Immunohistochemistry (IHC) is a crucial technique used in pathology and research to detect specific antigens (proteins) in cells of a tissue section. It exploits the principle of antibodies binding specifically to antigens in biological tissues. The Immunohistochemistry Cytokeratin-7 (CK-7) test is a specific application of this technology, aimed at detecting the presence of CK-7 protein. Cytokeratin-7 is a type of keratin, which is a protein present in the intermediate filaments of the epithelial cells. The expression of CK-7 can be an important diagnostic marker for various types of cancer, including those of the breast, ovary, lung, and pancreas.
Symptoms Leading to the Recommendation of CK-7 Test
The recommendation for a CK-7 test often arises from the clinical suspicion of certain types of cancers. It’s important to understand that the test itself does not diagnose cancer but is used as a tool to help identify the tissue of origin in cancers of unknown primary (CUP) and to classify tumors more accurately. Some symptoms that might lead a physician to recommend a CK-7 test include:
- Unexplained weight loss
- Chronic cough or changes in cough pattern
- Abdominal pain or bloating
- Irregularities in breast tissue or nipple discharge
- Persistent pain in the side or back
- Changes in bowel or bladder habits
- Unusual gynecological symptoms or bleeding
Understanding the CK-7 Test Process
The CK-7 test is performed on a tissue sample, which is usually obtained through a biopsy of the suspected tumor. The tissue is then processed and stained with specific antibodies against CK-7. If the CK-7 protein is present, it will bind to the antibodies, which can then be visualized under a microscope, often with the aid of a colored or fluorescent marker.
Significance of CK-7 in Diagnosing Diseases
The presence or absence of CK-7 can provide valuable information regarding the type and origin of a tumor. For instance, CK-7 is typically expressed in tumors originating from the breast, ovary, lung, and pancreas but is usually not found in those of the colon. Therefore, a positive CK-7 test might suggest a primary tumor in one of the former organs, especially if correlated with clinical findings and other diagnostic tests.
Cost of the CK-7 Test
The cost of the Immunohistochemistry Cytokeratin-7 (CK-7) test at DNA Labs UAE is 410 AED. This cost is subject to change and may vary based on additional factors such as the need for more extensive testing or consultation fees. It’s advisable to check the latest prices and any applicable insurance coverage or discounts.
Conclusion
Understanding the symptoms that may lead to the recommendation of a CK-7 test is crucial for patients and healthcare providers alike. This test serves as a valuable tool in the diagnostic process, particularly in identifying the tissue of origin in cancers of unknown primary. With a cost of 410 AED at DNA Labs UAE, it is accessible for patients seeking advanced diagnostic options. Remember, an early and accurate diagnosis is key to effective treatment and better outcomes in cancer care.
