Symptoms of PML RARA t(15;17)(q22;q12) Gene Rearrangement Qualitative PCR Test
Acute promyelocytic leukemia (APL) is a subtype of acute myeloid leukemia (AML), characterized by the presence of the PML RARA t(15;17)(q22;q12) gene rearrangement. This genetic anomaly results from a translocation between chromosomes 15 and 17, leading to the production of an abnormal fusion protein that plays a crucial role in the pathogenesis of the disease. Recognizing the symptoms of APL is pivotal for timely diagnosis and treatment. The PML RARA t(15;17)(q22;q12) Gene Rearrangement Qualitative PCR Test offered by DNA Labs UAE is a sophisticated diagnostic tool designed to detect this specific genetic alteration.
Patients with APL may exhibit a wide range of symptoms, often related to the disruption in normal blood cell production caused by the proliferation of abnormal promyelocytes. The following are some of the common symptoms associated with APL:
- Fatigue and Weakness: Due to anemia, a common feature in APL, resulting from reduced red blood cell counts.
- Fever: Reflecting infection, as the patient’s immune system is compromised by the decreased production of functional white blood cells.
- Bleeding and Bruising: Patients may experience easy bruising, bleeding gums, nosebleeds, and other hemorrhagic manifestations due to a deficiency in platelets (thrombocytopenia).
- Petechiae: Small red or purple spots on the body, caused by minor hemorrhages.
- Bone and Joint Pain: Caused by the expansion of the bone marrow with leukemic cells.
- Weight Loss: Unintentional weight loss may occur, although it is a less specific symptom.
The PML RARA t(15;17)(q22;q12) Gene Rearrangement Qualitative PCR Test is a crucial diagnostic tool for confirming the diagnosis of APL. By identifying the presence of the PML-RARA fusion gene, this test provides definitive evidence of the disease, facilitating prompt and appropriate treatment interventions. Early diagnosis and treatment are critical for improving the prognosis of APL, which can be highly curable with current therapies.
The cost of the PML RARA t(15;17)(q22;q12) Gene Rearrangement Qualitative PCR Test at DNA Labs UAE is 1220 AED. Considering the complexity and the sophisticated technology employed in conducting this test, the price reflects the value of obtaining an accurate and timely diagnosis. For more information and to schedule a test, please visit DNA Labs UAE.
It is important for individuals exhibiting symptoms suggestive of APL to seek medical advice promptly. The PML RARA t(15;17)(q22;q12) Gene Rearrangement Qualitative PCR Test is a valuable diagnostic resource, providing crucial information that can guide the management and treatment of this condition. With the support of advanced diagnostic tools like those offered by DNA Labs UAE, patients have a better chance of achieving a positive outcome.
