HLA-B*5701 Genotyping for Abacavir Hypersensitivity Test
At DNA Labs UAE, we offer the HLA-B*5701 Genotyping test for Abacavir Hypersensitivity. This test is used to determine an individual’s HLA-B*5701 genotype and assess their risk of developing hypersensitivity reactions to the antiretroviral drug Abacavir.
Test Details
The HLA-B*5701 genotyping test is specifically performed to identify individuals who have a significantly increased risk of developing severe hypersensitivity reactions to Abacavir. Abacavir is commonly used in the treatment of HIV infection, but approximately 5-8% of individuals with European ancestry and a smaller percentage of individuals from other populations carry the HLA-B*5701 allele.
Hypersensitivity reactions to Abacavir can manifest as a variety of symptoms, including fever, rash, gastrointestinal symptoms, respiratory symptoms, and in severe cases, life-threatening reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis.
It is important to note that HLA-B*5701 genotyping is specific to the risk of hypersensitivity reactions to Abacavir and does not provide information about other drug allergies or adverse reactions. Additionally, this test is only relevant for individuals who may be prescribed Abacavir as part of their HIV treatment.
Test Components
- EDTA Vacutainer (2ml)
Test Price
The cost of the HLA-B*5701 Genotyping for Abacavir Hypersensitivity Test is 600.0 AED.
Sample Condition
The test requires a peripheral blood sample.
Report Delivery
Reports are typically delivered within 1 week.
Method
The HLA-B*5701 genotyping test is performed using Sanger Sequencing.
Test Type
This test falls under the category of Genetics.
Referring Doctor
This test can be ordered by a Gynecologist.
Test Department
This test is conducted in the Genetics department.
Pre Test Information
HLA-B*57:01 Genotyping (for Abacavir Hypersensitivity) can be done with a doctor’s prescription. However, please note that the prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Test Name | HLA-B*5701 Genotyping for Abacavir Hypersensitivity Test |
---|---|
Components | EDTA Vacutainer (2ml) |
Price | 600.0 AED |
Sample Condition | Peripheral blood |
Report Delivery | 1 week |
Method | Sanger Sequencing |
Test type | Genetics |
Doctor | Gynecologist |
Test Department: | |
Pre Test Information | HLA-B*57:01 Genotyping (for Abacavir Hypersensitivity) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
Test Details |
HLA-B*57:01 genotyping is a genetic test used to determine an individual’s HLA-B*57:01 genotype. This test is specifically performed to assess the risk of developing hypersensitivity reactions to the antiretroviral drug Abacavir. Abacavir is commonly used in the treatment of HIV infection. However, approximately 5-8% of individuals with European ancestry and a smaller percentage of individuals from other populations carry the HLA-B*57:01 allele. These individuals have a significantly increased risk of developing a severe hypersensitivity reaction to Abacavir. The hypersensitivity reaction can manifest as a variety of symptoms, including fever, rash, gastrointestinal symptoms, respiratory symptoms, and in severe cases, life-threatening reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis. HLA-B*57:01 genotyping is typically performed prior to initiating Abacavir therapy to identify individuals at risk for hypersensitivity reactions. If an individual tests positive for HLA-B*57:01, Abacavir should be avoided, and alternative antiretroviral medications should be considered. Genotyping for HLA-B*57:01 can be done using various methods, including polymerase chain reaction (PCR) and sequence-specific oligonucleotide probes (SSOP). These techniques detect specific genetic variations associated with the HLA-B*57:01 allele. It is important to note that HLA-B*57:01 genotyping is specific to the risk of hypersensitivity reactions to Abacavir and does not provide information about other drug allergies or adverse reactions. Additionally, this test is only relevant for individuals who may be prescribed Abacavir as part of their HIV treatment. |