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FISH – BCR ABL or Philadelphia Translocation Test

960 د.إ

-10%

The FISH – BCR ABL or Philadelphia Translocation Test is a specialized diagnostic procedure designed to identify the presence of the Philadelphia chromosome or BCR-ABL gene fusion in blood or bone marrow samples. This genetic abnormality is a hallmark of chronic myeloid leukemia (CML) and some types of acute lymphoblastic leukemia (ALL), making this test crucial for accurate diagnosis and tailored treatment planning.

Fluorescence in situ hybridization (FISH) technology is utilized in this test to detect the specific genetic translocation between chromosomes 9 and 22, which results in the creation of the Philadelphia chromosome. The presence of this chromosome leads to the production of an abnormal tyrosine kinase protein that promotes uncontrolled cell division, a key feature of leukemia.

Offered by DNA Labs UAE, the test is conducted in a state-of-the-art laboratory setting by skilled professionals. With a cost of 960 AED, patients are provided with a reliable, precise, and timely analysis of their genetic status regarding the BCR-ABL fusion gene. This information is vital for oncologists to determine the most effective treatment approach, including targeted therapy options that specifically inhibit the activity of the BCR-ABL protein, thereby offering a better prognosis for patients with CML and certain types of ALL.

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FISH – BCR ABL OR PHILADELPHIA TRANSLOCATION Test

At DNA Labs UAE, we offer the FISH – BCR ABL OR PHILADELPHIA TRANSLOCATION Test to detect the presence of a specific genetic abnormality known as the Philadelphia chromosome. This test is commonly used in the diagnosis and monitoring of chronic myeloid leukemia (CML) and certain cases of acute lymphoblastic leukemia (ALL).

Test Cost

The cost of the FISH – BCR ABL OR PHILADELPHIA TRANSLOCATION Test is AED 960.0.

Symptoms and Diagnosis

Patients with chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemia (ALL) may exhibit symptoms such as fatigue, unexplained weight loss, and frequent infections. To diagnose these conditions, a sample of 5 mL (3 mL min.) whole blood or 4 mL (2 mL min.) bone marrow is required. The sample should be collected in 2 Green Top (Sodium Heparin) tubes and shipped at 18-22°C. It is important to fill out the Chromosome & FISH analysis Requisition Form (Form 17) for this test.

Report Delivery

The sample is collected daily by 4 pm, and the report will be delivered within 4 working days.

Method and Test Type

The FISH – BCR ABL OR PHILADELPHIA TRANSLOCATION Test uses the FISH (Fluorescence In Situ Hybridization) method. This test specifically targets the BCR (Breakpoint Cluster Region) and ABL (Abelson) genes, which are involved in the Philadelphia translocation. By using fluorescent probes, the test can visualize the abnormal fusion of these genes under a fluorescent microscope. The test type is leukemia.

Doctor and Test Department

This test is performed by our experienced oncologists and hematologists. The test is conducted in our Cytogenetics department.

Pre Test Information

It is mandatory to fill out the Chromosome & FISH analysis Requisition Form (Form 17) before undergoing this test.

Test Details

The FISH – BCR ABL OR PHILADELPHIA TRANSLOCATION Test is highly sensitive and specific. It can detect even small numbers of cells with the Philadelphia chromosome. This test is used to determine the presence of the Philadelphia chromosome, which occurs when a piece of chromosome 9 (containing the ABL gene) becomes attached to chromosome 22 (containing the BCR gene). This abnormality is commonly found in patients with CML and a subset of ALL.

The FISH – BCR ABL OR PHILADELPHIA TRANSLOCATION Test plays a crucial role in the diagnosis, prognosis, and monitoring of CML and certain cases of ALL. It helps guide treatment decisions and monitor the response to therapy.

Test Name FISH – BCR ABL OR PHILADELPHIA TRANSLOCATION Test
Components
Price 960.0 AED
Sample Condition 5 mL (3 mL min.) whole blood OR 4 mL ( 2 mL min.) Bone Marrow from 2 Green Top (Sodium Heparin) tubes. Ship at 18-22?\u00f8C. DO NOT FREEZE. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Report Delivery Sample Daily by 4 pm; Report 4 Working days
Method FISH
Test type Leukemia
Doctor Oncologist, Hematologist
Test Department: CYTOGENETICS
Pre Test Information Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory.
Test Details

The FISH (Fluorescence In Situ Hybridization) – BCR/ABL or Philadelphia Translocation test is a genetic test used to detect the presence of a specific genetic abnormality known as the Philadelphia chromosome. This abnormality is commonly found in patients with chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemia (ALL).

The test involves using fluorescent probes that specifically bind to the BCR (Breakpoint Cluster Region) and ABL (Abelson) genes, which are involved in the Philadelphia translocation. In normal cells, these genes are located on separate chromosomes, but in cells with the Philadelphia translocation, a piece of chromosome 9 (containing the ABL gene) becomes attached to chromosome 22 (containing the BCR gene).

By using fluorescent probes, the test can detect the presence of the Philadelphia chromosome by visualizing the abnormal fusion of the BCR and ABL genes under a fluorescent microscope. This test is highly sensitive and specific, allowing for the detection of even small numbers of cells with the Philadelphia chromosome.

The FISH – BCR/ABL or Philadelphia Translocation test is commonly used in the diagnosis and monitoring of CML and certain cases of ALL. It can help determine the prognosis of the disease, guide treatment decisions, and monitor the response to therapy.