FISH – MDM2 12q15 GENE AMPLIFICATION Test
Test Name: FISH – MDM2 12q15 GENE AMPLIFICATION Test
Components: Price: 1640.0 AED
Sample Condition: Submit Formalin fixed paraffin embedded tissue block. Ship at room temperature. Tissue block must contain 10% tumor tissue. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Report Delivery: Sample Daily by 4 pm; Report 4 Working days
Method: FISH
Test type: Cancer
Doctor: Oncologist
Test Department: CYTOGENETICS
Pre Test Information: Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Test Details
The FISH – MDM2 (12q15) gene amplification test is a molecular diagnostic test that is used to detect amplification of the MDM2 gene on chromosome 12q15. The MDM2 gene is involved in regulating the activity of the tumor suppressor protein p53, which plays a crucial role in preventing the development of cancer.
Amplification of the MDM2 gene is commonly observed in certain types of cancer, particularly soft tissue sarcomas, including liposarcoma and well-differentiated/dedifferentiated liposarcoma. This amplification leads to overexpression of the MDM2 protein, which in turn inhibits the function of p53, allowing uncontrolled cell growth and tumor formation.
The FISH – MDM2 gene amplification test uses fluorescently labeled probes that specifically bind to the MDM2 gene on chromosome 12q15. By visualizing the fluorescence signals under a microscope, the test can determine if there is an increased number of MDM2 gene copies in the tumor cells compared to normal cells. This indicates gene amplification and suggests a potential role of MDM2 in driving the development and progression of cancer.
The FISH – MDM2 gene amplification test is often performed on tumor tissue samples obtained through biopsy or surgical resection. It can help in the diagnosis and classification of certain types of cancer, as well as guide treatment decisions. For example, in liposarcoma, the presence of MDM2 gene amplification is associated with a poorer prognosis and may indicate a potential target for therapy with MDM2 inhibitors.
Overall, the FISH – MDM2 gene amplification test is a valuable tool in molecular pathology that aids in the detection and characterization of cancer, particularly in cases where MDM2 gene amplification is suspected.
| Test Name | FISH – MDM2 12q15 GENE AMPLIFICATION Test |
|---|---|
| Components | |
| Price | 1640.0 AED |
| Sample Condition | Submit Formalin fixed paraffin embedded tissue block. Ship at room temperature. Tissue block must contain 10% tumor tissue. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Report Delivery | Sample Daily by 4 pm; Report 4 Working days |
| Method | FISH |
| Test type | Cancer |
| Doctor | Oncologist |
| Test Department: | CYTOGENETICS |
| Pre Test Information | Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Test Details |
The FISH – MDM2 (12q15) gene amplification test is a molecular diagnostic test that is used to detect amplification of the MDM2 gene on chromosome 12q15. The MDM2 gene is involved in regulating the activity of the tumor suppressor protein p53, which plays a crucial role in preventing the development of cancer. Amplification of the MDM2 gene is commonly observed in certain types of cancer, particularly soft tissue sarcomas, including liposarcoma and well-differentiated/dedifferentiated liposarcoma. This amplification leads to overexpression of the MDM2 protein, which in turn inhibits the function of p53, allowing uncontrolled cell growth and tumor formation. The FISH – MDM2 gene amplification test uses fluorescently labeled probes that specifically bind to the MDM2 gene on chromosome 12q15. By visualizing the fluorescence signals under a microscope, the test can determine if there is an increased number of MDM2 gene copies in the tumor cells compared to normal cells. This indicates gene amplification and suggests a potential role of MDM2 in driving the development and progression of cancer. The FISH – MDM2 gene amplification test is often performed on tumor tissue samples obtained through biopsy or surgical resection. It can help in the diagnosis and classification of certain types of cancer, as well as guide treatment decisions. For example, in liposarcoma, the presence of MDM2 gene amplification is associated with a poorer prognosis and may indicate a potential target for therapy with MDM2 inhibitors. Overall, the FISH – MDM2 gene amplification test is a valuable tool in molecular pathology that aids in the detection and characterization of cancer, particularly in cases where MDM2 gene amplification is suspected. |
