FISH – RARA 17q21 VARIANT TRANSLOCATION Test
Test Cost: AED 1200.0
Symptoms, Diagnosis, and Test Details
The FISH – RARA (17q21) variant translocation test is a genetic test used to detect a specific chromosomal translocation involving the RARA gene located on chromosome 17q21. This translocation is commonly found in patients with acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML).
The test uses fluorescence in situ hybridization (FISH) technique to visualize and detect the translocation. It involves labeling specific DNA probes with fluorescent dyes that bind to the RARA gene and the translocation partner gene. The labeled probes are then applied to a patient’s cells, and if the translocation is present, the probes will bind to the abnormal chromosome, producing a fluorescent signal that can be detected under a microscope.
The FISH – RARA (17q21) variant translocation test is highly specific and sensitive for detecting this specific translocation in APL patients. It is often used as a confirmatory test when APL is suspected based on clinical symptoms and other laboratory tests.
The presence of this translocation has important implications for prognosis and treatment decisions in APL patients.
Test Components and Price
- Test Name: FISH – RARA 17q21 VARIANT TRANSLOCATION Test
- Price: AED 1200.0
Sample Condition
5 mL (3 mL min.) whole blood OR 4 mL (2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22°C. DO NOT FREEZE.
Report Delivery
Sample Daily by 4 pm; Report 4 days
Method
FISH
Test Type
Cancer
Doctor
Hematologist, Oncologist
Test Department
CYTOGENETICS
Pre Test Information
Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Test Name | FISH – RARA 17q21 VARIANT TRANSLOCATION Test |
---|---|
Components | |
Price | 1200.0 AED |
Sample Condition | 5 mL (3 mL min.) whole blood OR 4 mL ( 2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22?\u00f8C. DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
Report Delivery | Sample Daily by 4 pm; Report 4 days |
Method | FISH |
Test type | Cancer |
Doctor | Hematologist, Oncologist |
Test Department: | CYTOGENETICS |
Pre Test Information | Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
Test Details |
The FISH – RARA (17q21) variant translocation test is a genetic test used to detect a specific chromosomal translocation involving the RARA gene located on chromosome 17q21. This translocation is commonly found in patients with acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML). The test uses fluorescence in situ hybridization (FISH) technique to visualize and detect the translocation. It involves labeling specific DNA probes with fluorescent dyes that bind to the RARA gene and the translocation partner gene. The labeled probes are then applied to a patient’s cells, and if the translocation is present, the probes will bind to the abnormal chromosome, producing a fluorescent signal that can be detected under a microscope. The FISH – RARA (17q21) variant translocation test is highly specific and sensitive for detecting this specific translocation in APL patients. It is often used as a confirmatory test when APL is suspected based on clinical symptoms and other laboratory tests. The presence of this translocation has important implications for prognosis and treatment decisions in APL patients. |