CALR Mutation Analysis Deletion or Insertion in Exon 9 Test sale cost 1800 AED
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CALR Mutation Analysis Deletion or Insertion in Exon 9 Test Cost

Original price was: 2,400 د.إ.Current price is: 1,800 د.إ.

-25%

The “CALR Mutation Analysis Deletion or Insertion in Exon 9 Test” is a specialized diagnostic procedure offered by DNA Labs UAE, designed to detect specific mutations within exon 9 of the CALR gene. These mutations are primarily associated with certain types of blood disorders, including myeloproliferative neoplasms (MPNs) like essential thrombocythemia (ET) and primary myelofibrosis (PMF). The test specifically looks for deletions or insertions within this region of the CALR gene, which can have significant implications for disease prognosis and treatment strategies.

Performed in a state-of-the-art laboratory setting, this analysis involves extracting DNA from a patient’s blood sample and employing sophisticated molecular techniques to scrutinize the exon 9 of the CALR gene for any aberrations. Identifying the presence of these mutations is crucial for confirming the diagnosis, aiding in risk stratification, and guiding the selection of appropriate therapeutic approaches.

The cost of the “CALR Mutation Analysis Deletion or Insertion in Exon 9 Test” at DNA Labs UAE is set at 1800 AED. This investment covers the comprehensive testing process, from sample collection to detailed genetic analysis, ensuring accurate and reliable results. Patients undergoing this test can expect a thorough examination of their CALR gene status, providing essential insights into their condition and facilitating personalized medical care.

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CALR Mutation Analysis Deletion or Insertion in Exon 9 Test

Test Name: CALR Mutation Analysis Deletion or Insertion in Exon 9 Test

Components: EDTA Vacutainer (2ml)

Price: 1800.0 AED

Sample Condition: Bone Marrow/Peripheral Blood

Report Delivery: 7-8 days

Method: Sanger Sequencing

Test Type: Genetics

Doctor: Gynecologist

Test Department:

Pre Test Information: CALR Mutation Analysis (Deletion or Insertion in Exon 9) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.

Test Details

The CALR gene is responsible for encoding the calreticulin protein, which is involved in calcium homeostasis and protein folding in the endoplasmic reticulum. Mutations in the CALR gene have been identified in various hematological malignancies, particularly in myeloproliferative neoplasms (MPNs) such as essential thrombocythemia (ET) and primary myelofibrosis (PMF).

One specific mutation in the CALR gene is a deletion or insertion in exon 9. This mutation results in a frameshift, leading to a change in the reading frame of the gene and the generation of a novel C-terminus. This mutation is mutually exclusive with other driver mutations, such as JAK2 or MPL mutations, and is found in approximately 25-30% of ET and PMF cases.

Detection of CALR exon 9 mutations can be performed using various molecular techniques, including polymerase chain reaction (PCR) followed by Sanger sequencing, allele-specific PCR, or next-generation sequencing (NGS) methods. These methods allow for the identification of the specific deletion or insertion in exon 9 and can help in the diagnosis and classification of MPNs.

The presence of CALR exon 9 mutations has been associated with specific clinical and laboratory features in MPNs. Patients with CALR mutations often have a younger age of onset, higher platelet counts, and a lower risk of thrombosis compared to those with JAK2 mutations. Additionally, CALR-mutated MPN patients may have a better overall survival compared to JAK2-mutated patients.

In conclusion, CALR mutation analysis, specifically the detection of deletions or insertions in exon 9, is an important molecular test for the diagnosis and classification of MPNs, particularly ET and PMF. This mutation is mutually exclusive with other driver mutations and has distinct clinical and laboratory features.

Test Name CALR Mutation Analysis Deletion or Insertion in Exon 9 Test
Components EDTA Vacutainer (2ml)
Price 1800.0 AED
Sample Condition Bone Marrow\/Peripheral Blood
Report Delivery 7-8 days
Method Sanger Sequencing
Test type Genetics
Doctor Gynecologist
Test Department:
Pre Test Information CALR Mutation Analysis (Deletion or Insertion in Exon 9) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

The CALR gene is responsible for encoding the calreticulin protein, which is involved in calcium homeostasis and protein folding in the endoplasmic reticulum. Mutations in the CALR gene have been identified in various hematological malignancies, particularly in myeloproliferative neoplasms (MPNs) such as essential thrombocythemia (ET) and primary myelofibrosis (PMF).

One specific mutation in the CALR gene is a deletion or insertion in exon 9. This mutation results in a frameshift, leading to a change in the reading frame of the gene and the generation of a novel C-terminus. This mutation is mutually exclusive with other driver mutations, such as JAK2 or MPL mutations, and is found in approximately 25-30% of ET and PMF cases.

Detection of CALR exon 9 mutations can be performed using various molecular techniques, including polymerase chain reaction (PCR) followed by Sanger sequencing, allele-specific PCR, or next-generation sequencing (NGS) methods. These methods allow for the identification of the specific deletion or insertion in exon 9 and can help in the diagnosis and classification of MPNs.

The presence of CALR exon 9 mutations has been associated with specific clinical and laboratory features in MPNs. Patients with CALR mutations often have a younger age of onset, higher platelet counts, and a lower risk of thrombosis compared to those with JAK2 mutations. Additionally, CALR-mutated MPN patients may have a better overall survival compared to JAK2-mutated patients.

In conclusion, CALR mutation analysis, specifically the detection of deletions or insertions in exon 9, is an important molecular test for the diagnosis and classification of MPNs, particularly ET and PMF. This mutation is mutually exclusive with other driver mutations and has distinct clinical and laboratory features.

SKU: TEST-4981 Category:

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