Alkaptonuria is a rare genetic disorder, which can significantly impact an individual’s quality of life if left undiagnosed or untreated. It is caused by a deficiency of the enzyme homogentisate 1,2-dioxygenase, which leads to the accumulation of homogentisic acid in the body. This accumulation can cause darkening of the urine, ochronosis (blue-black pigmentation in connective […]











