HHH Syndrome (Hyperornithinemia-Hyperammonemia-Homocitrullinuria) Test Cost AED 1,640 in UAE
Quick Test Facts | حقائق سريعة عن الاختبار
| Parameter | Details |
|---|---|
| Test Name | HHH Syndrome (Hyperornithinemia-Hyperammonemia-Homocitrullinuria) Test |
| Test Price (AED) | AED 1,640 + Home Collection Fee: AED 100 |
| Turnaround Time (TAT) | 5 days from sample receipt at lab |
| Sample Type | 15 mL random urine (aliquot) in sterile screw‑cap container; no preservative required |
| Methodology | LC‑MS/MS, GC‑MS, DNA sequencing (SLC25A15 gene) |
| Clinical Cold‑Chain | 2‑8°C specialized transport (validated temperature‑controlled shippers) |
| Accreditation | ISO 9001:2015 (Cert. No. INT/EGQ/2509DA/3139) |
| DHA Licensed Reviewer | Dr. Prabhakar Reddy (License: 61713011) |
What is HHH Syndrome? | ما هي متلازمة فرط الأورنيثين وفرط أمونيا الدم وفرط هوموسيترولين الدم؟
HHH Syndrome (Hyperornithinemia‑Hyperammonemia‑Homocitrullinuria) is an autosomal recessive urea cycle disorder caused by pathogenic mutations in the SLC25A15 gene, which encodes the mitochondrial ornithine transporter (ORNT1). The defect leads to accumulation of ammonia, ornithine, and homocitrulline, resulting in neurological damage, developmental delay, and life‑threatening hyperammonemic crises. Early diagnosis via genetic and metabolic testing is critical for preventing irreversible brain injury.
متلازمة HHH (فرط الأورنيثين وفرط أمونيا الدم وفرط هوموسيترولين الدم) هي اضطراب وراثي جسمي متنحي في دورة اليوريا، ناتج عن طفرات في جين SLC25A15. يؤدي الخلل إلى تراكم الأمونيا والمواد السامة، مما يسبب تلفاً عصبياً وتأخراً في النمو. التشخيص المبكر بواسطة الاختبارات الجينية والتمثيل الغذائي ضروري لمنع الضرر الدماغي الدائم.
Why the Full 28‑Metabolite Panel is Critical for UAE Patients | لماذا تعتبر اللوحة الكاملة ضرورية لمرضى الإمارات؟
In the UAE’s genetically diverse population—comprising both expatriates and nationals—standard ammonia tests can yield false negatives. Our comprehensive test analyzes 28 distinct metabolic markers, including plasma ornithine, ammonia, homocitrulline, glutamine, and alanine. This approach distinguishes HHH Syndrome from other urea cycle disorders (e.g., OTCD, CPS1 deficiency) and identifies presymptomatic pediatric cases where ammonia levels are normal but ornithine is elevated. The expanded panel is particularly valuable for families with consanguinity or a history of unexplained neurodevelopmental delay, ensuring no case is missed.
Symptoms of HHH Syndrome | أعراض متلازمة HHH
- Neonatal‑Onset (~12% of cases): Lethargy, poor feeding, vomiting, tachypnea, seizures, coma.
- Infant/Childhood‑Onset: Protein aversion, failure to thrive, episodic vomiting, developmental delay, speech delay, intellectual disability.
- Adolescent/Adult‑Onset: Chronic neurocognitive deficits, acute encephalopathy, ataxia, confusion, liver dysfunction, coagulopathy.
DNA Labs UAE Cold‑Chain Protocol | بروتوكول سلسلة التبريد في مختبرات DNA الإمارات
Our 2‑8°C specialized cold‑chain logistics ensure sample integrity from home collection in Dubai, Abu Dhabi, Sharjah, and all Northern Emirates. Samples are transported in validated temperature‑monitored shippers, received at our DHCC central lab within hours, and processed immediately. This protocol prevents metabolite degradation, which is critical for accurate LC‑MS/MS quantification of ornithine, homocitrulline, and ammonia. We provide home collection services for AED 100 across the UAE, with dedicated phlebotomists trained in metabolic disorder sample handling.
