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BCL2IGH t14;18 Test Cost

Original price was: 2,400 د.إ.Current price is: 1,800 د.إ.

-25%

The BCL2IGH t(14;18) test is a specialized diagnostic procedure designed to detect the presence of a specific chromosomal translocation between chromosomes 14 and 18, commonly referred to as t(14;18). This translocation results in the juxtaposition of the BCL2 gene on chromosome 18 next to the immunoglobulin heavy chain locus (IGH) on chromosome 14. The consequence of this genetic rearrangement is the overexpression of the BCL2 protein, which plays a crucial role in regulating cell death and is associated with the development of certain types of cancers, most notably follicular lymphoma.

The test employs sophisticated molecular biology techniques to identify the BCL2-IGH fusion gene, providing crucial information for the diagnosis, prognosis, and management of patients with suspected or confirmed lymphomas. It is particularly valuable in the clinical setting for its role in guiding treatment decisions and monitoring disease progression or response to therapy.

Conducted at DNA Labs UAE, a reputable facility known for its advanced diagnostic services, the BCL2IGH t(14;18) test is available for a cost of 1800 AED. The lab utilizes state-of-the-art technology and follows stringent quality control measures to ensure accurate and reliable results. Patients and healthcare providers considering this test can expect professionalism and confidentiality, along with comprehensive support throughout the testing process.

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BCL2IGH t14;18 Test

Test Name: BCL2IGH t14;18 Test

Components: Paraffin embedded tissue blocks

Price: 1800.0 AED

Sample Condition: Tumor tissue

Report Delivery: 7-8 days

Method: FISH

Test Type: Genetics

Doctor: Oncology

Test Department:

Pre Test Information: BCL2/IGH (t14;18) can be done with a Doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.

Test Details

BCL2/IGH (t14;18) refers to a chromosomal translocation involving the BCL2 gene on chromosome 18 and the immunoglobulin heavy chain gene (IGH) on chromosome 14. This translocation is commonly found in certain types of B-cell lymphomas, particularly follicular lymphoma and a subset of diffuse large B-cell lymphoma.

The translocation results in the fusion of the BCL2 and IGH genes, leading to the overexpression of the BCL2 protein. BCL2 is an anti-apoptotic protein that helps regulate cell survival by preventing programmed cell death. Overexpression of BCL2 due to the translocation disrupts this balance and promotes cell survival, contributing to the development and progression of lymphomas.

The BCL2/IGH translocation can be detected using molecular genetic techniques such as fluorescence in situ hybridization (FISH) or polymerase chain reaction (PCR). Detection of this translocation is important for diagnosis and classification of lymphomas, as well as for predicting response to treatment and prognosis.

Test Name BCL2IGH t14;18 Test
Components Paraffin embedded tissue blocks
Price 1800.0 AED
Sample Condition Tumor tissue
Report Delivery 7-8 days
Method FISH
Test type Genetics
Doctor Oncology
Test Department:
Pre Test Information BCL2/IGH (t14;18) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad.
Test Details

BCL2/IGH (t14;18) refers to a chromosomal translocation involving the BCL2 gene on chromosome 18 and the immunoglobulin heavy chain gene (IGH) on chromosome 14. This translocation is commonly found in certain types of B-cell lymphomas, particularly follicular lymphoma and a subset of diffuse large B-cell lymphoma.

The translocation results in the fusion of the BCL2 and IGH genes, leading to the overexpression of the BCL2 protein. BCL2 is an anti-apoptotic protein that helps regulate cell survival by preventing programmed cell death. Overexpression of BCL2 due to the translocation disrupts this balance and promotes cell survival, contributing to the development and progression of lymphomas.

The BCL2/IGH translocation can be detected using molecular genetic techniques such as fluorescence in situ hybridization (FISH) or polymerase chain reaction (PCR). Detection of this translocation is important for diagnosis and classification of lymphomas, as well as for predicting response to treatment and prognosis.

SKU: TEST-4973 Category:

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