IMMUNOHISTOCHEMISTRY INI-1 Test
Components: INI-1 Test
Price: 500.0 AED
Sample Condition: Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. Ship at room temperature. Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Report Delivery: Sample Daily by 6 pm; Report Block: 5 days Tissue Biopsy: 5 days Tissue large complex: 7 days
Method: Immunohistochemistry
Test type: Cancer
Doctor: Oncologist, Pathologist
Test Department: Pre Test Information
Provide a copy of the Histopathology report, Site of biopsy and Clinical history.
Test Details
The INI-1 (Integrase Interactor 1) immunohistochemistry test is a diagnostic tool used to detect the loss of INI-1 protein expression in tumor cells. INI-1 is a tumor suppressor protein that plays a crucial role in regulating cell growth and division.
Loss of INI-1 expression is most commonly associated with a rare type of pediatric kidney cancer called malignant rhabdoid tumor (MRT). However, loss of INI-1 expression has also been observed in other tumor types, including epithelioid sarcoma and some cases of atypical teratoid/rhabdoid tumor (AT/RT).
The INI-1 immunohistochemistry test involves staining tissue sections with an antibody specific to INI-1 protein. If INI-1 protein is present in the tumor cells, it will be visualized as brown staining within the cell nucleus. Loss of INI-1 expression is indicated by the absence of nuclear staining in tumor cells.
The INI-1 immunohistochemistry test is an important tool in the diagnosis of MRT and other INI-1-deficient tumors. It can help differentiate these tumors from other malignancies that may have similar histological features. Additionally, the test can aid in identifying patients who may benefit from targeted therapies or clinical trials specifically designed for INI-1-deficient tumors.
Test Name | IMMUNOHISTOCHEMISTRY INI-1 Test |
---|---|
Components | |
Price | 500.0 AED |
Sample Condition | Submit tumor tissue in 10% Formal-saline OR Formalin fixed paraffin embedded block. Ship at room temperature. Provide a copy of the Histopathology report, Site of biopsy and Clinical history. |
Report Delivery | Sample Daily by 6 pm; Report Block: 5 days Tissue Biopsy: 5 days Tissue large complex : 7 days |
Method | Immunohistochemistry |
Test type | Cancer |
Doctor | Oncologist, Pathologist |
Test Department: | |
Pre Test Information | Provide a copy of the Histopathology report, Site of biopsy and Clinical history. |
Test Details | The INI-1 (Integrase Interactor 1) immunohistochemistry test is a diagnostic tool used to detect the loss of INI-1 protein expression in tumor cells. INI-1 is a tumor suppressor protein that plays a crucial role in regulating cell growth and division. Loss of INI-1 expression is most commonly associated with a rare type of pediatric kidney cancer called malignant rhabdoid tumor (MRT). However, loss of INI-1 expression has also been observed in other tumor types, including epithelioid sarcoma and some cases of atypical teratoid/rhabdoid tumor (AT/RT). The INI-1 immunohistochemistry test involves staining tissue sections with an antibody specific to INI-1 protein. If INI-1 protein is present in the tumor cells, it will be visualized as brown staining within the cell nucleus. Loss of INI-1 expression is indicated by the absence of nuclear staining in tumor cells. The INI-1 immunohistochemistry test is an important tool in the diagnosis of MRT and other INI-1-deficient tumors. It can help differentiate these tumors from other malignancies that may have similar histological features. Additionally, the test can aid in identifying patients who may benefit from targeted therapies or clinical trials specifically designed for INI-1-deficient tumors. |