NPM1 Mutation Analysis Exon 12 Insertion Test
Test Name: NPM1 Mutation Analysis Exon 12 Insertion Test
Components: EDTA Vacutainer (2ml)
Price: 1200.0 AED
Sample Condition: Bone Marrow/Peripheral Blood
Report Delivery: 7-8 days
Method: Sanger Sequencing
Test Type: Genetics
Doctor: Gynecologist
Test Department:
Pre Test Information: NPM1 Mutation Analysis (Exon 12 insertion) can be done with a Doctor’s prescription. Prescription is not applicable for surgery and pregnancy cases or people planning to travel abroad.
Test Details
NPM1 mutation analysis refers to the testing and analysis of mutations in the NPM1 gene. The NPM1 gene is responsible for producing the nucleophosmin protein, which is involved in various cellular processes, including cell growth and division. One specific type of NPM1 mutation is the exon 12 insertion mutation. This mutation involves the insertion of a small piece of DNA sequence into exon 12 of the NPM1 gene.
This mutation is commonly found in patients with acute myeloid leukemia (AML) and is associated with a favorable prognosis. To perform NPM1 mutation analysis, a sample of the patient’s blood or bone marrow is collected. The DNA is then extracted from the sample and specific regions of the NPM1 gene, including exon 12, are amplified using a technique called polymerase chain reaction (PCR). The amplified DNA is then sequenced to identify any mutations, including the exon 12 insertion mutation.
The results of NPM1 mutation analysis can help in the diagnosis and prognosis of AML. Patients with the exon 12 insertion mutation have been shown to have a better response to certain chemotherapy treatments and a higher chance of achieving complete remission. In summary, NPM1 mutation analysis, specifically for the exon 12 insertion mutation, is a diagnostic and prognostic tool used in the management of AML.
Test Name | NPM1 Mutation Analysis Exon 12 insertion Test |
---|---|
Components | EDTA Vacutainer (2ml) |
Price | 1200.0 AED |
Sample Condition | Bone Marrow\/Peripheral Blood |
Report Delivery | 7-8 days |
Method | Sanger Sequencing |
Test type | Genetics |
Doctor | Gynecologist |
Test Department: | |
Pre Test Information | NPM1 Mutation Analysis (Exon 12 insertion) can be done with a Doctors prescription. Prescription is not applicable for surgery and pregnancy cases or people planing to travel abroad. |
Test Details |
NPM1 mutation analysis refers to the testing and analysis of mutations in the NPM1 gene. The NPM1 gene is responsible for producing the nucleophosmin protein, which is involved in various cellular processes, including cell growth and division. One specific type of NPM1 mutation is the exon 12 insertion mutation. This mutation involves the insertion of a small piece of DNA sequence into exon 12 of the NPM1 gene. This mutation is commonly found in patients with acute myeloid leukemia (AML) and is associated with a favorable prognosis. To perform NPM1 mutation analysis, a sample of the patient’s blood or bone marrow is collected. The DNA is then extracted from the sample and specific regions of the NPM1 gene, including exon 12, are amplified using a technique called polymerase chain reaction (PCR). The amplified DNA is then sequenced to identify any mutations, including the exon 12 insertion mutation. The results of NPM1 mutation analysis can help in the diagnosis and prognosis of AML. Patients with the exon 12 insertion mutation have been shown to have a better response to certain chemotherapy treatments and a higher chance of achieving complete remission. In summary, NPM1 mutation analysis, specifically for the exon 12 insertion mutation, is a diagnostic and prognostic tool used in the management of AML. |