DNA Labs UAE is at the forefront of genetic testing and diagnostics, offering a comprehensive range of services designed to provide insights into various genetic conditions and predispositions. Among the myriad of tests offered, the UGT1A1 Gene Polymorphism Nucleotide ‘TA’ Repeats Detection Test stands out for its significance in predicting and managing certain medical conditions. This test, priced at 1290 AED, is pivotal for individuals looking to understand their genetic predisposition to conditions influenced by the UGT1A1 gene.
Understanding UGT1A1 Gene Polymorphism
The UGT1A1 gene is crucial in the body’s process of glucuronidation, a metabolic pathway essential for the detoxification and elimination of various endogenous and exogenous compounds, including bilirubin and certain drugs. Polymorphisms in the UGT1A1 gene, particularly in the promoter region where a variable number of nucleotide (TA) repeats occur, can significantly impact the gene’s expression levels. The most common polymorphism involves an increase in the number of TA repeats, typically resulting in reduced enzyme activity.
Symptoms and Conditions Associated with UGT1A1 Polymorphism
Individuals with variations in the UGT1A1 gene may experience a range of symptoms and conditions, primarily related to the body’s ability to process bilirubin and certain medications. These can include:
- Jaundice: An increase in bilirubin levels can lead to jaundice, characterized by a yellowing of the skin and eyes.
- Gilbert’s Syndrome: This mild liver disorder, often inherited, results in an increased level of bilirubin in the blood, leading to jaundice.
- Drug Toxicity: Reduced UGT1A1 activity can lead to an increased risk of toxicity from certain medications, including irinotecan, a chemotherapy drug.
Importance of the UGT1A1 Gene Polymorphism Detection Test
The UGT1A1 Gene Polymorphism Nucleotide ‘TA’ Repeats Detection Test is a critical tool for individuals who are at risk of conditions associated with the UGT1A1 gene polymorphism. By identifying the number of TA repeats in the UGT1A1 gene, healthcare providers can tailor medical treatment to reduce the risk of drug toxicity and manage conditions like Gilbert’s Syndrome more effectively. This test is particularly recommended for patients who are about to undergo treatments with drugs known to be metabolized by the UGT1A1 enzyme.
Test Procedure and Cost
The test is conducted using a simple blood sample, making it a non-invasive procedure. Once the sample is collected, it is analyzed in the state-of-the-art laboratories of DNA Labs UAE to determine the number of TA repeats in the UGT1A1 gene’s promoter region. The cost of the test is 1290 AED, an investment in personal health that provides invaluable information for managing and preventing potential health issues associated with UGT1A1 polymorphism.
Conclusion
The UGT1A1 Gene Polymorphism Nucleotide ‘TA’ Repeats Detection Test is a vital tool in the field of personalized medicine. It empowers individuals and healthcare providers with crucial information that can guide treatment decisions and health management strategies. DNA Labs UAE is proud to offer this test as part of its commitment to providing advanced genetic testing services. For more information on this test and to schedule an appointment, visit DNA Labs UAE.
