Acute Leukemia Mini Panel AMLETO INV16 PMLRARA BCRABL TELAML1 MLL E2A Test
Test Details
The Acute Leukemia Mini Panel includes the following genetic abnormalities associated with acute leukemia:
- AML/ETO: This fusion gene is formed by the translocation of genetic material between chromosomes 8 and 21. It is commonly found in Acute Myeloid Leukemia (AML) and is associated with a favorable prognosis.
- INV[16]: This genetic abnormality involves an inversion of genetic material on chromosome 16. It is associated with a subtype of AML called Acute Myelomonocytic Leukemia with Inversion 16 (AML M4Eo).
- PML/RARA: This fusion gene is formed by the translocation of genetic material between chromosomes 15 and 17. It is commonly found in Acute Promyelocytic Leukemia (APL) and is associated with a favorable prognosis.
- BCR/ABL: This fusion gene is formed by the translocation of genetic material between chromosomes 9 and 22. It is commonly found in Chronic Myeloid Leukemia (CML) and a subset of Acute Lymphoblastic Leukemia (ALL). The presence of this fusion gene is associated with a poor prognosis.
- TEL/AML1: This fusion gene is formed by the translocation of genetic material between chromosomes 12 and 21. It is commonly found in childhood Acute Lymphoblastic Leukemia (ALL) and is associated with a favorable prognosis.
- MLL: This gene, also known as MLLT1, is frequently involved in translocations with various partner genes. MLL rearrangements are commonly found in both AML and ALL and are associated with a poor prognosis.
- E2A: This gene, also known as TCF3, is involved in translocations with various partner genes. E2A rearrangements are commonly found in ALL and are associated with a poor prognosis.
These genetic abnormalities are detected using molecular genetic techniques such as polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH). Identification of these abnormalities helps in the diagnosis, risk stratification, and treatment planning for patients with acute leukemia.
Test Information
- Test Name: Acute Leukemia Mini Panel AMLETO INV16 PMLRARA BCRABL TELAML1 MLL E2A Test
- Components: EDTA Vacutainer (2ml)
- Price: 2340.0 AED
- Sample Condition: Bone marrow / Peripheral blood (Transport immediately)
- Report Delivery: 5-6 days
- Method: Real Time PCR
- Test type: Genetics
- Doctor: General Physician
- Test Department: Pre Test Information
Pre Test Information
The Acute Leukemia Mini Panel (AML/ETO, INV 16, PML/RARA, BCR/ABL, TEL/AML1, MLL, E2A) can be done with a doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Test Name | Acute Leukemia Mini Panel AMLETO INV16 PMLRARA BCRABL TELAML1 MLL E2A Test |
---|---|
Components | EDTA Vacutainer (2ml) |
Price | 2340.0 AED |
Sample Condition | Bone marrow \/ Peripheral blood (Transport immediately) |
Report Delivery | 5-6 days |
Method | Real Time PCR |
Test type | Genetics |
Doctor | General Physician |
Test Department: | |
Pre Test Information | Acute Leukemia Mini Panel (AML/ETO, INV 16], PML/RARA, BCR/ABL, TEL/AML1, MLL, E2A) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
Test Details | The Acute Leukemia Mini Panel includes the following genetic abnormalities associated with acute leukemia: 1. AML/ETO: This fusion gene is formed by the translocation of genetic material between chromosomes 8 and 21. It is commonly found in Acute Myeloid Leukemia (AML) and is associated with a favorable prognosis. 2. INV[16]: This genetic abnormality involves an inversion of genetic material on chromosome 16. It is associated with a subtype of AML called Acute Myelomonocytic Leukemia with Inversion 16 (AML M4Eo). 3. PML/RARA: This fusion gene is formed by the translocation of genetic material between chromosomes 15 and 17. It is commonly found in Acute Promyelocytic Leukemia (APL) and is associated with a favorable prognosis. 4. BCR/ABL: This fusion gene is formed by the translocation of genetic material between chromosomes 9 and 22. It is commonly found in Chronic Myeloid Leukemia (CML) and a subset of Acute Lymphoblastic Leukemia (ALL). The presence of this fusion gene is associated with a poor prognosis. 5. TEL/AML1: This fusion gene is formed by the translocation of genetic material between chromosomes 12 and 21. It is commonly found in childhood Acute Lymphoblastic Leukemia (ALL) and is associated with a favorable prognosis. 6. MLL: This gene, also known as MLLT1, is frequently involved in translocations with various partner genes. MLL rearrangements are commonly found in both AML and ALL and are associated with a poor prognosis. 7. E2A: This gene, also known as TCF3, is involved in translocations with various partner genes. E2A rearrangements are commonly found in ALL and are associated with a poor prognosis. These genetic abnormalities are detected using molecular genetic techniques such as polymerase chain reaction (PCR) or fluorescence in situ hybridization (FISH). Identification of these abnormalities helps in the diagnosis, risk stratification, and treatment planning for patients with acute leukemia. |