In the realm of genetic testing, the FISH – RARA 17q21 Variant Translocation Test stands out as a pivotal diagnostic tool for identifying specific genetic abnormalities. This test, offered by DNA Labs UAE, is especially crucial for patients suspected of having certain types of leukemia, where early detection can significantly influence treatment decisions and outcomes. Understanding the symptoms that may necessitate this test, its procedural intricacies, and the associated costs is essential for patients and healthcare providers alike.
Symptoms Leading to the FISH – RARA 17q21 Variant Translocation Test
The decision to proceed with the FISH – RARA 17q21 Variant Translocation Test is often predicated on the presence of symptoms indicative of acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML). These symptoms may include, but are not limited to:
- Unexplained bruising or bleeding, such as frequent nosebleeds, bleeding gums, or heavy menstrual periods.
- Persistent fatigue or weakness, which may be attributed to anemia.
- Fever or frequent infections, signaling an abnormality in the white blood cell count.
- Weight loss or loss of appetite without a clear reason.
- Discomfort or pain in bones or joints.
- Shortness of breath during light physical activity or even at rest.
It is crucial to note that these symptoms are not exclusive to APL and can be associated with a variety of health conditions. However, their presence, especially in combination, warrants a thorough medical evaluation, including genetic testing like the FISH – RARA 17q21 Variant Translocation Test, to rule out or confirm a diagnosis of APL.
About the FISH – RARA 17q21 Variant Translocation Test
The FISH (Fluorescence In Situ Hybridization) – RARA 17q21 Variant Translocation Test is a sophisticated diagnostic tool used to detect the presence of the PML-RARA gene fusion. This genetic anomaly is the result of a translocation between chromosomes 15 and 17, specifically at the locations 15q24 and 17q21. The presence of this gene fusion is a hallmark of APL, and its identification is critical for confirming the diagnosis and guiding treatment decisions.
This test employs fluorescent probes to bind to specific DNA sequences on chromosomes 15 and 17. The resulting fluorescent signals can be visualized under a microscope, allowing for the identification of the PML-RARA translocation. This level of specificity makes the FISH – RARA 17q21 Variant Translocation Test an invaluable asset in the diagnosis and management of APL.
Cost and Accessibility of the Test
The cost of the FISH – RARA 17q21 Variant Translocation Test at DNA Labs UAE is set at 1200 AED. This price reflects the advanced technology and expertise required to perform the test and interpret its results accurately. Patients interested in undergoing this test can find more information and initiate the testing process by visiting DNA Labs UAE.
Conclusion
The FISH – RARA 17q21 Variant Translocation Test is a cornerstone in the diagnosis of acute promyelocytic leukemia, offering a precise method for detecting the PML-RARA gene fusion. Recognizing the symptoms that may indicate the need for this test, understanding its procedural details, and being aware of its cost are crucial steps for patients and healthcare providers. Early detection and accurate diagnosis are paramount in the effective treatment of APL, and the FISH – RARA 17q21 Variant Translocation Test plays a pivotal role in achieving these objectives.