Why Choose DNA Labs UAE? | لماذا تختار مختبرات DNA الإمارات؟
As a DHA‑licensed and ISO 9001:2015 accredited laboratory (Certificate No. INT/EGQ/2509DA/3139), we adhere to the highest international standards for genetic and metabolic testing. Every HHH Syndrome test is medically reviewed by Dr. Prabhakar Reddy (DHA License: 61713011), a DHA‑licensed physician specializing in clinical genetics and metabolic disorders.
Accreditation: ISO 9001:2015 Certificate (View PDF)
Our Compliance with UAE Laws | الامتثال لقوانين الإمارات
- Data Privacy (PDPL): We comply with Federal Law No. 45 of 2021 (Personal Data Protection Law) for all patient genetic and health data, ensuring strict confidentiality and secure processing.
- Medical Liability: Our practices align with Federal Decree‑Law No. 4 of 2016 on Medical Liability, guaranteeing professional accountability and patient safety.
- Health Advertising: Our content adheres to Article 87 of the UAE Health Advertisement Regulations, providing no false claims or non‑guaranteed forecasts.
- Child Digital Safety (CDS Law 2026): As HHH is often a pediatric metabolic screen, we follow the Federal Decree‑Law No. 26 of 2025 on Child Digital Safety, protecting minors’ data in all digital interactions.
Frequently Asked Questions | الأسئلة الشائعة
Q1: Is the HHH test covered by insurance in UAE?
Coverage depends on your insurance policy. Many UAE health insurers cover genetic testing for symptomatic patients with a physician’s referral. Contact your provider for pre‑authorization. We provide paid receipts for reimbursement claims.
السؤال الأول: هل يغطي التأمين تكلفة اختبار HHH في الإمارات؟
يختلف التغطية حسب وثيقة التأمين الخاصة بك. تغطي العديد من شركات التأمين الصحي في الإمارات الاختبارات الجينية للمرضى الذين يعانون من أعراض وبإحالة من الطبيب. يُرجى التواصل مع مقدم الخدمة الخاص بك للحصول على الموافقة المسبقة. نحن نقدم إيصالات مدفوعة لمطالبات السداد.
Q2: How to prepare my child for the HHH test?
Provide a brief clinical history including symptom onset, dietary protein intake, and any previous ammonia levels. For urine collection, no preservative is needed; collect in a sterile container and refrigerate until pickup. Fasting is not required for urine, but blood samples may require 4‑6 hours fasting per physician instruction.
السؤال الثاني: كيفية تحضير طفلي لاختبار HHH؟
تقديم تاريخ سريري موجز يشمل بداية الأعراض وتناول البروتين الغذائي وأي مستويات سابقة للأمونيا. لجمع البول، لا حاجة إلى مواد حافظة؛ يتم الجمع في حاوية معقمة وتبريدها حتى الاستلام. الصيام غير مطلوب للبول، ولكن عينات الدم قد تتطلب صيام 4‑6 ساعات حسب تعليمات الطبيب.
Q3: Is DNA Labs UAE results court‑admissible?
Yes. Our ISO 9001:2015 accreditation and chain‑of‑custody protocols ensure that test reports are admissible in UAE courts for inheritance, child custody, and disability claims. Results are signed by a DHA‑licensed physician.
السؤال الثالث: هل نتائج مختبرات DNA الإمارات مقبولة في المحاكم؟
نعم. تضمن شهادة ISO 9001:2015 لدينا وبروتوكولات سلسلة الحفظ أن تقارير الاختبار مقبولة في محاكم الإمارات للميراث وحضانة الأطفال ومطالبات الإعاقة. النتائج موقعة من طبيب مرخص من DHA.
Book Your HHH Syndrome Test Today | احجز اختبار متلازمة HHH اليوم
Price: AED 1,640 + Home Collection (AED 100). Turnaround time: 5 days. Call us or WhatsApp for a free consultation with a DHA‑licensed genetic counselor.
Location: Unit No 5401, Building No 49, Dubai Healthcare City (DHCC), Dubai, UAE.
📞 Call/WhatsApp: +971 54 548 8731 | Click to WhatsApp
