Leukocyte Adhesion Deficiency (LAD) is a rare, autosomal recessive immune disorder that affects the body’s ability to combat infections. The ITGB1 gene plays a pivotal role in this condition, and genetic testing for mutations in this gene can provide crucial information for diagnosis and management. DNA Labs UAE offers a comprehensive genetic test for the ITGB1 gene to help identify individuals with or at risk of developing LAD.
Symptoms of ITGB1 Gene Leukocyte Adhesion Deficiency
Leukocyte Adhesion Deficiency (LAD) caused by mutations in the ITGB1 gene presents with a variety of symptoms, primarily related to the immune system’s impaired ability to fight infections. The most common symptoms include:
- Delayed wound healing: Individuals with LAD may experience significantly delayed healing of wounds due to the inability of leukocytes to reach the site of injury.
- Recurrent bacterial infections: Patients often suffer from recurrent, severe bacterial infections that are difficult to treat because of the immune system’s compromised function.
- Periodontal disease: Severe gum disease is a hallmark of LAD, often leading to early loss of teeth in affected children and adults.
- Omphalitis: Newborns with LAD may present with infections of the umbilical stump, which can be severe and life-threatening.
- Leukocytosis: High levels of white blood cells (leukocytes) are typically observed in the bloodstream, as they are unable to migrate to sites of infection or injury.
Early recognition of these symptoms is crucial for the timely diagnosis and management of LAD. Genetic testing plays a pivotal role in confirming the diagnosis and facilitating appropriate treatment and counseling.
ITGB1 Gene Leukocyte Adhesion Deficiency Genetic Test
DNA Labs UAE offers a comprehensive genetic test for the ITGB1 gene, aimed at identifying mutations associated with Leukocyte Adhesion Deficiency. This test is an invaluable tool for individuals presenting with symptoms of LAD, families with a history of the disorder, and couples considering pregnancy. The genetic test involves a simple blood sample from which DNA is extracted and analyzed for specific mutations in the ITGB1 gene.
Test Cost
The cost of the ITGB1 gene Leukocyte Adhesion Deficiency genetic test at DNA Labs UAE is 4400 AED. This price includes the cost of the sample collection, DNA extraction, genetic analysis, and a comprehensive report that explains the results. The report also provides recommendations for follow-up and, if necessary, genetic counseling sessions to discuss the implications of the test results.
Conclusion
Leukocyte Adhesion Deficiency is a serious condition that significantly impacts the quality of life and requires early diagnosis and management. The ITGB1 gene genetic test offered by DNA Labs UAE is a critical step in the diagnosis and understanding of this disorder. With a cost of 4400 AED, this test provides valuable information for affected individuals and their families, guiding treatment and management decisions. For more information or to schedule a test, visit DNA Labs UAE.
