ABCB1 Gene Colchicine resistance Genetic Test
Test Name: ABCB1 Gene Colchicine resistance Genetic Test
Components: DNA sample from blood
Price: 4400.0 AED
Report Delivery: 3 to 4 Weeks
Method: NGS Technology
Test Type: Metabolic Disorders
Doctor: General Physician
Test Department: Genetics
Pre Test Information: Clinical History of Patient who is going for ABCB1 Gene Colchicine resistance NGS Genetic DNA Test. A Genetic Counselling session to draw a pedigree chart of family members affected with Colchicine resistance.
Test Details
The ABCB1 gene, also known as the ATP-binding cassette subfamily B member 1 gene, encodes a protein called P-glycoprotein. This protein is responsible for transporting various substances out of cells, including drugs and toxins.
Colchicine is a medication commonly used to treat gout and other inflammatory conditions. However, some individuals may be resistant to the effects of colchicine due to genetic variations in the ABCB1 gene. These variations can affect the function of P-glycoprotein, leading to decreased drug transport and reduced response to colchicine.
To determine if an individual has genetic variations in the ABCB1 gene that may confer colchicine resistance, a genetic test called Next-Generation Sequencing (NGS) can be performed. NGS is a high-throughput sequencing technology that allows for the simultaneous analysis of multiple genes or the entire genome. In the case of colchicine resistance, specific regions of the ABCB1 gene would be sequenced to identify any variations or mutations.
By identifying these genetic variations, healthcare providers can better understand an individual’s response to colchicine and tailor their treatment accordingly. This information can be particularly useful in determining the appropriate dosage of colchicine or considering alternative treatment options for individuals who are resistant to the drug.
Test Name | ABCB1 Gene Colchicine resistance Genetic Test |
---|---|
Components | |
Price | 4400.0 AED |
Sample Condition | Blood |
Report Delivery | 3 to 4 Weeks |
Method | NGS Technology |
Test type | Metabolic Disorders |
Doctor | General Physician |
Test Department: | Genetics |
Pre Test Information | Clinical History of Patient who is going for ABCB1 Gene Colchicine resistance NGS Genetic DNA Test A Genetic Counselling session to draw a pedigree chart of family members affected with Colchicine resistance |
Test Details |
The ABCB1 gene, also known as the ATP-binding cassette subfamily B member 1 gene, encodes a protein called P-glycoprotein. This protein is responsible for transporting various substances out of cells, including drugs and toxins. Colchicine is a medication commonly used to treat gout and other inflammatory conditions. However, some individuals may be resistant to the effects of colchicine due to genetic variations in the ABCB1 gene. These variations can affect the function of P-glycoprotein, leading to decreased drug transport and reduced response to colchicine. To determine if an individual has genetic variations in the ABCB1 gene that may confer colchicine resistance, a genetic test called Next-Generation Sequencing (NGS) can be performed. NGS is a high-throughput sequencing technology that allows for the simultaneous analysis of multiple genes or the entire genome. In the case of colchicine resistance, specific regions of the ABCB1 gene would be sequenced to identify any variations or mutations. By identifying these genetic variations, healthcare providers can better understand an individual’s response to colchicine and tailor their treatment accordingly. This information can be particularly useful in determining the appropriate dosage of colchicine or considering alternative treatment options for individuals who are resistant to the drug. |