HLA Hypersensitivity to Carbamazepine and Phenytoin B*1502 Test sale cost 1400 AED
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HLA Hypersensitivity to Carbamazepine and Phenytoin B*1502 Test Cost

Original price was: 1,560 د.إ.Current price is: 1,400 د.إ.

-10%

The HLA Hypersensitivity to Carbamazepine and Phenytoin B*1502 Test is a specialized diagnostic assessment designed to identify individuals who are at an increased risk of developing severe hypersensitivity reactions to the anticonvulsant medications carbamazepine and phenytoin. This test is particularly crucial for patients who are being considered for therapy with these drugs, as it helps in guiding clinicians to make safer prescription choices. The test works by detecting the presence of the HLA-B*1502 allele, a genetic marker strongly associated with an increased risk of adverse reactions to these medications in certain populations, particularly those of Asian descent.

Conducted at DNA Labs UAE, a facility renowned for its advanced genetic testing services, the test ensures accuracy and reliability in results. The cost of the HLA Hypersensitivity to Carbamazepine and Phenytoin B*1502 Test is 1400 AED, reflecting the sophisticated technology and expertise involved in conducting the analysis. This test represents a crucial step towards personalized medicine, enabling healthcare providers to tailor treatments to the genetic profiles of their patients, thus minimizing the risk of drug-induced hypersensitivity reactions and enhancing patient safety.

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HLA Hypersensitivity to Carbamazepine and Phenytoin B*1502 Test

Test Name: HLA Hypersensitivity to Carbamazepine and Phenytoin B*1502 Test

Test Components: PCR, Sequencing

Price: AED 1400.0

Sample Condition: 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube OR Buccal swab collected in a sterile container. Ship refrigerated. DO NOT FREEZE.

Report Delivery: 10-12 days

Test Type: Disorders of Nervous System, Disorders of Skin

Doctor: Neurologist, Dermatologist

Test Department: Pre Test Information

Pre Test Information: No special preparation required

Overview

The HLA hypersensitivity to carbamazepine and phenytoin (B*15:02) test is a genetic test used to determine an individual’s risk of developing a severe hypersensitivity reaction to the antiepileptic drugs carbamazepine and phenytoin. Carbamazepine and phenytoin are commonly used to treat epilepsy and other neurological conditions. However, in certain individuals, these drugs can cause a severe and potentially life-threatening hypersensitivity reaction known as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

The HLA-B*15:02 Gene Variant

The HLA-B*15:02 gene variant has been identified as a strong genetic risk factor for the development of SJS/TEN in response to carbamazepine and phenytoin. Individuals who carry this gene variant have a significantly higher risk of developing these severe skin reactions when exposed to these medications.

The Test Process

The HLA hypersensitivity test involves analyzing an individual’s DNA to determine whether they carry the HLA-B*15:02 gene variant. If the gene variant is detected, it indicates an increased risk of developing a severe hypersensitivity reaction to carbamazepine and phenytoin. This information can help healthcare providers make informed decisions about drug selection and avoid prescribing these medications in individuals at high risk.

Important Information

It is important to note that this test is typically recommended before starting carbamazepine or phenytoin treatment, as the risk of developing SJS/TEN is highest during the early stages of drug exposure. If an individual tests positive for the HLA-B*15:02 gene variant, alternative medications can be considered to minimize the risk of a severe hypersensitivity reaction.

Test Name HLA HYPERSENSITIVITY TO CARBAMAZEPINE and PHENYTOIN B*1502 Test
Components
Price 1400.0 AED
Sample Condition 4 mL (3 mL min.) whole blood in 1 Lavender Top (EDTA) tube OR6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube OR Buccal swab collected in a sterile container. Ship refrigerated. DO NOT FREEZE.
Report Delivery 10-12 days
Method PCR, Sequencing
Test type Disorders of Nervous System, Disorders of Skin
Doctor Neurologist, Dermatologist
Test Department:
Pre Test Information No special preparation required
Test Details

The HLA hypersensitivity to carbamazepine and phenytoin (B*15:02) test is a genetic test used to determine an individual’s risk of developing a severe hypersensitivity reaction to the antiepileptic drugs carbamazepine and phenytoin.

Carbamazepine and phenytoin are commonly used to treat epilepsy and other neurological conditions. However, in certain individuals, these drugs can cause a severe and potentially life-threatening hypersensitivity reaction known as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN).

The HLA-B*15:02 gene variant has been identified as a strong genetic risk factor for the development of SJS/TEN in response to carbamazepine and phenytoin. Individuals who carry this gene variant have a significantly higher risk of developing these severe skin reactions when exposed to these medications.

The HLA hypersensitivity test involves analyzing an individual’s DNA to determine whether they carry the HLA-B*15:02 gene variant. If the gene variant is detected, it indicates an increased risk of developing a severe hypersensitivity reaction to carbamazepine and phenytoin. This information can help healthcare providers make informed decisions about drug selection and avoid prescribing these medications in individuals at high risk.

It is important to note that this test is typically recommended before starting carbamazepine or phenytoin treatment, as the risk of developing SJS/TEN is highest during the early stages of drug exposure. If an individual tests positive for the HLA-B*15:02 gene variant, alternative medications can be considered to minimize the risk of a severe hypersensitivity reaction.

SKU: TEST-5413 Category:

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