In the realm of medical genetics, the understanding and identification of specific gene rearrangements play a crucial role in diagnosing and managing various diseases, particularly those of hematological origin. Among these, the inversion 16 (inv(16) p13q22) or t(16;16)(p13;q22) gene rearrangement stands out for its association with acute myeloid leukemia (AML), specifically the M4Eo subtype. This article delves into the symptoms associated with this genetic anomaly, the significance of the Inv16 p13q22 t(16;16)p13q22 Gene Rearrangement Qualitative PCR Test, and its cost at DNA Labs UAE.
Understanding Inv16 p13q22 t(16;16)p13q22 Gene Rearrangement
The inv(16) p13q22 or t(16;16)(p13;q22) gene rearrangement is a chromosomal abnormality often associated with a specific type of acute myeloid leukemia (AML) known as the M4Eo subtype. This rearrangement involves the inversion or translocation of genetic material between chromosome 16’s p and q arms. The clinical significance of detecting this rearrangement lies in its association with a favorable prognosis in AML patients, making it imperative for accurate diagnosis and targeted therapy.
Symptoms of AML Associated with Inv16 p13q22 t(16;16)p13q22
Acute myeloid leukemia (AML) with inv(16) or t(16;16) gene rearrangement typically presents with symptoms common to AML, which may include:
- Fatigue and weakness due to anemia
- Fever and infections resulting from neutropenia
- Bleeding or bruising tendencies owing to thrombocytopenia
- Weight loss and night sweats
- Bone pain and tenderness
- Gum hypertrophy and skin lesions, particularly in cases of M4Eo subtype
It is crucial for individuals presenting with these symptoms to undergo diagnostic testing to confirm the presence of AML and identify any specific genetic abnormalities, such as the inv(16) p13q22 or t(16;16)(p13;q22) gene rearrangement.
Inv16 p13q22 t(16;16)p13q22 Gene Rearrangement Qualitative PCR Test
The Inv16 p13q22 t(16;16)p13q22 Gene Rearrangement Qualitative PCR Test is a sophisticated diagnostic tool employed to detect the specific gene rearrangement associated with a subtype of acute myeloid leukemia. Utilizing the polymerase chain reaction (PCR) technique, this test amplifies segments of DNA to identify the presence of the inv(16) or t(16;16) rearrangement. The accuracy and speed of PCR make it an invaluable tool in the early diagnosis and management of AML.
Test Cost and Availability at DNA Labs UAE
At DNA Labs UAE, the cost of the Inv16 p13q22 t(16;16)p13q22 Gene Rearrangement Qualitative PCR Test is set at 980 AED. This price is reflective of the sophisticated nature of the test and the invaluable insights it provides into the patient’s specific type of AML, guiding treatment decisions. For more information or to schedule a test, visit DNA Labs UAE.
Conclusion
The identification of specific gene rearrangements, such as inv(16) p13q22 or t(16;16)(p13;q22), plays a pivotal role in the diagnosis and treatment of acute myeloid leukemia. The Inv16 p13q22 t(16;16)p13q22 Gene Rearrangement Qualitative PCR Test offered by DNA Labs UAE represents a critical tool in the arsenal against AML, offering hope and direction for affected individuals. Understanding the symptoms associated with this genetic anomaly and the importance of early and accurate diagnosis cannot be overstated, making this test an essential component of modern hematological oncology.
