Keratosis palmoplantaris striata type 1, also known as striate palmoplantar keratoderma (SPPK), is a rare genetic skin disorder characterized by the development of thickened skin (keratoderma) on the palms of the hands and the soles of the feet. This condition is caused by mutations in the DSG1 gene, which plays a crucial role in skin cell adhesion and integrity. Understanding the symptoms of this genetic condition is essential for early diagnosis and management. DNA Labs UAE offers a comprehensive genetic test for the DSG1 gene mutation, allowing individuals and families to determine their risk for this condition.
Symptoms of DSG1 Gene Keratosis Palmoplantaris Striata Type 1
The symptoms of Keratosis palmoplantaris striata type 1 can vary widely among affected individuals, but they typically include:
- Striate Keratoderma: The hallmark of this condition, striate keratoderma involves the development of linear, ridge-like thickening of the skin on the palms and soles. These ridges can be yellowish, brown, or skin-colored.
- Skin Dryness and Scaling: Affected areas may also exhibit dryness and scaling, which can contribute to discomfort and cracking of the skin.
- Pain and Discomfort: The thickened skin can lead to pain, especially when walking or using the hands for daily activities. This discomfort can impact the quality of life and daily functioning.
- Increased Sweating: Hyperhidrosis, or increased sweating, is often observed in the affected areas, which can exacerbate skin problems.
- Onychodystrophy: Some individuals may experience abnormalities in nail growth, such as thickening or splitting of the nails, associated with the condition.
It is important to note that symptoms can appear at any age but typically manifest in childhood or early adolescence. The severity and progression of the condition can vary, with some individuals experiencing mild symptoms and others facing significant skin challenges.
DSG1 Gene Keratosis Palmoplantaris Striata Type 1 Genetic Test
DNA Labs UAE offers a specialized genetic test to identify mutations in the DSG1 gene associated with Keratosis palmoplantaris striata type 1. This test is crucial for individuals with a family history of the condition or those exhibiting symptoms, as it can provide definitive diagnosis and guide management strategies. The test involves a simple blood draw or cheek swab, making it non-invasive and accessible.
The cost of the DSG1 gene test at DNA Labs UAE is 4400 AED. While the price may seem significant, the value of obtaining a clear diagnosis cannot be overstated. Early detection and diagnosis can lead to better management of symptoms, guidance on lifestyle adjustments, and informed decisions about family planning.
For more information about the DSG1 gene test and to schedule an appointment, please visit DNA Labs UAE.
In conclusion, Keratosis palmoplantaris striata type 1 is a genetic condition that can significantly impact an individual’s quality of life. Recognizing the symptoms early and undergoing genetic testing can provide valuable insights for managing the condition effectively. DNA Labs UAE is committed to providing accurate and comprehensive genetic testing services, including the DSG1 gene test, to help individuals and families navigate the challenges of genetic skin disorders.
