antibodies that bind to neurofilament proteins. These antibodies are then visualized using a variety of detection methods, allowing for the precise localization of neurofilaments within the tissue sample. This can provide valuable insights into the pathological processes affecting the nervous system and help in the diagnosis of conditions such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and other neurodegenerative disorders.

The cost of the Immunohistochemistry Neurofilament Polypeptide Test at DNA Labs UAE is 410 AED. This fee covers the processing and analysis of the tissue sample by experienced professionals using state-of-the-art laboratory equipment. Patients and healthcare providers considering this test can expect a reliable and detailed assessment of neurofilament pathology, contributing to informed diagnosis and treatment planning for neurological conditions.

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IMMUNOHISTOCHEMISTRY NEUROFILAMENT POLYPEPTIDE Test

Test Name: IMMUNOHISTOCHEMISTRY NEUROFILAMENT POLYPEPTIDE Test

Components: Neurofilament polypeptide

Price: 410.0 AED

Sample Condition: Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. Ship at room temperature. Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Report Delivery: Sample Daily by 6 pm; Report Block: 5 days Tissue Biopsy: 5 days Tissue large complex: 7 days

Method: Immunohistochemistry

Test Type: Cancer

Doctor: Oncologist, Pathologist

Test Department: Pre Test Information

Pre Test Information: Provide a copy of the Histopathology report, Site of biopsy and Clinical history.

Test Details

Immunohistochemistry (IHC) is a technique used to detect specific proteins in tissue sections. Neurofilament polypeptides are a group of proteins found in the cytoskeleton of neurons and are involved in maintaining the structural integrity of neurons.

To perform an immunohistochemistry test for neurofilament polypeptides, the following steps are typically followed:

  1. Tissue preparation: Tissue samples, usually obtained from a biopsy or autopsy, are fixed in a suitable fixative, such as formalin, to preserve the tissue structure and proteins.
  2. Tissue sectioning: The fixed tissue is embedded in a paraffin wax block, and thin sections (usually around 4-6 micrometers thick) are cut using a microtome. These sections are then mounted onto glass slides.
  3. Antigen retrieval: Formalin fixation can mask the antigenic sites on proteins, making them inaccessible to antibodies. Antigen retrieval methods, such as heat-induced epitope retrieval (HIER) or enzymatic digestion, are used to unmask these sites and improve antibody binding.
  4. Blocking: To reduce non-specific binding of antibodies, the tissue sections are treated with a blocking solution, typically containing proteins such as bovine serum albumin or normal serum from the species the secondary antibody was raised in.
  5. Primary antibody incubation: The tissue sections are incubated with a primary antibody specific for the neurofilament polypeptide of interest. The primary antibody binds to the target protein in the tissue sections.
  6. Secondary antibody incubation: After washing off unbound primary antibody, the tissue sections are incubated with a secondary antibody conjugated to a detection system, such as an enzyme or fluorescent dye. The secondary antibody binds to the primary antibody, amplifying the signal.
  7. Visualization: If an enzyme-based detection system is used, a chromogenic substrate is added, resulting in the development of a visible color. If a fluorescent dye is used, the tissue sections are directly visualized using a fluorescence microscope.
  8. Counterstaining: To visualize the tissue structure, the tissue sections are often counterstained with dyes such as hematoxylin or eosin.
  9. Analysis: The stained tissue sections are then examined under a microscope, and the presence and distribution of the neurofilament polypeptide can be assessed.

The immunohistochemistry test for neurofilament polypeptides can provide valuable information about the presence and distribution of these proteins in neuronal tissue. It is commonly used in research and clinical settings to study neurodegenerative diseases, nerve injuries, and other neurological conditions.

Test Name IMMUNOHISTOCHEMISTRY NEUROFILAMENT POLYPEPTIDE Test
Components
Price 410.0 AED
Sample Condition Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. Ship at room temperature. Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Report Delivery Sample Daily by 6 pm; Report Block: 5 days Tissue Biopsy: 5 days Tissue large complex : 7 days
Method Immunohistochemistry
Test type Cancer
Doctor Oncologist, Pathologist
Test Department:
Pre Test Information Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Test Details

Immunohistochemistry (IHC) is a technique used to detect specific proteins in tissue sections. Neurofilament polypeptides are a group of proteins found in the cytoskeleton of neurons and are involved in maintaining the structural integrity of neurons.

To perform an immunohistochemistry test for neurofilament polypeptides, the following steps are typically followed:

1. Tissue preparation: Tissue samples, usually obtained from a biopsy or autopsy, are fixed in a suitable fixative, such as formalin, to preserve the tissue structure and proteins.

2. Tissue sectioning: The fixed tissue is embedded in a paraffin wax block, and thin sections (usually around 4-6 micrometers thick) are cut using a microtome. These sections are then mounted onto glass slides.

3. Antigen retrieval: Formalin fixation can mask the antigenic sites on proteins, making them inaccessible to antibodies. Antigen retrieval methods, such as heat-induced epitope retrieval (HIER) or enzymatic digestion, are used to unmask these sites and improve antibody binding.

4. Blocking: To reduce non-specific binding of antibodies, the tissue sections are treated with a blocking solution, typically containing proteins such as bovine serum albumin or normal serum from the species the secondary antibody was raised in.

5. Primary antibody incubation: The tissue sections are incubated with a primary antibody specific for the neurofilament polypeptide of interest. The primary antibody binds to the target protein in the tissue sections.

6. Secondary antibody incubation: After washing off unbound primary antibody, the tissue sections are incubated with a secondary antibody conjugated to a detection system, such as an enzyme or fluorescent dye. The secondary antibody binds to the primary antibody, amplifying the signal.

7. Visualization: If an enzyme-based detection system is used, a chromogenic substrate is added, resulting in the development of a visible color. If a fluorescent dye is used, the tissue sections are directly visualized using a fluorescence microscope.

8. Counterstaining: To visualize the tissue structure, the tissue sections are often counterstained with dyes such as hematoxylin or eosin.

9. Analysis: The stained tissue sections are then examined under a microscope, and the presence and distribution of the neurofilament polypeptide can be assessed.

The immunohistochemistry test for neurofilament polypeptides can provide valuable information about the presence and distribution of these proteins in neuronal tissue. It is commonly used in research and clinical settings to study neurodegenerative diseases, nerve injuries, and other neurological conditions.

SKU: TEST-6478 Category:

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