Immunohistochemistry (IHC) is a critical technique used in pathology to detect specific antigens in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues. The IHC IgG4 test is particularly significant in diagnosing diseases related to IgG4-related disease (IgG4-RD), a fibro-inflammatory condition marked by the tendency to form tumefactive lesions in various organs including the pancreas, biliary tree, salivary glands, orbit, and lymph nodes. This article explores the symptoms that might prompt an Immunohistochemistry IgG4 test, and discusses the cost of this test at DNA Labs UAE.
Understanding IgG4-Related Disease
IgG4-Related Disease (IgG4-RD) is a relatively recent clinical entity characterized by a chronic inflammatory condition that can affect multiple organs. The hallmark of this disease is the infiltration of IgG4-positive plasma cells. The disease often presents in a tumor-like manner, making it a challenging condition to diagnose without specific tests.
Why an Immunohistochemistry IgG4 Test is Important
The Immunohistochemistry IgG4 test plays a crucial role in diagnosing IgG4-RD. By detecting IgG4-positive plasma cells in tissue samples, this test helps differentiate IgG4-RD from other diseases that may present similarly, such as cancer or autoimmune diseases. This differentiation is vital for determining the appropriate treatment plan.
Symptoms Prompting an Immunohistochemistry IgG4 Test
Several symptoms and conditions may lead a healthcare provider to recommend an Immunohistochemistry IgG4 test. These include:
- Unexplained swelling or masses in the pancreas, salivary glands, or other organs
- Jaundice, which is often a result of bile duct obstruction
- Persistent dry mouth or dry eyes, suggesting involvement of the salivary or lacrimal glands
- Unexplained lymphadenopathy (enlargement of lymph nodes)
- Recurrent or persistent sinusitis or rhinitis, which may indicate nasal or sinus involvement
- Weight loss, fatigue, and fever, which are general indicators of chronic inflammatory or autoimmune conditions
It is important to note that these symptoms are not exclusive to IgG4-RD and can be associated with various other conditions. Thus, the Immunohistochemistry IgG4 test becomes a critical diagnostic tool.
Test Cost at DNA Labs UAE
The cost of an Immunohistochemistry IgG4 test at DNA Labs UAE is set at 500 AED. Considering the detailed analysis and the specific expertise required to perform this test, the price reflects the value it provides in diagnosing complex conditions like IgG4-RD. For more information on the test and to schedule an appointment, visit DNA Labs UAE.
Conclusion
Immunohistochemistry IgG4 testing is a pivotal diagnostic tool in the identification of IgG4-Related Disease, a complex condition that can affect multiple organs and mimic various other diseases. Recognizing the symptoms that may prompt this specific test is crucial for early diagnosis and treatment. DNA Labs UAE offers this specialized test, aiding in the accurate diagnosis of IgG4-RD and facilitating appropriate treatment plans for affected individuals.
