Gastrointestinal stromal tumors (GISTs) represent a unique subset of cancers that originate from the digestive tract’s connective tissue or, less frequently, from the omentum, mesentery, or retroperitoneum. The discovery of mutations in the Platelet-Derived Growth Factor Receptor Alpha (PDGFRA) and the proto-oncogene cKIT (CD117) has significantly advanced our understanding of the pathogenesis of these tumors. […]











