Familial Mediterranean Fever MEFV Full Gene Analysis Test Price 7200 AED
Understanding Familial Mediterranean Fever (FMF)
Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder primarily affecting individuals of Mediterranean descent, including those in the UAE. Characterized by recurrent episodes of fever, abdominal pain, chest pain, and arthritis, FMF can significantly impact the quality of life. The condition is caused by mutations in the MEFV gene, which encodes the protein pyrin. Pyrin plays a crucial role in controlling inflammation in the body. Mutations in this gene lead to uncontrolled inflammation, resulting in the symptoms observed in FMF.
The Role of MEFV Gene in FMF
The MEFV gene, located on chromosome 16, is responsible for producing the pyrin protein, which regulates inflammation by modulating the immune response. Mutations in the MEFV gene disrupt this regulation, causing the inflammatory episodes typical of FMF. Over 300 mutations in the MEFV gene have been identified, with specific mutations being more prevalent in certain populations.
Importance of MEFV Full Gene Analysis
MEFV full gene analysis involves sequencing the entire MEFV gene to identify any mutations present. This comprehensive approach offers several key benefits:
- Accurate Diagnosis: FMF symptoms can overlap with other autoinflammatory and autoimmune disorders, making accurate diagnosis challenging. MEFV full gene analysis provides a definitive diagnosis by identifying specific mutations responsible for FMF.
- Personalized Treatment Plans: Understanding the specific mutations in the MEFV gene allows healthcare providers to tailor treatment plans. Certain mutations may respond better to specific medications, ensuring more effective management of the condition.
- Family Planning and Genetic Counseling: For individuals with FMF or those who carry MEFV mutations, genetic counseling is crucial. MEFV full gene analysis provides essential information for family planning, helping individuals understand the risk of passing the condition to their children.
- Preventing Complications: Early and accurate diagnosis through MEFV full gene analysis can prevent complications such as amyloidosis, a condition where inflammatory proteins accumulate in organs, potentially leading to organ failure.
The Process of MEFV Full Gene Analysis
MEFV full gene analysis is typically conducted using a blood sample. The process involves several steps:
- Sample Collection: A healthcare professional collects a blood sample from the patient.
- DNA Extraction: The DNA is extracted from the blood sample in a laboratory.
- Sequencing: The MEFV gene is sequenced to identify any mutations. This involves reading the genetic code of the entire gene.
- Data Interpretation: Geneticists interpret the sequencing data to identify any mutations and their potential impact on protein function.
- Reporting: The results are compiled into a comprehensive report, detailing the identified mutations and their clinical significance.
Choosing the Right Facility for MEFV Full Gene Analysis in UAE
When considering MEFV full gene analysis, it is essential to choose a reputable facility with expertise in genetic testing and a track record of accurate results. Here are some factors to consider:
- Accreditation and Certification: Ensure the facility is accredited and certified by relevant health authorities.
- Expertise and Experience: Look for a facility with experienced geneticists and a history of conducting MEFV full gene analysis.
- Comprehensive Genetic Counseling: The facility should offer genetic counseling services to help you understand the results and their implications.
- Advanced Technology: Choose a facility that uses the latest sequencing technology for accurate and reliable results.
- Patient Support Services: Consider facilities that provide ongoing support and resources for managing FMF and related conditions.
Pre Test Information
Familial Mediterranean Fever: MEFV full gene analysis can be done with a doctor’s prescription. Please note that the prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Test Details
Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder that primarily affects people of Mediterranean origin. It is caused by mutations in the MEFV gene, which encodes for a protein called pyrin. Pyrin is involved in regulating the body’s inflammatory response.
There are more than 300 known mutations in the MEFV gene, with the most common mutations found in exons 2, 3, 5, and 10. Genetic testing for FMF typically involves sequencing these exons to identify any mutations. However, a full gene analysis of MEFV involves sequencing the entire gene, including all exons and introns. This comprehensive analysis can identify rare mutations that may not be detected by sequencing only the common exons.
A full gene analysis can also help to identify genetic variants that may contribute to disease severity or treatment response. Various genetic testing methods, such as Sanger sequencing, next-generation sequencing, and targeted gene panels, can be used to perform a full gene analysis of MEFV.
The results of genetic testing can help to confirm a diagnosis of FMF, guide treatment decisions, and provide valuable information for genetic counseling of affected individuals and their families.
Conclusion
Familial Mediterranean Fever is a complex condition requiring accurate diagnosis and personalized treatment plans. MEFV full gene analysis offers a powerful tool for achieving these goals, providing critical insights into the genetic basis of FMF. For individuals in the UAE, understanding the importance of MEFV full gene analysis and choosing the right facility can significantly impact the management and outcome of this condition. By leveraging advanced genetic testing, patients can receive more effective treatments, gain valuable information for family planning, and ultimately improve their quality of life.
Test Name: Familial Mediterranean Fever MEFV Full Gene Analysis Test
Components: EDTA Vacutainer (3 ml)
Price: 7200.0 AED
Sample Condition: Peripheral blood
Report Delivery: 4-6 weeks
Method: NGS (Next-Generation Sequencing)
Test Type: Genetics
Doctor: General Physician
Test Department: DNA Labs UAE
| Test Name | Familial Mediterranean Fever MEFV full gene Analysis Test |
|---|---|
| Components | EDTA Vacutainer (3 ml) |
| Price | 7200.0 AED |
| Sample Condition | Peripheral blood |
| Report Delivery | 4-6 weeks |
| Method | NGS |
| Test type | Genetics |
| Doctor | General Physician |
| Test Department: | |
| Pre Test Information | Familial Mediterranean Fever: MEFV full gene Analysis can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
| Test Details | Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder that primarily affects people of Mediterranean origin. It is caused by mutations in the MEFV gene, which encodes for a protein called pyrin. Pyrin is involved in regulating the body’s inflammatory response. There are more than 300 known mutations in the MEFV gene, and the most common mutations are found in exons 2, 3, 5, and 10. Genetic testing for FMF typically involves sequencing these exons to identify any mutations. However, a full gene analysis of MEFV involves sequencing the entire gene, including all exons and introns. This can identify rare mutations that may not be detected by sequencing only the common exons. A full gene analysis can also help to identify genetic variants that may contribute to disease severity or treatment response. A full gene analysis of MEFV can be performed using a variety of genetic testing methods, including Sanger sequencing, next-generation sequencing, and targeted gene panels. The results of genetic testing can help to confirm a diagnosis of FMF, guide treatment decisions, and inform genetic counseling for affected individuals and their families. |
