Test Price
2,800 AED✅ Home Collection Available
DNASE1 Gene Systemic Lupus Erythematosus Genetic Test in UAE | 2,800 AED | DHA Licensed Molecular Diagnostic
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 15189 accredited Next-Generation Sequencing processing at DNA Labs UAE.
- Premium Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM for peripheral blood specimens.
- Clinical Guidance: Telephonic post-test genetic counselling and result interpretation provided by our Consultant Medical Genetics team.
- Insurance: Direct billing verification available via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The DNASE1 Gene NGS test screens for pathogenic mutations in the DNASE1 gene associated with monogenic Systemic Lupus Erythematosus (SLE). This highly specialized molecular assay leverages massively parallel next-generation sequencing to detect single-nucleotide variants, small insertions, and deletions across all coding exons and flanking intronic regions with unmatched precision. A definitive molecular diagnosis enables rheumatologists to differentiate monogenic SLE from polygenic lupus and tailor immunosuppressive therapy accordingly.
| Feature | Our Test (NGS) | Closest Alternative (Sanger) |
|---|---|---|
| Precision | >99.9% analytical sensitivity | ~99.0% for single variant |
| Method | Massively parallel NGS | Capillary electrophoresis |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics at DNA Labs UAE, I emphasize that DNASE1 gene sequencing by NGS provides definitive molecular confirmation for monogenic SLE when clinical and serological findings are equivocal. A pathogenic DNASE1 variant confirms the diagnosis and guides immunosuppressive therapy, while a negative result does not exclude polygenic lupus. Results must always be interpreted within the complete clinical context, including autoantibody profiles and end-organ assessment.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Safety & Clinical Continuity
Do not discontinue prescribed immunosuppressant or antimalarial medication without consulting your rheumatologist. Genetic test results complement, not replace, ongoing clinical management and routine laboratory monitoring.
Patient Exclusion Criteria & Red Flags
- Acute febrile illness or active infection (may interfere with DNA quality).
- Recent blood transfusion or bone marrow transplant within 3 months.
- Known pregnancy (genetic counselling required prior to testing).
- Emergency red flags: sudden severe joint pain, chest pain, shortness of breath, or new malar rash with oral ulcers – seek immediate medical attention.
Patient FAQ & Clinical Guidance
1. What is the DNASE1 Gene Systemic Lupus Erythematosus Genetic Test?
This test uses Next-Generation Sequencing to thoroughly analyze the DNASE1 gene for mutations linked to monogenic systemic lupus erythematosus, providing a precise genetic diagnosis. It helps rheumatologists confirm SLE, differentiate it from polygenic lupus, tailor immunosuppressive therapy, and enable family risk evaluation through cascade testing.
2. How accurate is this genetic test for diagnosing monogenic SLE?
With NGS achieving >99.9% analytical sensitivity, this test detects even rare DNASE1 variants, enabling definitive genetic confirmation when clinical symptoms and autoantibody profiles align. Its high precision eliminates diagnostic uncertainty in suspected monogenic lupus cases and reduces time to appropriate therapy.
3. What is the turnaround time and cost for this test?
Results are reported within 3 to 4 weeks from sample collection. The complete test is priced at 2,800 AED, inclusive of pre-test genetic counselling, NGS analysis, and a comprehensive post-test report with variant interpretation. Our team also assists with direct insurance billing verification.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Confidentiality: All genetic data is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient genomic information is encrypted, access-controlled, and never shared without explicit written consent.
Clinical Safety & Consent: Sample collection and genetic testing procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring fully informed consent, patient autonomy, and clinical accountability at every stage.
Clinical & Logistical Metadata
| Test Name | DNASE1 Gene Systemic Lupus Erythematosus Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (NGS) – Massively parallel sequencing of coding exons and flanking intronic regions |
| ICD-10-CM Code | M32.9 (Systemic lupus erythematosus, unspecified) |
| LOINC Code | 81265-1 (DNA mutations identified in gene(s) by next-generation sequencing) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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