FISH – ALK-1 BREAKAPART REARRANGEMENT Test
Welcome to DNA Labs UAE, where we offer the FISH – ALK-1 BREAKAPART REARRANGEMENT Test. This diagnostic test is used to detect specific genetic rearrangements involving the ALK gene. It is primarily used in the diagnosis and management of certain types of cancer, such as non-small cell lung cancer (NSCLC).
Test Details
The FISH (Fluorescence In Situ Hybridization) ALK-1 Breakapart Rearrangement Test involves the use of specific DNA probes that bind to the ALK gene region. These probes are labeled with different fluorescent dyes, typically green and red. In normal cells without ALK gene rearrangements, the probes will remain close together, resulting in a yellow signal when viewed under a fluorescence microscope. However, in cells with ALK gene rearrangements, the probes will be separated due to the gene fusion event. This will result in either a split signal (green and red signals apart) or an intact signal (both green and red signals together) depending on the specific rearrangement. The presence of split signals indicates the presence of ALK gene rearrangements.
The FISH ALK-1 Breakapart Rearrangement Test is useful in identifying patients who may benefit from targeted therapies that specifically target the abnormal ALK proteins. These targeted therapies, such as ALK inhibitors, can help inhibit the growth of cancer cells with ALK gene rearrangements.
It is important to note that the FISH ALK-1 Breakapart Rearrangement Test is just one of several methods used to detect ALK gene rearrangements. Other techniques, such as polymerase chain reaction (PCR) and immunohistochemistry (IHC), may also be used in conjunction with FISH for a more comprehensive assessment. The choice of testing method depends on various factors, including the type of cancer and the available laboratory resources.
Test Cost and Sample Requirements
The cost of the FISH – ALK-1 BREAKAPART REARRANGEMENT Test is 2080.0 AED. To perform the test, we require a formalin-fixed paraffin-embedded tissue block. The tissue block must contain at least 10% tumor tissue. Please ensure that you submit a duly filled Chromosome & FISH analysis Requisition Form (Form 17) along with the sample. The sample should be shipped at room temperature.
Report Delivery and Turnaround Time
The sample is processed daily, and the report is delivered within 4 working days by 4 pm.
Test Type and Doctor
The FISH – ALK-1 BREAKAPART REARRANGEMENT Test is a cancer test performed in the CYTOGENETICS department. It is typically ordered by an Oncologist.
Conclusion
The FISH – ALK-1 BREAKAPART REARRANGEMENT Test offered by DNA Labs UAE is an important diagnostic tool for detecting ALK gene rearrangements in certain types of cancer. It helps identify patients who may benefit from targeted therapies. If you suspect ALK gene rearrangements in your patients, consider ordering this test to provide them with the best possible care.
| Test Name | FISH – ALK-1 BREAKAPART REARRANGEMENT Test |
|---|---|
| Components | |
| Price | 2080.0 AED |
| Sample Condition | Submit Formalin fixed paraffin embedded tissue block. Ship at room temperature. Tissue block must contain 10% tumor tissue. Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Report Delivery | Sample Daily by 4 pm; Report 4 Working days |
| Method | FISH |
| Test type | Cancer |
| Doctor | Oncologist |
| Test Department: | CYTOGENETICS |
| Pre Test Information | Duly filled Chromosome & FISH analysis Requisition Form (Form 17) is mandatory. |
| Test Details | The FISH (Fluorescence In Situ Hybridization) ALK-1 Breakapart Rearrangement Test is a diagnostic test used to detect specific genetic rearrangements involving the ALK (Anaplastic Lymphoma Kinase) gene. This test is primarily used in the diagnosis and management of certain types of cancer, such as non-small cell lung cancer (NSCLC). The ALK gene is responsible for producing a protein that plays a role in cell growth and division. However, in some cases, the ALK gene can undergo rearrangements, resulting in the fusion of ALK with other genes. These gene fusions can lead to the production of abnormal ALK proteins that promote uncontrolled cell growth and tumor formation. The FISH ALK-1 Breakapart Rearrangement Test involves the use of specific DNA probes that bind to the ALK gene region. These probes are labeled with different fluorescent dyes, typically green and red. In normal cells without ALK gene rearrangements, the probes will remain close together, resulting in a yellow signal when viewed under a fluorescence microscope. However, in cells with ALK gene rearrangements, the probes will be separated due to the gene fusion event. This will result in either a split signal (green and red signals apart) or an intact signal (both green and red signals together) depending on the specific rearrangement. The presence of split signals indicates the presence of ALK gene rearrangements. The FISH ALK-1 Breakapart Rearrangement Test is useful in identifying patients who may benefit from targeted therapies that specifically target the abnormal ALK proteins. These targeted therapies, such as ALK inhibitors, can help inhibit the growth of cancer cells with ALK gene rearrangements. It is important to note that the FISH ALK-1 Breakapart Rearrangement Test is just one of several methods used to detect ALK gene rearrangements. Other techniques, such as polymerase chain reaction (PCR) and immunohistochemistry (IHC), may also be used in conjunction with FISH for a more comprehensive assessment. The choice of testing method depends on various factors, including the type of cancer and the available laboratory resources. |
