HLA-B*1502 Genotyping Carbamazepine Test
Cost: AED 1050.0
Symptoms and Diagnosis
HLA-B*1502 genotyping is a genetic test that determines the presence or absence of the HLA-B*1502 allele in an individual’s DNA. This test is specifically used to identify the HLA-B*1502 allele in individuals who are prescribed the antiepileptic drug carbamazepine. Carbamazepine is commonly used to treat epilepsy and certain types of nerve pain.
However, individuals who carry the HLA-B*1502 allele have an increased risk of developing a severe and potentially life-threatening skin reaction called Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) when taking carbamazepine.
Therefore, before starting carbamazepine treatment, it is recommended to perform an HLA-B*1502 genotyping test to identify individuals at risk of developing SJS/TEN. If the test result is positive for HLA-B*1502, alternative medications can be considered to avoid the risk of these severe skin reactions.
It is important to note that HLA-B*1502 genotyping is not routinely performed for all individuals prescribed carbamazepine but is typically recommended for individuals of Asian descent, as they have a higher prevalence of the HLA-B*1502 allele. Additionally, the test may also be recommended for individuals with a family history of SJS/TEN or a personal history of severe skin reactions to other drugs.
Test Details
The HLA-B*1502 genotyping test is typically performed using a blood sample or cheek swab. The sample is then sent to a laboratory where DNA analysis is conducted to determine the presence or absence of the HLA-B*1502 allele.
Test Name: HLA-B*1502 Genotyping Carbamazepine Test
Components: EDTA Vacutainer (2ml)
Price: AED 1050.0
Sample Condition: Peripheral blood
Report Delivery: 10 days
Method: Sanger Sequencing
Test Type: Genetics
Doctor: Gynecologist
Test Department: Pre Test Information
HLA-B*1502 Genotyping (Carbamazepine) can be done with a Doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Consult a Healthcare Professional
It is important to consult with a healthcare professional or a genetic counselor to understand the implications of HLA-B*1502 genotyping and the potential risks associated with carbamazepine treatment. They can help interpret the test results and provide appropriate guidance regarding medication choices and potential alternatives.
Test Name | HLA-B*1502 Genotyping Carbamazepine Test |
---|---|
Components | EDTA Vacutainer (2ml) |
Price | 1050.0 AED |
Sample Condition | Peripheral blood |
Report Delivery | 10 days |
Method | Sanger Sequencing |
Test type | Genetics |
Doctor | Gynecologist |
Test Department: | |
Pre Test Information | HLA-B*1502 Genotyping (Carbamazepine) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
Test Details | HLA-B*1502 genotyping is a genetic test that determines the presence or absence of the HLA-B*1502 allele in an individual’s DNA. This test is specifically used to identify the HLA-B*1502 allele in individuals who are prescribed the antiepileptic drug carbamazepine. Carbamazepine is commonly used to treat epilepsy and certain types of nerve pain. However, individuals who carry the HLA-B*1502 allele have an increased risk of developing a severe and potentially life-threatening skin reaction called Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) when taking carbamazepine. Therefore, before starting carbamazepine treatment, it is recommended to perform an HLA-B*1502 genotyping test to identify individuals at risk of developing SJS/TEN. If the test result is positive for HLA-B*1502, alternative medications can be considered to avoid the risk of these severe skin reactions. It is important to note that HLA-B*1502 genotyping is not routinely performed for all individuals prescribed carbamazepine but is typically recommended for individuals of Asian descent, as they have a higher prevalence of the HLA-B*1502 allele. Additionally, the test may also be recommended for individuals with a family history of SJS/TEN or a personal history of severe skin reactions to other drugs. The HLA-B*1502 genotyping test is typically performed using a blood sample or cheek swab. The sample is then sent to a laboratory where DNA analysis is conducted to determine the presence or absence of the HLA-B*1502 allele. It is important to consult with a healthcare professional or a genetic counselor to understand the implications of HLA-B*1502 genotyping and the potential risks associated with carbamazepine treatment. They can help interpret the test results and provide appropriate guidance regarding medication choices and potential alternatives. |