HLA PRE-TRANSPLANT WORKUP SENSITIZED RECIPIENT PANEL 4 Test
Test Name: HLA PRE-TRANSPLANT WORKUP SENSITIZED RECIPIENT PANEL 4 Test
Components:
- HLA DNA Typing for Kidney / Liver transplant, High resolution NGS
- HLA T & B cell lymphocyte cross match vs potential donor
- HLA T & B cell lymphocyte flow cytometry cross match vs potential donor
- HLA Panel Reactive IgG antibodies (PRA) Screen Luminex
- Single antigen bead (SAB) IgG Class I & II Luminex
Price: 14040.0 AED
Sample Condition:
- RECIPIENT: 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube AND 9 mL (6 mL min.) serum from 3 SST’s AND 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube AND 4 mL (2 mL min.) whole blood in 1 Green Top (Sodium Heparin) tube.
- Collect specimen preferably 48 hours after dialysis.
- Ship at 18-22°C. DO NOT REFRIGERATE OR FREEZE.
- Doctor’s prescription on the letterhead with 1 photograph each of recipient and donor duly stamped AND Consent form for HLA Typing for Solid organ transplant (Form 33) is mandatory.
Report Delivery: 10-12 days
Method: Complement Dependent Cytotoxicity with DTT treatment, Reverse SSOP – Luminex, Luminex X-Map technology, Flow cytometry, Sequence based Typing (SBT)
Test Type: Transplantation
Doctor: Nephrologist
Test Department:
Pre Test Information: Doctor’s prescription on the letterhead with 1 photograph each of recipient and donor duly stamped AND Consent form for HLA Typing for Solid organ transplant (Form 33) is mandatory.
Test Details:
The sensitized recipient panel 4 (SRP4) test is a blood test that is used to determine the level of antibodies in a potential organ transplant recipient’s blood. This test is typically performed as part of the pre-transplant workup for individuals who have been sensitized to human leukocyte antigens (HLA). HLA are proteins that are found on the surface of cells in the body. These proteins help the immune system distinguish between “self” cells and “foreign” cells. When a person receives a blood transfusion or an organ transplant, their immune system may recognize the HLA on the donor cells as foreign and mount an immune response against them. This immune response can lead to rejection of the transplanted organ.
The SRP4 test is used to determine the level of antibodies in the recipient’s blood that may react with the donor’s HLA. This information can help the transplant team select a donor organ that is less likely to be rejected by the recipient’s immune system. The SRP4 test is performed using a panel of HLA antigens that are commonly found in the population. The recipient’s blood is mixed with the HLA antigens, and any antibodies in the recipient’s blood that react with the antigens are detected using a special technique called flow cytometry.
The results of the SRP4 test are reported as a percentage of the panel that the recipient is sensitized to. For example, if the recipient is sensitized to 50% of the panel, it means that they have antibodies that react with half of the HLA antigens tested. The transplant team will use the results of the SRP4 test, along with other factors such as the recipient’s medical history and the availability of donor organs, to determine the best course of treatment for the individual. In some cases, the transplant may be postponed or the recipient may be treated with medications to reduce their antibody levels before the transplant can take place.
Test Name | HLA PRE-TRANSPLANT WORKUP SENSITIZED RECIPIENT PANEL 4 Test |
---|---|
Components | Recipient : *HLA DNA Typing for Kidney / Liver transplant,High resolution NGS *HLA T & B cell lymphocyte cross match vs potential donor* HLA T & B cell lymphocyte flow cytometry cross match vs potential donor *HLA Panel Reactive IgG antibodies (PRA) Screen Luminex *Single antigen bead (SAB) IgG Class I & II Luminex |
Price | 14040.0 AED |
Sample Condition | RECIPIENT: 6 mL (3 mL min.) whole blood in 1 Yellow Top (ACD) tube AND 9 mL (6 mL min.) serum from 3 SST’s AND 4 mL (2 mL min.) whole blood in 1 Lavender top (EDTA) tube AND 4 mL (2 mL min.) whole blood in 1 Green Top (Sodium Heparin) tube. Collect specimen preferably 48 hours after dialysis. Ship at 18\u0192??22?\u00f8C. DO NOT REFRIGERATE OR FREEZE.Doctor’s prescription on the letter head with 1 photograph each of recipient and donor duly stamped AND Consent form for HLA Typing for Solid organ transplant (Form 33) is mandatory. |
Report Delivery | 10-12 days |
Method | Complement Dependent Cytotoxicity with DTT treatment, Reverse SSOP – Luminex, Luminex X-Map technology, Flow cytometry, Sequence based Typing (SBT) |
Test type | Transplantation |
Doctor | Nephrologist |
Test Department: | |
Pre Test Information | Doctor’s prescription on the letter head with 1 photograph each of recipient and donor duly stamped AND Consent form for HLA Typing for Solid organ transplant (Form 33) is mandatory. |
Test Details |
The sensitized recipient panel 4 (SRP4) test is a blood test that is used to determine the level of antibodies in a potential organ transplant recipient’s blood. This test is typically performed as part of the pre-transplant workup for individuals who have been sensitized to human leukocyte antigens (HLA). HLA are proteins that are found on the surface of cells in the body. These proteins help the immune system distinguish between “self” cells and “foreign” cells. When a person receives a blood transfusion or an organ transplant, their immune system may recognize the HLA on the donor cells as foreign and mount an immune response against them. This immune response can lead to rejection of the transplanted organ. The SRP4 test is used to determine the level of antibodies in the recipient’s blood that may react with the donor’s HLA. This information can help the transplant team select a donor organ that is less likely to be rejected by the recipient’s immune system. The SRP4 test is performed using a panel of HLA antigens that are commonly found in the population. The recipient’s blood is mixed with the HLA antigens, and any antibodies in the recipient’s blood that react with the antigens are detected using a special technique called flow cytometry. The results of the SRP4 test are reported as a percentage of the panel that the recipient is sensitized to. For example, if the recipient is sensitized to 50% of the panel, it means that they have antibodies that react with half of the HLA antigens tested. The transplant team will use the results of the SRP4 test, along with other factors such as the recipient’s medical history and the availability of donor organs, to determine the best course of treatment for the individual. In some cases, the transplant may be postponed or the recipient may be treated with medications to reduce their antibody levels before the transplant can take place. |