FISH – PDGFR BETA 5q33 GENE REARRANGEMENT Test
At DNA Labs UAE, we offer the FISH – PDGFR BETA 5q33 GENE REARRANGEMENT Test for individuals who require a diagnostic test to detect rearrangements or abnormalities in the PDGFR Beta gene located on chromosome 5q33.
Test Details
The FISH (Fluorescence In Situ Hybridization) – PDGFR Beta (5q33) gene rearrangement test is a diagnostic test used to detect rearrangements or abnormalities in the PDGFR Beta gene located on chromosome 5q33. This gene encodes for the Platelet-Derived Growth Factor Receptor Beta protein, which plays a role in cell growth and division.
The test involves using fluorescently labeled DNA probes that specifically bind to the PDGFR Beta gene region. These probes emit a fluorescent signal that can be visualized under a microscope. If there is a rearrangement or abnormality in the PDGFR Beta gene, the probes will bind to the affected region, resulting in a different fluorescent pattern compared to normal cells.
The FISH-PDGFR Beta gene rearrangement test is commonly used in the diagnosis and monitoring of certain types of cancers, such as chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). Rearrangements or abnormalities in the PDGFR Beta gene can lead to the overactivation of the PDGFR Beta protein, which can contribute to the development and progression of these cancers.
By detecting PDGFR Beta gene rearrangements, this test can help guide treatment decisions and monitor the response to targeted therapies that specifically inhibit the overactive PDGFR Beta protein.
Test Cost and Components
The cost of the FISH – PDGFR BETA 5q33 GENE REARRANGEMENT Test is AED 1200.0. The test requires a sample condition of either 5 mL (3 mL min.) whole blood or 4 mL (2 mL min.) bone marrow from 2 Green Top (Sodium Heparin) tubes. The sample should be shipped at 18-22°C and should not be frozen.
Report Delivery
The sample is collected daily by 4 pm and the report will be delivered within 4 working days.
Test Type and Doctor
The FISH – PDGFR BETA 5q33 GENE REARRANGEMENT Test falls under the category of leukemia tests. It is recommended to consult with an oncologist or hematologist for this test.
Test Department
The FISH – PDGFR BETA 5q33 GENE REARRANGEMENT Test is conducted in the CYTOGENETICS department at DNA Labs UAE.
Pre Test Information
Prior to the test, it is mandatory to fill out the Chromosome & FISH analysis Requisition Form (Form 17).
For more information or to schedule an appointment, please contact DNA Labs UAE.
| Test Name | FISH – PDGFR BETA 5q33 GENE REARRANGEMENT Test |
|---|---|
| Components | |
| Price | 1200.0 AED |
| Sample Condition | 5 mL (3 mL min.) whole blood OR 4 mL (2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22?\u00f8C. DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Report Delivery | Sample Daily by 4 pm; Report 4 Working days |
| Method | FISH |
| Test type | Leukemia |
| Doctor | Oncologist, Hematologist |
| Test Department: | CYTOGENETICS |
| Pre Test Information | Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Test Details | The FISH (Fluorescence In Situ Hybridization) – PDGFR Beta (5q33) gene rearrangement test is a diagnostic test used to detect rearrangements or abnormalities in the PDGFR Beta gene located on chromosome 5q33. This gene encodes for the Platelet-Derived Growth Factor Receptor Beta protein, which plays a role in cell growth and division. The test involves using fluorescently labeled DNA probes that specifically bind to the PDGFR Beta gene region. These probes emit a fluorescent signal that can be visualized under a microscope. If there is a rearrangement or abnormality in the PDGFR Beta gene, the probes will bind to the affected region, resulting in a different fluorescent pattern compared to normal cells. The FISH-PDGFR Beta gene rearrangement test is commonly used in the diagnosis and monitoring of certain types of cancers, such as chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GISTs). Rearrangements or abnormalities in the PDGFR Beta gene can lead to the overactivation of the PDGFR Beta protein, which can contribute to the development and progression of these cancers. By detecting PDGFR Beta gene rearrangements, this test can help guide treatment decisions and monitor the response to targeted therapies that specifically inhibit the overactive PDGFR Beta protein. |
