B-CELL REARRANGEMENT DETECTION Test
Test Name: B-CELL REARRANGEMENT DETECTION Test
Components: 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Price: 3300.0 AED
Report Delivery: 10-12 days
Method: PCR Fragment analysis
Test type: Leukemia
Doctor: Oncologist, Hematologist
Test Department: MOLECULAR DIAGNOSTICS
Pre Test Information: Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory.
Test Details
The B-cell rearrangement detection test is a diagnostic tool used to identify and evaluate abnormalities in the rearrangement of B-cell receptor genes. B-cell receptors are proteins present on the surface of B-cells, which play a crucial role in the immune response.
During the development of B-cells, their receptor genes undergo a process called V(D)J rearrangement. This process involves the rearrangement and recombination of gene segments to create a diverse repertoire of B-cell receptors capable of recognizing a wide range of antigens. However, errors or abnormalities in the rearrangement process can lead to the production of dysfunctional B-cell receptors, which can contribute to the development of certain disorders, including lymphomas and leukemias.
The B-cell rearrangement detection test involves analyzing the DNA or RNA of B-cells to identify specific rearrangements or mutations in the B-cell receptor genes. This test can help determine the clonality of B-cells, which refers to the expansion of a specific clone of B-cells due to abnormal rearrangements.
The test is typically performed using polymerase chain reaction (PCR) or next-generation sequencing techniques. PCR amplifies specific regions of the B-cell receptor genes, allowing for their detection and analysis. Next-generation sequencing provides a more comprehensive analysis of the B-cell receptor genes, allowing for the identification of a broader range of rearrangements and mutations.
The results of the B-cell rearrangement detection test can provide valuable information for diagnosing and monitoring various B-cell disorders, including lymphomas, leukemias, and autoimmune diseases. It can help determine the clonality of B-cells, assess disease progression, and guide treatment decisions.
Overall, the B-cell rearrangement detection test is an important tool in the field of immunology and can contribute to the accurate diagnosis and management of B-cell-related disorders.
Test Name | B-CELL REARRANGEMENT DETECTION Test |
---|---|
Components | |
Price | 3300.0 AED |
Sample Condition | 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube. Ship refrigerated. DO NOT FREEZE. Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
Report Delivery | 10-12 days |
Method | PCR Fragment analysis |
Test type | Leukemia |
Doctor | Oncologist, Hematologist |
Test Department: | MOLECULAR DIAGNOSTICS |
Pre Test Information | Duly filled Genomics Clinical Information Requisition Form (Form 20) is mandatory. |
Test Details |
The B-cell rearrangement detection test is a diagnostic tool used to identify and evaluate abnormalities in the rearrangement of B-cell receptor genes. B-cell receptors are proteins present on the surface of B-cells, which play a crucial role in the immune response. During the development of B-cells, their receptor genes undergo a process called V(D)J rearrangement. This process involves the rearrangement and recombination of gene segments to create a diverse repertoire of B-cell receptors capable of recognizing a wide range of antigens. However, errors or abnormalities in the rearrangement process can lead to the production of dysfunctional B-cell receptors, which can contribute to the development of certain disorders, including lymphomas and leukemias. The B-cell rearrangement detection test involves analyzing the DNA or RNA of B-cells to identify specific rearrangements or mutations in the B-cell receptor genes. This test can help determine the clonality of B-cells, which refers to the expansion of a specific clone of B-cells due to abnormal rearrangements. The test is typically performed using polymerase chain reaction (PCR) or next-generation sequencing techniques. PCR amplifies specific regions of the B-cell receptor genes, allowing for their detection and analysis. Next-generation sequencing provides a more comprehensive analysis of the B-cell receptor genes, allowing for the identification of a broader range of rearrangements and mutations. The results of the B-cell rearrangement detection test can provide valuable information for diagnosing and monitoring various B-cell disorders, including lymphomas, leukemias, and autoimmune diseases. It can help determine the clonality of B-cells, assess disease progression, and guide treatment decisions. Overall, the B-cell rearrangement detection test is an important tool in the field of immunology and can contribute to the accurate diagnosis and management of B-cell-related disorders. |