FISH – EWING SARCOMA EWS 22q12 EWSR1 REARRANGEMENT Test
Test Cost: AED 1520.0
Symptoms, Diagnosis, and Referring Details
The FISH – Ewing Sarcoma (EWS) 22q12 (EWSR1) rearrangement test is a type of genetic test used to detect a specific genetic rearrangement in the EWSR1 gene on chromosome 22q12. This rearrangement is commonly found in Ewing sarcoma, a type of cancer that primarily affects bone or soft tissue.
The test requires a formalin-fixed paraffin-embedded tissue block containing 10% tumor tissue. The sample should be shipped at room temperature. Additionally, a duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory for the test.
The test is conducted using the FISH method, which involves the use of fluorescent probes to bind to specific DNA sequences of interest. In this case, the probes are designed to bind to the EWSR1 gene and the region on chromosome 22q12 where the rearrangement occurs. If the EWSR1 gene is rearranged, the FISH test will show an abnormal pattern of fluorescent signals, indicating the presence of the rearrangement.
The test results are delivered within 7-8 working days. The test is performed by the CYTOGENETICS department and is typically referred by an Oncologist.
Pre Test Information
A duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory for the test.
Additional Information
It’s important to note that the FISH – Ewing Sarcoma (EWS) 22q12 (EWSR1) rearrangement test is just one of several tests used to diagnose Ewing sarcoma. Other tests, such as molecular genetic testing or immunohistochemistry, may also be performed to confirm the diagnosis and provide additional information about the tumor.
| Test Name | FISH – EWING SARCOMA EWS 22q12 EWSR1 REARRANGEMENT Test |
|---|---|
| Components | |
| Price | 1520.0 AED |
| Sample Condition | Submit Formalin fixed paraffin embedded tissue block. Ship at room temperature. Tissue block must contain 10% tumor tissue. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Report Delivery | 7-8 working days |
| Method | FISH |
| Test type | Cancer |
| Doctor | Oncologist |
| Test Department: | CYTOGENETICS |
| Pre Test Information | Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Test Details |
The FISH – Ewing Sarcoma (EWS) 22q12 (EWSR1) rearrangement test is a type of genetic test used to detect a specific genetic rearrangement in the EWSR1 gene on chromosome 22q12. This rearrangement is commonly found in Ewing sarcoma, a type of cancer that primarily affects bone or soft tissue. The test uses a technique called fluorescence in situ hybridization (FISH) to visualize and identify the presence of the EWSR1 rearrangement. In FISH, fluorescent probes are used to bind to specific DNA sequences of interest. In this case, the probes are designed to bind to the EWSR1 gene and the region on chromosome 22q12 where the rearrangement occurs. If the EWSR1 gene is rearranged, the FISH test will show an abnormal pattern of fluorescent signals, indicating the presence of the rearrangement. This information can help in diagnosing Ewing sarcoma and determining the most appropriate treatment options for the patient. It’s important to note that the FISH – Ewing Sarcoma (EWS) 22q12 (EWSR1) rearrangement test is just one of several tests used to diagnose Ewing sarcoma. Other tests, such as molecular genetic testing or immunohistochemistry, may also be performed to confirm the diagnosis and provide additional information about the tumor. |
