Chronic Neutrophilic Leukemia CNLCSF3R gene – exon 14 and 17; SETBP gene – exon 4 Test
At DNA Labs UAE, we offer a comprehensive genetic test for Chronic Neutrophilic Leukemia (CNL) that analyzes the CNLCSF3R gene – exon 14 and 17; SETBP gene – exon 4. This test is designed to provide accurate and reliable results for individuals suspected of having CNL.
Test Details
Chronic Neutrophilic Leukemia (CNL) is a rare type of blood cancer characterized by the overproduction of mature neutrophils, a type of white blood cell. It is classified as a myeloproliferative neoplasm, which involves the abnormal proliferation of bone marrow cells.
CNL is associated with specific genetic mutations, including mutations in the CSF3R gene (exon 14 and 17) and the SETBP1 gene (exon 4). The CSF3R gene provides instructions for making a receptor protein called the granulocyte colony-stimulating factor receptor (G-CSFR), which is involved in the production and maturation of neutrophils. Mutations in the CSF3R gene can lead to the overproduction of neutrophils.
The SETBP1 gene provides instructions for making a protein called SET binding protein 1, which is involved in various cellular processes, including gene regulation and cell growth. Mutations in the SETBP1 gene have been found in some cases of CNL, although their exact role in the development of the disease is still being studied.
The specific mutations in the CSF3R gene (exon 14 and 17) and the SETBP1 gene (exon 4) are considered diagnostic markers for CNL. Testing for these mutations can help confirm the diagnosis of CNL and differentiate it from other similar conditions.
Test Components
- EDTA Vacutainer (2ml)
Price
The cost of the Chronic Neutrophilic Leukemia CNLCSF3R gene – exon 14 and 17; SETBP gene – exon 4 test is 2400.0 AED.
Sample Condition
This test requires a bone marrow or peripheral blood sample.
Report Delivery
The test results will be delivered within 7-8 days.
Method
The Chronic Neutrophilic Leukemia CNLCSF3R gene – exon 14 and 17; SETBP gene – exon 4 test is performed using Sanger Sequencing.
Test Type
This is a genetics test.
Doctor
This test can be ordered by a Gynecologist.
Test Department
This test is conducted in our Genetics department.
Pre Test Information
Chronic Neutrophilic Leukemia (CNL)(CSF3R gene – exon 14 & 17; SETBP gene – exon 4) can be done with a doctor’s prescription. However, please note that a prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Treatment and Prognosis
Treatment options for CNL may include chemotherapy, targeted therapy, and bone marrow transplantation, depending on the individual case and the presence of specific genetic mutations. The prognosis for CNL varies depending on factors such as the age of the patient, the presence of other genetic mutations, and the response to treatment.
| Test Name | Chronic Neutrophilic Leukemia CNLCSF3R gene – exon 14 and 17; SETBP gene – exon 4 Test |
|---|---|
| Components | EDTA Vacutainer (2ml) |
| Price | 2400.0 AED |
| Sample Condition | Bone Marrow\/Peripheral Blood |
| Report Delivery | 7-8 days |
| Method | Sanger Sequencing |
| Test type | Genetics |
| Doctor | Gynecologist |
| Test Department: | |
| Pre Test Information | Chronic Neutrophilic Leukemia (CNL)(CSF3R gene – exon 14 & 17; SETBP gene – exon 4) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
| Test Details | Chronic Neutrophilic Leukemia (CNL) is a rare type of blood cancer characterized by the overproduction of mature neutrophils, a type of white blood cell. It is classified as a myeloproliferative neoplasm, which means that it involves the abnormal proliferation of bone marrow cells. CNL is associated with specific genetic mutations, including mutations in the CSF3R gene (exon 14 and 17) and the SETBP1 gene (exon 4). The CSF3R gene provides instructions for making a receptor protein called the granulocyte colony-stimulating factor receptor (G-CSFR), which is involved in the production and maturation of neutrophils. Mutations in the CSF3R gene can lead to the overproduction of neutrophils. The SETBP1 gene provides instructions for making a protein called SET binding protein 1, which is involved in various cellular processes, including gene regulation and cell growth. Mutations in the SETBP1 gene have been found in some cases of CNL, although their exact role in the development of the disease is still being studied. The specific mutations in the CSF3R gene (exon 14 and 17) and the SETBP1 gene (exon 4) are considered diagnostic markers for CNL. Testing for these mutations can help confirm the diagnosis of CNL and differentiate it from other similar conditions. Treatment options for CNL may include chemotherapy, targeted therapy, and bone marrow transplantation, depending on the individual case and the presence of specific genetic mutations. The prognosis for CNL varies depending on factors such as the age of the patient, the presence of other genetic mutations, and the response to treatment. |
