Leukocyte adhesion deficiency type 3 (LAD3) is a rare genetic disorder that affects the immune system’s ability to function properly. It is caused by mutations in the FERMT3 gene, which plays a crucial role in the process of leukocytes (white blood cells) adhering to the blood vessel walls. This adhesion is essential for the immune response, including the ability of the body to fight infections and heal wounds. Understanding the symptoms of this condition is critical for early diagnosis and treatment.
Symptoms of FERMT3 Gene Leukocyte Adhesion Deficiency Type 3
Individuals with LAD3 can exhibit a wide range of symptoms, which may vary in severity. The most common signs and symptoms include:
- Delayed wound healing: Wounds may take longer to heal, and when they do, they often heal poorly.
- Recurrent bacterial infections: Individuals with LAD3 are more susceptible to bacterial infections, which can be more severe and frequent than usual.
- Periodontitis and severe gum disease: This can lead to early tooth loss and may be one of the first signs of the condition in some individuals.
- Persistent leukocytosis: An abnormally high number of white blood cells in the blood, as the cells are unable to exit the bloodstream to fight infections in tissues.
- Skin lesions: These may appear without any apparent cause and can be difficult to treat.
- Omphalitis: A severe infection of the umbilical stump in newborns, which can be a sign of LAD3.
It’s important to note that the severity and presence of these symptoms can vary significantly among affected individuals. Some may have mild symptoms that go unnoticed, while others may experience life-threatening infections from an early age.
Genetic Testing for FERMT3 Gene Mutation
Genetic testing for mutations in the FERMT3 gene is crucial for diagnosing leukocyte adhesion deficiency type 3. DNA Labs UAE offers a comprehensive genetic test for this purpose. This test can confirm the diagnosis, allowing for appropriate management and treatment strategies to be implemented. Furthermore, it can provide essential information for family planning and the assessment of carrier status in family members.
Test Cost
The cost of the FERMT3 gene leukocyte adhesion deficiency type 3 genetic test at DNA Labs UAE is 4400 AED. This investment covers the full spectrum of services, from sample collection to detailed analysis and reporting. It’s a critical step towards personalized care for individuals suspected of having LAD3 or those with a family history of the condition.
Why Choose DNA Labs UAE?
DNA Labs UAE is a leading provider of genetic testing services in the United Arab Emirates. With state-of-the-art facilities and a team of expert geneticists, the lab offers accurate and reliable results. Their commitment to excellence ensures that each test is conducted with the utmost care and precision, providing individuals and families with the information they need to make informed health decisions.
For more information on the FERMT3 gene leukocyte adhesion deficiency type 3 genetic test, or to schedule a test, please visit https://dnalabsuae.com/tests/fermt3-gene-leukocyte-adhesion-deficiency-type-3-genetic-test/.
Understanding the symptoms and genetic basis of LAD3 is essential for early diagnosis and treatment. With the support of DNA Labs UAE, individuals and families affected by this condition can access comprehensive testing services, paving the way for better health outcomes and quality of life.
